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anti-TRPA1 antibody :: Rabbit TRPA1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS222811
Testing Data #1
Unit / Price
0.05 mg  /  $685 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TRPA1, Polyclonal Antibody

 Also Known As   

RABBIT ANTI HUMAN TRPA1

 Product Gene Name   

anti-TRPA1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604775
 3D Structure    ModBase 3D Structure for O75762
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
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 Specificity    This item detects Transient receptor potential A1 (TRPA1), an excitatory cation channel that is highly expressed in nociceptive neurons and plays an important role in inflammatory pain. TRPA1 mediates the response to the proalgesic bradykinin as well as to pungent irritants found in mustards, garlic, and cinnamon.

TRPA1 may also be involved in hearing (as the mammalian hair cell mechanotransducer) and in the detection of cold stimuli.
 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0mg/ml (lot specific)
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 Perservative Stabilisers    0.1% Sodium Azide (NaN3)
 Immunogen    Synthetic peptide: internal domain of human TRPA1, conjugated to Keyhole Limpet Hemocyanin (KLH).
Histology Positive Control Tissue
 Antiserum Preparation    Antisera to human TRPA1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-TRPA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TRPA1 antibody

   MBS222811 detects Transient receptor potential A1 (TRPA1), an excitatory cation channel that is highly expressed in nociceptive neurons and plays an important role in inflammatory pain. TRPA1 mediates the response to the proalgesic bradykinin as well as to pungent irritants found in mustards, garlic, and cinnamon. TRPA1 may also be involved in hearing (as the mammalian hair cell mechanotransducer) and in the detection of cold stimuli.
 Applications Tested/Suitable for anti-TRPA1 antibody   

Immunohistology Paraffin*

 Application Notes for anti-TRPA1 antibody    Immunohistology - Paraffin: Minimum Dilution: 10; Maximum Dilution: 20ug/ml; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
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 Testing Data #1 of anti-TRPA1 antibody    Staining of human spinal cord doesal root gangion with Rabbit anti Human TRPA1 (MBS222811)
anti-TRPA1 antibody Testing Data #1 image
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NCBI/Uniprot data below describe general gene information for TRPA1. It may not necessarily be applicable to this product.
 NCBI GI #    116534990
 NCBI GeneID    8989
 NCBI Accession #    NP_015628.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_007332.2 [Other Products]
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 UniProt Primary Accession #    O75762 [Other Products]
 UniProt Secondary Accession #    A6NIN6 [Other Products]
 UniProt Related Accession #    O75762 [Other Products]
 Molecular Weight    127,501 Da
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 NCBI Official Full Name    transient receptor potential cation channel subfamily A member 1
 NCBI Official Synonym Full Names    transient receptor potential cation channel, subfamily A, member 1
 NCBI Official Symbol    TRPA1 [Similar Products]
 NCBI Official Synonym Symbols   
FEPS; ANKTM1
[Similar Products]
 NCBI Protein Information    transient receptor potential cation channel subfamily A member 1; ankyrin-like with transmembrane domains 1; transformation-sensitive protein p120
 UniProt Protein Name    Transient receptor potential cation channel subfamily A member 1
 UniProt Synonym Protein Names   
Ankyrin-like with transmembrane domains protein 1; Transformation-sensitive protein p120
 Protein Family    Transient receptor potential cation channel subfamily
 UniProt Gene Name    TRPA1 [Similar Products]
 UniProt Synonym Gene Names    ANKTM1 [Similar Products]
 UniProt Entry Name    TRPA1_HUMAN
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 NCBI Summary for TRPA1    The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TRPA1    TRPA1: Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system. Belongs to the transient receptor (TC 1.A.4) family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 8q13

Cellular Component: stereocilium bundle; integral to plasma membrane; plasma membrane

Molecular Function: channel activity; calcium channel activity

Biological Process: response to drug; detection of mechanical stimulus involved in sensory perception of pain; detection of chemical stimulus involved in sensory perception of pain; response to hydrogen peroxide; response to pain; ion transport; thermoception; response to cold; transmembrane transport

Disease: Episodic Pain Syndrome, Familial, 1
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 Research Articles on TRPA1    1. analysis of the molecular basis determining inhibition and activation of nociceptive receptor TRPA1 protein
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TRPA1 antibodyPathways associated with anti-TRPA1 antibody
 Reference Product  PubMed Publications
 TRPM8 antibody  >273 publications with TRPA1 and TRPM8
 NGF antibody  >19 publications with TRPA1 and NGF
 BDKRB2 antibody  >2 publications with TRPA1 and BDKRB2
 CYLD antibody  >1 publications with TRPA1 and CYLD
 Products by Pathway  Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Stimuli-sensing Channels Pathway antibodies  Stimuli-sensing Channels Pathway Diagram
 TRP Channels Pathway antibodies  TRP Channels Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
Diseases associated with anti-TRPA1 antibodyOrgans/Tissues associated with anti-TRPA1 antibody
 Disease Name  Pubmed Publications
 Pain Antibodies  >500 publications with TRPA1 and Pain
 Nervous System Diseases Antibodies  >297 publications with TRPA1 and Nervous System Diseases
 Inflammation Antibodies  >222 publications with TRPA1 and Inflammation
 Hyperalgesia Antibodies  >147 publications with TRPA1 and Hyperalgesia
 Hypersensitivity Antibodies  >137 publications with TRPA1 and Hypersensitivity
 Sensation Disorders Antibodies  >103 publications with TRPA1 and Sensation Disorders
 Disease Models, Animal Antibodies  >85 publications with TRPA1 and Disease Models, Animal
 Cough Antibodies  >45 publications with TRPA1 and Cough
 Asthma Antibodies  >39 publications with TRPA1 and Asthma
 Respiration Disorders Antibodies  >28 publications with TRPA1 and Respiration Disorders
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >122 publications with TRPA1 and Skin
 Muscle Antibodies  >69 publications with TRPA1 and Muscle
 Lung Antibodies  >57 publications with TRPA1 and Lung
 Intestine Antibodies  >43 publications with TRPA1 and Intestine
 Kidney Antibodies  >38 publications with TRPA1 and Kidney
 Mouth Antibodies  >29 publications with TRPA1 and Mouth
 Prostate Antibodies  >10 publications with TRPA1 and Prostate
 Connective Tissue Antibodies  >3 publications with TRPA1 and Connective Tissue
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