NP_003298.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
95,699 Da
NCBI Official Full Name
transient receptor potential cation channel subfamily M member 2
NCBI Official Synonym Full Names
transient receptor potential cation channel subfamily M member 2
NCBI Official Synonym Symbols
KNP3; EREG1; TRPC7; LTRPC2; NUDT9H; NUDT9L1 [Similar Products]
NCBI Protein Information
transient receptor potential cation channel subfamily M member 2
UniProt Protein Name
Transient receptor potential cation channel subfamily M member 2
UniProt Synonym Protein Names
Estrogen-responsive element-associated gene 1 protein; Long transient receptor potential channel 2; LTrpC-2; LTrpC2; Transient receptor potential channel 7; TrpC7
UniProt Synonym Gene Names
UniProt Entry Name
TRPM2_HUMAN
NCBI Summary for TRPM2
The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]
UniProt Comments for TRPM2
TRPM2: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Hydrolase; Transporter; EC 3.6.1.13; Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: cell soma; integral to plasma membrane; intracellular; neuron projection; plasma membrane
Molecular Function: ADP-ribose diphosphatase activity; calcium channel activity; manganese ion transmembrane transporter activity; sodium channel activity
Biological Process: calcium ion transport; metabolic process; positive regulation of insulin secretion; response to hydroperoxide; transmembrane transport
Research Articles on TRPM2
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Products associated with anti-TRPM2 antibody
Pathways associated with anti-TRPM2 antibody
Diseases associated with anti-TRPM2 antibody
Organs/Tissues associated with anti-TRPM2 antibody
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