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anti-TRPM8 antibody :: Rabbit anti-Rat, Mouse TRPM8 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS5400178 anti-TRPM8 antibody
Unit / Price
0.1 mg FITC  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TRPM8, Polyclonal Antibody

 Also Known As   

TRPM8 Antibody FITC-Conjugated

 Product Synonym Names    Long transient receptor potential channel 6; LTrpC6; Short form of the TRPM8 cationic channel; Transient receptor potential cation channel subfamily M member 8; Transient receptor potential p8; TRPP8 antibody
 Product Gene Name   

anti-TRPM8 antibody

[Similar Products]
 Matching Pairs    Antibody: TRPM8 (MBS5400178)
Positive Control: TRPM8 (MBS543355)
 Antibody/Peptide Pairs    TRPM8 peptide (MBS544622) is used for blocking the activity of TRPM8 antibody (MBS5400178)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q8R455
 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Rat, Mouse
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 Form/Format    FITC-Conjugated
 Concentration    0.6 ug/ul in antibody stabilization buffer (lot specific)
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 Immunogen    Synthetic peptide corresponding to unique amino acid sequence on TRPM8 protein.
 Expression    Expressed in dorsal root and trigeminal ganglia. Specifically expressed in a subset of sensory neurons, including cold-sensitive neurons in trigeminal neurons.
 Molecular Function    Calcium channel activity
 Subcellular Location    cell membrane, multi-pass membrane protein, membrane raft. (Note: Localizes to membrane rafts but is also loated in the cell membrane outside of these regions where channel response to cold is enhanced compared to membrane rafts)
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 Preparation and Storage    -20 degree C for long term storage
 Other Notes    Small volumes of anti-TRPM8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TRPM8 antibody

   FITC-Conjugated Transient receptor potential cation channel subfamily M member 8 Antibody
Involved in detection of sensations such as coolness, activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH
 Applications Tested/Suitable for anti-TRPM8 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-TRPM8 antibody    Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:500
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NCBI/Uniprot data below describe general gene information for TRPM8. It may not necessarily be applicable to this product.
 NCBI GI #    52851375
 NCBI GeneID    171384
 NCBI Accession #    NP_599198.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_134371.2 [Other Products]
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 UniProt Primary Accession #    Q8R455 [Other Products]
 UniProt Related Accession #    Q8R455 [Other Products]
 Molecular Weight    127,629 Da
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 NCBI Official Full Name    transient receptor potential cation channel subfamily M member 8
 NCBI Official Synonym Full Names    transient receptor potential cation channel, subfamily M, member 8
 NCBI Official Symbol    Trpm8 [Similar Products]
 NCBI Official Synonym Symbols   
CMR1
[Similar Products]
 NCBI Protein Information    transient receptor potential cation channel subfamily M member 8
 UniProt Protein Name    Transient receptor potential cation channel subfamily M member 8
 UniProt Synonym Protein Names   
Cold menthol receptor 1
 Protein Family    TRPM8 channel-associated factor
 UniProt Gene Name    Trpm8 [Similar Products]
 UniProt Synonym Gene Names    Cmr1 [Similar Products]
 UniProt Entry Name    TRPM8_RAT
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 NCBI Summary for TRPM8    excitatory ion channel; may be involved in transducing cold stimuli [RGD, Feb 2006]
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 UniProt Comments for TRPM8    TRPM8: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Channel, cation; Membrane protein, multi-pass

Cellular Component: external side of plasma membrane; integral to membrane; lipid raft; membrane

Molecular Function: calcium channel activity; ion channel activity; protein homodimerization activity

Biological Process: calcium ion transport; cellular calcium ion homeostasis; detection of temperature stimulus; protein homotetramerization; response to cold; response to temperature stimulus; thermoception
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 Research Articles on TRPM8    1. Retrograde tracing method indicated that TRPM8-IR nerve fibers in the gingiva and incisive papilla originate from small sensory neurons in the trigeminal ganglion.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-TRPM8 antibodyDiseases associated with anti-TRPM8 antibody
 Products by Pathway  Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Stimuli-sensing Channels Pathway antibodies  Stimuli-sensing Channels Pathway Diagram
 TRP Channels Pathway antibodies  TRP Channels Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Disease Name  Pubmed Publications
 Pain Antibodies  >259 publications with TRPM8 and Pain
 Hyperalgesia Antibodies  >62 publications with TRPM8 and Hyperalgesia
 Inflammation Antibodies  >60 publications with TRPM8 and Inflammation
 Disease Models, Animal Antibodies  >38 publications with TRPM8 and Disease Models, Animal
 Migraine Disorders Antibodies  >15 publications with TRPM8 and Migraine Disorders
 Migraine without Aura Antibodies  >12 publications with TRPM8 and Migraine without Aura
 Necrosis Antibodies  >11 publications with TRPM8 and Necrosis
 Hyperplasia Antibodies  >9 publications with TRPM8 and Hyperplasia
 Neoplasms, Experimental Antibodies  >8 publications with TRPM8 and Neoplasms, Experimental
 Hypertension Antibodies  >6 publications with TRPM8 and Hypertension
Organs/Tissues associated with anti-TRPM8 antibody
 Organ/Tissue Name  Pubmed Publications
 Dorsal Root Ganglion Antibodies  >121 publications with TRPM8 and Dorsal Root Ganglion
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