NP_057197.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
85,981 Da
NCBI Official Full Name
transient receptor potential cation channel subfamily V member 2
NCBI Official Synonym Full Names
transient receptor potential cation channel, subfamily V, member 2
NCBI Protein Information
transient receptor potential cation channel subfamily V member 2; OTRPC2; osm-9-like TRP channel 2; vanilloid receptor-like protein 1
UniProt Protein Name
Transient receptor potential cation channel subfamily V member 2
UniProt Synonym Protein Names
Osm-9-like TRP channel 2; OTRPC2; Vanilloid receptor-like protein 1; VRL-1
UniProt Synonym Gene Names
UniProt Entry Name
TRPV2_HUMAN
NCBI Summary for Trpv2
This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008]
UniProt Comments for Trpv2
TRPV2: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, cation
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: cell surface; integral to plasma membrane; melanosome; plasma membrane; endomembrane system
Molecular Function: calcium channel activity; ion transmembrane transporter activity; ion channel activity; cation channel activity
Biological Process: response to temperature stimulus; response to heat; transport; sensory perception; positive regulation of axon extension; transmembrane transport
Research Articles on Trpv2
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Products associated with anti-Trpv2 antibody
Pathways associated with anti-Trpv2 antibody
Diseases associated with anti-Trpv2 antibody
Organs/Tissues associated with anti-Trpv2 antibody
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