NP_076985.4
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
transient receptor potential cation channel subfamily M member 8
NCBI Official Synonym Full Names
transient receptor potential cation channel, subfamily M, member 8
NCBI Protein Information
transient receptor potential cation channel subfamily M member 8; trp-p8; LTrpC-6; OTTHUMP00000065206; transient receptor potential p8; short form of the TRPM8 cationic channel; long transient receptor potential channel 6; transient receptor potential subfamily M member 8
UniProt Protein Name
Transient receptor potential cation channel, subfamily M, member 8, isoform CRA_b
UniProt Entry Name
Q3YFM7_HUMAN
UniProt Comments for TRPM8
TRPM8: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Channel, cation; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: endoplasmic reticulum membrane; integral to membrane; plasma membrane; lipid raft; external side of plasma membrane
Molecular Function: protein binding; protein homodimerization activity; calcium channel activity
Biological Process: cellular calcium ion homeostasis; detection of temperature stimulus; thermoception; response to cold; transmembrane transport; protein homotetramerization
Research Articles on TRPM8
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Diseases associated with anti-TRPM8 antibody
Organs/Tissues associated with anti-TRPM8 antibody
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