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anti-TSC1 antibody :: Rabbit anti-Human TSC1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7050923
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TSC1, Polyclonal Antibody

★Popular Item★
 Also Known As   

TSC1 Antibody

 Product Synonym Names    Hamartin; Tuberous sclerosis 1 protein; TSC1; KIAA0243; TSC
 Product Gene Name   

anti-TSC1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF013168 mRNA
 3D Structure    ModBase 3D Structure for Q92574
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Hamartin protein (101-344AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, PH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-12080 / sc-12082 / sc-12079 / sc-13013
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TSC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TSC1 antibody

   In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.
 Applications Tested/Suitable for anti-TSC1 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-TSC1 antibody    IHC: 1: 20-1: 200
IF: 1: 50-1: 200
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 Immunohistochemistry (IHC) of anti-TSC1 antibody    Immunohistochemistry of paraffin-embedded human placental tissue using MBS7050923 at dilution of 1:100
anti-TSC1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-TSC1 antibody    Immunofluorescent analysis of Hela cells using MBS7050923 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-TSC1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for TSC1. It may not necessarily be applicable to this product.
 NCBI GI #    4507693
 NCBI GeneID    7248
 NCBI Accession #    NP_000359.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000368.4 [Other Products]
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 UniProt Primary Accession #    Q92574 [Other Products]
 UniProt Secondary Accession #    Q5VVN5; B7Z897 [Other Products]
 UniProt Related Accession #    Q92574 [Other Products]
 Molecular Weight    124,015 Da
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 NCBI Official Full Name    hamartin isoform 1
 NCBI Official Synonym Full Names    tuberous sclerosis 1
 NCBI Official Symbol    TSC1 [Similar Products]
 NCBI Official Synonym Symbols   
LAM; TSC
[Similar Products]
 NCBI Protein Information    hamartin
 UniProt Protein Name    Hamartin
 UniProt Synonym Protein Names   
Tuberous sclerosis 1 protein
 Protein Family    Tuberous sclerosis 1 protein
 UniProt Gene Name    TSC1 [Similar Products]
 UniProt Synonym Gene Names    KIAA0243; TSC [Similar Products]
 UniProt Entry Name    TSC1_HUMAN
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 NCBI Summary for TSC1    This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
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 UniProt Comments for TSC1    TSC1: tuberous sclerosis protein 1 (TSC1). May have tumor suppressor activity. Together with tuberin (TSC2), inhibits mammalian target of rapamycin (mTOR)-mediated signaling to eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase. Regulated by the phosphatidylinositol 3-kinase/Akt pathway and phosphorylation of tuberin. Phosphorylated by cyclin-dependent kinase 1/cyclin B during the cell cycle.

Protein type: Motility/polarity/chemotaxis; Tumor suppressor

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: actin filament; cell cortex; cytoplasm; cytosol; lamellipodium; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; TSC1-TSC2 complex

Molecular Function: chaperone binding; GTPase regulator activity; protein binding; protein N-terminus binding

Biological Process: adult locomotory behavior; cell cycle arrest; cell-matrix adhesion; negative regulation of cell proliferation; negative regulation of insulin receptor signaling pathway; negative regulation of macroautophagy; negative regulation of TOR signaling pathway; negative regulation of translation; positive regulation of focal adhesion formation; protein stabilization; regulation of cell cycle; regulation of cell-matrix adhesion; regulation of phosphoprotein phosphatase activity; regulation of stress fiber formation; regulation of translation; response to insulin stimulus; rRNA export from nucleus

Disease: Focal Cortical Dysplasia Of Taylor; Lymphangioleiomyomatosis; Tuberous Sclerosis 1
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 Research Articles on TSC1    1. Gene expression level of TSC1 is significantly higher in AD patients when compared to normal controls.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TSC1 antibodyPathways associated with anti-TSC1 antibody
 Reference Product  PubMed Publications
 TSC2 antibody  >1034 publications with TSC1 and TSC2
 MTOR antibody  >625 publications with TSC1 and MTOR
 RHEB antibody  >166 publications with TSC1 and RHEB
 AKT1 antibody  >37 publications with TSC1 and AKT1
 RICTOR antibody  >26 publications with TSC1 and RICTOR
 IKBKB antibody  >9 publications with TSC1 and IKBKB
 RPS6KA1 antibody  >8 publications with TSC1 and RPS6KA1
 CDK1 antibody  >4 publications with TSC1 and CDK1
 AKT3 antibody  >3 publications with TSC1 and AKT3
 AKT2 antibody  >3 publications with TSC1 and AKT2
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 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
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 Angiopoietin Like Protein 8 Regulatory Pathway antibodies  Angiopoietin Like Protein 8 Regulatory Pathway Diagram
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 Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway antibodies  Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway Diagram
Diseases associated with anti-TSC1 antibodyOrgans/Tissues associated with anti-TSC1 antibody
 Disease Name  Pubmed Publications
 Tuberous Sclerosis Antibodies  >1184 publications with TSC1 and Tuberous Sclerosis
 Epilepsy Antibodies  >199 publications with TSC1 and Epilepsy
 Brain Diseases Antibodies  >165 publications with TSC1 and Brain Diseases
 Lymphangioleiomyomatosis Antibodies  >114 publications with TSC1 and Lymphangioleiomyomatosis
 Kidney Diseases Antibodies  >109 publications with TSC1 and Kidney Diseases
 Carcinoma, Renal Cell Antibodies  >53 publications with TSC1 and Carcinoma, Renal Cell
 Cardiovascular Diseases Antibodies  >48 publications with TSC1 and Cardiovascular Diseases
 Tuberous Sclerosis 1 Antibodies  >48 publications with TSC1 and Tuberous Sclerosis 1
 Liver Neoplasms Antibodies  >35 publications with TSC1 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >33 publications with TSC1 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >380 publications with TSC1 and Brain
 Kidney Antibodies  >192 publications with TSC1 and Kidney
 Lung Antibodies  >139 publications with TSC1 and Lung
 Blood Antibodies  >128 publications with TSC1 and Blood
 Skin Antibodies  >122 publications with TSC1 and Skin
 Muscle Antibodies  >115 publications with TSC1 and Muscle
 Heart Antibodies  >113 publications with TSC1 and Heart
 Liver Antibodies  >81 publications with TSC1 and Liver
 Vascular Antibodies  >57 publications with TSC1 and Vascular
 Bladder Antibodies  >39 publications with TSC1 and Bladder
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