NP_015628.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
127,501 Da
NCBI Official Full Name
transient receptor potential cation channel subfamily A member 1
NCBI Official Synonym Full Names
transient receptor potential cation channel, subfamily A, member 1
NCBI Official Synonym Symbols
NCBI Protein Information
transient receptor potential cation channel subfamily A member 1; transformation-sensitive protein p120; ankyrin-like with transmembrane domains 1
UniProt Protein Name
Transient receptor potential cation channel subfamily A member 1
UniProt Synonym Protein Names
Ankyrin-like with transmembrane domains protein 1; Transformation-sensitive protein p120
UniProt Synonym Gene Names
UniProt Entry Name
TRPA1_HUMAN
NCBI Summary for TRPA1
The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]
UniProt Comments for TRPA1
TRPA1: Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system. Belongs to the transient receptor (TC 1.A.4) family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 8q13
Cellular Component: stereocilium bundle; integral to plasma membrane; plasma membrane
Molecular Function: channel activity; calcium channel activity
Biological Process: response to drug; detection of mechanical stimulus involved in sensory perception of pain; detection of chemical stimulus involved in sensory perception of pain; response to hydrogen peroxide; response to pain; ion transport; response to cold; thermoception; transmembrane transport
Disease: Episodic Pain Syndrome, Familial, 1
Research Articles on TRPA1
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Products associated with anti-TRPA1 antibody
Pathways associated with anti-TRPA1 antibody
Diseases associated with anti-TRPA1 antibody
Organs/Tissues associated with anti-TRPA1 antibody
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