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anti-TSHZ1 antibody :: Rabbit TSHZ1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150495
Unit / Price
0.02 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TSHZ1, Polyclonal Antibody

 Also Known As   

TSHZ1 Antibody

 Product Synonym Names    TSHZ1; CAA; TSH1; NY-CO-33; SDCCAG33; Teashirt homolog 1; Antigen NY-CO-33; teashirt zinc finger homeobox 1
 Product Gene Name   

anti-TSHZ1 antibody

[Similar Products]
 Antibody/Peptide Pairs    TSHZ1 peptide (MBS151795) is used for blocking the activity of TSHZ1 antibody (MBS150495)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 614427
 3D Structure    ModBase 3D Structure for Q6ZSZ6
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    TSHZ1 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    TSHZ1 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human TSHZ1.
 Buffer    TSHZ1 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    TSHZ1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-TSHZ1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TSHZ1 antibody

   TSHZ1 Antibody: The Teashirt zinc finger homeobox (TSHZ) family comprise a family of evolutionarily conserved transcription factors that, in Drosophila, are active in specific body parts for patterning, but whose function in vertebrates is less clear. TSHZ1 has been found to be required for axial skeleton, soft palate and middle ear development in mice and may be involved in a common pathway with the Hox genes. Both TSHZ1 and the related protein TSHZ3 have been found to interact with FE65, an adapter protein that binds to the amyloid protein precursor (APP) in neurons. Together with SET, a component of the inhibitor of acetyl transferase, and histone deacetylases, these proteins formed a gene-silencing complex whose target includes caspase-4.
 Applications Tested/Suitable for anti-TSHZ1 antibody   

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

 Application Notes for anti-TSHZ1 antibody    TSHZ1 antibody can be used for detection of TSHZ1 by Western blot at 1 mug/mL. Antibody can also be used for immunocytochemistry starting at 2.5 mug/mL. For immunofluorescence start at 2.5 mug/mL.
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 Western Blot (WB) of anti-TSHZ1 antibody    Western blot analysis of TSHZ1 in A-20 cell lysate with TSHZ1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
anti-TSHZ1 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-TSHZ1 antibody    Immunofluorescence of TSHZ1 in A20 cells with TSHZ1 antibody at 20 μg/mL.
anti-TSHZ1 antibody Immunofluorescence (IF) image
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 Immunocytochemistry (ICC) of anti-TSHZ1 antibody    Immunocytochemistry of TSHZ1 in A20 cells with TSHZ1 antibody at 2.5 μg/mL.
anti-TSHZ1 antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for TSHZ1. It may not necessarily be applicable to this product.
 NCBI GI #    38201677
 NCBI GeneID    10194
 NCBI Accession #    NP_005777 [Other Products]
 NCBI GenBank Nucleotide #    NM_005786.5 [Other Products]
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 UniProt Primary Accession #    Q6ZSZ6 [Other Products]
 UniProt Secondary Accession #    O60534; Q4LE29; Q53EU4 [Other Products]
 UniProt Related Accession #    Q6ZSZ6 [Other Products]
 Molecular Weight    112,705 Da
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 NCBI Official Full Name    teashirt homolog 1
 NCBI Official Synonym Full Names    teashirt zinc finger homeobox 1
 NCBI Official Symbol    TSHZ1 [Similar Products]
 NCBI Official Synonym Symbols   
CAA; TSH1; NY-CO-33; SDCCAG33
[Similar Products]
 NCBI Protein Information    teashirt homolog 1; antigen NY-CO-33; serologically defined colon cancer antigen 33
 UniProt Protein Name    Teashirt homolog 1
 UniProt Synonym Protein Names   
Antigen NY-CO-33; Serologically defined colon cancer antigen 33
 Protein Family    Teashirt
 UniProt Gene Name    TSHZ1 [Similar Products]
 UniProt Synonym Gene Names    SDCCAG33; TSH1 [Similar Products]
 UniProt Entry Name    TSH1_HUMAN
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 NCBI Summary for TSHZ1    This gene encodes a colon cancer antigen that was defined by serological analysis of recombinant cDNA expression libraries. The encoded protein is a member of the teashirt C2H2-type zinc-finger protein family and may be involved in transcriptional regulation of developmental processes. Mutations in this gene may be associated with congenital aural atresia syndrome. [provided by RefSeq, Jan 2012]
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 UniProt Comments for TSHZ1    TSHZ1: Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Defects in TSHZ1 are the cause of congenital aural atresia (CAA). A rare anomaly of the ear that involves some degree of failure of the development of the external auditory canal. The malformation can also involve the tympanic membrane, ossicles and middle ear space. The inner ear development is most often normal. Different CAA forms are known. CAA type I is characterized by bony or fibrous atresia of the lateral part of the external auditory canal and an almost normal medial part and middle ear. CAA type II is the most frequent type and is characterized by partial or total aplasia of the external auditory canal. CAA type IIA involves an external auditory canal with either complete bony atresia of the medial part or partial aplasia that ends blindly in a fistula leading to a rudimentary tympanic membrane. CAA type IIB is characterized by bony stenosis of the total length of the external auditory canal. CAA type III involves bony atresia of the external auditory canal and a very small or absent middle-ear cavity. Belongs to the teashirt C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 18q22.3

Cellular Component: nucleus

Molecular Function: DNA binding; metal ion binding

Biological Process: anterior/posterior pattern formation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; middle ear morphogenesis; soft palate development

Disease: Aural Atresia, Congenital
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 Research Articles on TSHZ1    1. TSHZ1 is a key regulator of mammalian olfactory bulb development and function and controls the expression of PROKR2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TSHZ1 antibodyDiseases associated with anti-TSHZ1 antibody
 Reference Product  PubMed Publications
 ZADH2 antibody  >2 publications with TSHZ1 and ZADH2
 APBB1 antibody  >1 publications with TSHZ1 and APBB1
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >6 publications with TSHZ1 and Congenital Abnormalities
 Abnormalities, Multiple Antibodies  >4 publications with TSHZ1 and Abnormalities, Multiple
 Nervous System Diseases Antibodies  >1 publications with TSHZ1 and Nervous System Diseases
 Breast Neoplasms Antibodies  >1 publications with TSHZ1 and Breast Neoplasms
 Disease Models, Animal Antibodies  >1 publications with TSHZ1 and Disease Models, Animal
Organs/Tissues associated with anti-TSHZ1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with TSHZ1 and Brain
 Eye Antibodies  >3 publications with TSHZ1 and Eye
 Embryonic Tissue Antibodies  >3 publications with TSHZ1 and Embryonic Tissue
 Connective Tissue Antibodies  >1 publications with TSHZ1 and Connective Tissue
 Nerve Antibodies  >1 publications with TSHZ1 and Nerve
 Skin Antibodies  >1 publications with TSHZ1 and Skin
 Intestine Antibodies  >1 publications with TSHZ1 and Intestine
 Testis Antibodies  >1 publications with TSHZ1 and Testis
 Prostate Antibodies  >1 publications with TSHZ1 and Prostate
 Mouth Antibodies  >1 publications with TSHZ1 and Mouth
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