NP_659505.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 91kDa Molecular Weight: 790
NCBI Official Full Name
transient receptor potential cation channel subfamily V member 3 isoform 2
NCBI Official Synonym Full Names
transient receptor potential cation channel subfamily V member 3
NCBI Protein Information
transient receptor potential cation channel subfamily V member 3
UniProt Protein Name
Transient receptor potential cation channel subfamily V member 3
UniProt Synonym Protein Names
Vanilloid receptor-like 3; VRL-3
UniProt Synonym Gene Names
UniProt Entry Name
TRPV3_HUMAN
NCBI Summary for TRPV3
This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
UniProt Comments for TRPV3
TRPV3: Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). May form a heteromeric channel with TRPV1. Interacts with TRPV1. Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion. Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV3 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Channel, cation; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17p13.2
Cellular Component: integral to membrane; plasma membrane; receptor complex
Molecular Function: calcium channel activity
Biological Process: negative regulation of hair cycle; response to heat; transmembrane transport
Disease: Palmoplantar Keratoderma, Mutilating, With Periorificial Keratotic Plaques; Palmoplantar Keratoderma, Nonepidermolytic, Focal 2
Research Articles on TRPV3
Precautions
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Pathways associated with anti-TRPV3 antibody
Diseases associated with anti-TRPV3 antibody
Organs/Tissues associated with anti-TRPV3 antibody
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