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anti-TSG101 antibody :: Rabbit TSG101 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7605273 (SPECIAL PROMOTIONAL PRICING for a limited time)
Unit / Price
0.1 mg  /  $180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TSG101, Polyclonal Antibody

★Popular Item★
 Also Known As   

TSG101 Rabbit Polyclonal

 Product Synonym Names    ESCRT I complex subunit TSG101, TSG10, TSG101, tumor susceptibility gene 101, VPS23
 Product Gene Name   

anti-TSG101 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS7605273 Technical Datasheet    Technical Datasheet PDF
 OMIM    601387
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse ,Rat; other species are not tested.
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 Specificity    Please decide the specificity by homology
 Purity/Purification    >=95% as determined by SDS-PAGE
Immunogen Affinity Purified
 Form/Format    Liquid
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 Immunogen    Tumor susceptibility gene 101
 Buffer    PBS with 0.02% sodium azide and 50% glycerol pH 7.3
 Calculated MW    44 kDa
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 Preparation and Storage    Store at -20C for 24 months (Avoid repeated freeze / thaw cycles.)
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TSG101 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TSG101 antibody

   The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression .
 Applications Tested/Suitable for anti-TSG101 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-TSG101 antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:100
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 Immunohistochemistry of anti-TSG101 antibody    Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using MBS7605273 ( TSG101 Antibody)at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
anti-TSG101 antibody Immunohistochemistry (IHC) image
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 SDS PAGE of anti-TSG101 antibody    HeLa cells were subjected to SDS PAGE followed by western blot with MBS7605273 (TSG101 antibody) at dilution of 1:1000
anti-TSG101 antibody SDS PAGE  image
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NCBI/Uniprot data below describe general gene information for TSG101. It may not necessarily be applicable to this product.
 NCBI GI #    5454140
 NCBI GeneID    7251
 NCBI Accession #    NP_006283.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006292.3 [Other Products]
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 UniProt Secondary Accession #    Q9BUM5 [Other Products]
 UniProt Related Accession #    Q99816 [Other Products]
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 NCBI Official Full Name    tumor susceptibility gene 101 protein
 NCBI Official Synonym Full Names    tumor susceptibility 101
 NCBI Official Symbol    TSG101 [Similar Products]
 NCBI Official Synonym Symbols   
TSG10; VPS23
[Similar Products]
 NCBI Protein Information    tumor susceptibility gene 101 protein
 UniProt Protein Name    Tumor susceptibility gene 101 protein
 UniProt Synonym Protein Names   
ESCRT-I complex subunit TSG101
 Protein Family    Tumor susceptibility gene 101 protein
 UniProt Gene Name    TSG101 [Similar Products]
 UniProt Entry Name    TS101_HUMAN
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 NCBI Summary for TSG101    The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TSG101    TSG101: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Cell cycle regulation

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: cytoplasm; early endosome; endosome; endosome membrane; late endosome; late endosome membrane; multivesicular body; nucleolus; plasma membrane

Molecular Function: calcium-dependent protein binding; DNA binding; ligand-dependent nuclear receptor transcription coactivator activity; protein binding; protein homodimerization activity; transcription corepressor activity; ubiquitin binding; ubiquitin protein ligase binding; virion binding

Biological Process: autophagy; cell cycle arrest; cell division; endosome to lysosome transport; endosome transport; keratinocyte differentiation; negative regulation of cell proliferation; negative regulation of transcription, DNA-dependent; non-lytic virus budding; positive regulation of viral reproduction; protein monoubiquitination; protein transport; regulation of cell growth; regulation of MAP kinase activity; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; viral infectious cycle

Disease: Breast Cancer
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 Research Articles on TSG101    1. PSAP motif of OFR3 is required for hepatitis E virus exit and interaction with host TSG101.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TSG101 antibodyPathways associated with anti-TSG101 antibody
 Reference Product  PubMed Publications
 PDCD6IP antibody  >43 publications with TSG101 and PDCD6IP
 VPS28 antibody  >30 publications with TSG101 and VPS28
 CEP55 antibody  >12 publications with TSG101 and CEP55
 VPS37A antibody  >5 publications with TSG101 and VPS37A
 VPS37C antibody  >4 publications with TSG101 and VPS37C
 UBC antibody  >4 publications with TSG101 and UBC
 HGS antibody  >4 publications with TSG101 and HGS
 VPS37B antibody  >4 publications with TSG101 and VPS37B
 VPS36 antibody  >1 publications with TSG101 and VPS36
 Products by Pathway  Pathway Diagram
 Assembly Of The HIV Virion Pathway antibodies  Assembly Of The HIV Virion Pathway Diagram
 Budding And Maturation Of HIV Virion Pathway antibodies  Budding And Maturation Of HIV Virion Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 ESCRT-I Complex Pathway antibodies  ESCRT-I Complex Pathway Diagram
 ESCRT-I Complex Pathway antibodies  ESCRT-I Complex Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endosomal Sorting Complex Required For Transport (ESCRT) Pathway antibodies  Endosomal Sorting Complex Required For Transport (ESCRT) Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
Diseases associated with anti-TSG101 antibodyOrgans/Tissues associated with anti-TSG101 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >43 publications with TSG101 and Carcinoma
 Breast Neoplasms Antibodies  >40 publications with TSG101 and Breast Neoplasms
 Death Antibodies  >20 publications with TSG101 and Death
 Cell Transformation, Neoplastic Antibodies  >19 publications with TSG101 and Cell Transformation, Neoplastic
 Ovarian Neoplasms Antibodies  >14 publications with TSG101 and Ovarian Neoplasms
 Anemia Antibodies  >11 publications with TSG101 and Anemia
 Liver Diseases Antibodies  >9 publications with TSG101 and Liver Diseases
 Neoplasm Metastasis Antibodies  >9 publications with TSG101 and Neoplasm Metastasis
 Neurodegenerative Diseases Antibodies  >8 publications with TSG101 and Neurodegenerative Diseases
 Disease Models, Animal Antibodies  >7 publications with TSG101 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >40 publications with TSG101 and Blood
 Kidney Antibodies  >26 publications with TSG101 and Kidney
 Lung Antibodies  >18 publications with TSG101 and Lung
 Prostate Antibodies  >13 publications with TSG101 and Prostate
 Brain Antibodies  >11 publications with TSG101 and Brain
 Embryonic Tissue Antibodies  >8 publications with TSG101 and Embryonic Tissue
 Heart Antibodies  >7 publications with TSG101 and Heart
 Muscle Antibodies  >7 publications with TSG101 and Muscle
 Liver Antibodies  >6 publications with TSG101 and Liver
 Nerve Antibodies  >6 publications with TSG101 and Nerve
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