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anti-TSP1 antibody :: Rabbit anti-Human TSP1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS856286
Testing Data
Unit / Price
0.1 mg  /  $330 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TSP1, Polyclonal Antibody

 Also Known As   

TSP1 Antibody

 Product Gene Name   

anti-TSP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    188060
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Lyophilized TSP1 antibody purified by protein A column containing 0.02% NaN3
 Concentration    100ug/200ul (lot specific)
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 Source Note    Rabbit polyclonal TSP1 (1) antibody was raised against a partial length of 250aa recombinant human TSP1 protein (NM_003246).
 Reactivity Note    Not yet tested in other species.
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 Other Notes    Small volumes of anti-TSP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-TSP1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-TSP1 antibody   

Western Blot (WB)

 Application Notes for anti-TSP1 antibody    ELISA titer: 1:10,000-1:80,000
Western blot analysis: 1:200-1:1,000
Optimal dilutions/concentrations should be determined by the end user.
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 Testing Data of anti-TSP1 antibody    anti-TSP1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for TSP1. It may not necessarily be applicable to this product.
 NCBI GI #    40317625
 NCBI GeneID    7057
 NCBI Accession #    NP_003237.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003246 [Other Products]
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 UniProt Secondary Accession #    Q15667; Q59E99; A8K6H4; B4E3J7; B9EGH6 [Other Products]
 UniProt Related Accession #    P07996 [Other Products]
 Molecular Weight    120,148 Da
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 NCBI Official Full Name    Homo sapiens thrombospondin 1 (THBS1), mRNA
 NCBI Official Synonym Full Names    thrombospondin 1
 NCBI Official Symbol    THBS1 [Similar Products]
 NCBI Official Synonym Symbols   
TSP; THBS; TSP1; TSP-1; THBS-1
[Similar Products]
 NCBI Protein Information    thrombospondin-1; thrombospondin-1p180
 UniProt Protein Name    Thrombospondin-1
 UniProt Gene Name    THBS1 [Similar Products]
 UniProt Synonym Gene Names    TSP; TSP1 [Similar Products]
 UniProt Entry Name    TSP1_HUMAN
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 NCBI Summary for TSP1    The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TSP1    THBS1: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp. Ligand for CD36 mediating antiangiogenic properties. Belongs to the thrombospondin family.

Protein type: Inhibitor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 15q15

Cellular Component: extracellular matrix; extracellular space; cell surface; sarcoplasmic reticulum; endoplasmic reticulum; endoplasmic reticulum lumen; fibrinogen complex; extracellular region; secretory granule; external side of plasma membrane

Molecular Function: heparin binding; identical protein binding; laminin binding; calcium ion binding; integrin binding; protein binding; proteoglycan binding; fibroblast growth factor binding; phosphatidylserine binding; transforming growth factor beta binding; fibronectin binding; low-density lipoprotein binding; glycoprotein binding

Biological Process: extracellular matrix organization and biogenesis; activation of MAPK activity; response to magnesium ion; negative regulation of fibrinolysis; response to glucose stimulus; cell adhesion; cell cycle arrest; positive regulation of macrophage activation; response to drug; platelet activation; negative regulation of interleukin-12 production; positive regulation of chemotaxis; positive regulation of blood vessel endothelial cell migration; response to testosterone stimulus; negative regulation of cell-matrix adhesion; negative regulation of blood vessel endothelial cell migration; response to unfolded protein; positive regulation of angiogenesis; response to mechanical stimulus; negative regulation of endothelial cell proliferation; regulation of cGMP metabolic process; peptide cross-linking; response to calcium ion; response to progesterone stimulus; negative regulation of apoptosis; positive regulation of blood coagulation; positive regulation of translation; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; negative regulation of caspase activity; behavioral response to pain; platelet degranulation; positive regulation of tumor necrosis factor biosynthetic process; protein amino acid O-linked glycosylation; positive regulation of transforming growth factor-beta1 production; chronic inflammatory response; cell migration; negative regulation of focal adhesion formation; positive regulation of transforming growth factor beta receptor signaling pathway; engulfment of apoptotic cell; post-translational protein modification; positive regulation of protein kinase B signaling cascade; negative regulation of angiogenesis; cellular protein metabolic process; negative regulation of dendritic cell antigen processing and presentation; response to hypoxia; immune response; sprouting angiogenesis; blood coagulation; positive regulation of phosphorylation; positive regulation of cell migration
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Product References and Citations for anti-TSP1 antibody

   (1) Laklai,H., Laval,S., Dumartin,L., et al.Thrombospondin-1 is a critical effector of oncosuppressive activity of sst2 somatostatin receptor on pancreatic cancer. Proc. Natl. Acad. Sci. U.S.A. 106 (42), 17769-17774 (2009)
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 Research Articles on TSP1    1. TSP-1 inhibited angiogenesis potential of early and late endothelial progenitor cells in vitro. This inhibition may be regulated by TSP-1's interaction with CD47, resulting in down regulation of VEGFR2 phosphorylation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TSP1 antibodyPathways associated with anti-TSP1 antibody
 Reference Product  PubMed Publications
 CD36 antibody  >180 publications with TSP1 and CD36
 TGFB1 antibody  >165 publications with TSP1 and TGFB1
 CD47 antibody  >141 publications with TSP1 and CD47
 VEGFA antibody  >54 publications with TSP1 and VEGFA
 MMP9 antibody  >20 publications with TSP1 and MMP9
 PDGFB antibody  >15 publications with TSP1 and PDGFB
 FN1 antibody  >7 publications with TSP1 and FN1
 ITGB3 antibody  >4 publications with TSP1 and ITGB3
 ITGA6 antibody  >1 publications with TSP1 and ITGA6
 Products by Pathway  Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Inflammatory Response Pathway antibodies  Inflammatory Response Pathway Diagram
Diseases associated with anti-TSP1 antibodyOrgans/Tissues associated with anti-TSP1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >216 publications with TSP1 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >200 publications with TSP1 and Disease Models, Animal
 Inflammation Antibodies  >195 publications with TSP1 and Inflammation
 Fibrosis Antibodies  >140 publications with TSP1 and Fibrosis
 Neoplasms, Experimental Antibodies  >123 publications with TSP1 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >118 publications with TSP1 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >109 publications with TSP1 and Neoplasm Metastasis
 Necrosis Antibodies  >99 publications with TSP1 and Necrosis
 Kidney Diseases Antibodies  >91 publications with TSP1 and Kidney Diseases
 Heart Diseases Antibodies  >79 publications with TSP1 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >948 publications with TSP1 and Vascular
 Blood Antibodies  >901 publications with TSP1 and Blood
 Muscle Antibodies  >257 publications with TSP1 and Muscle
 Kidney Antibodies  >161 publications with TSP1 and Kidney
 Eye Antibodies  >153 publications with TSP1 and Eye
 Lung Antibodies  >150 publications with TSP1 and Lung
 Brain Antibodies  >142 publications with TSP1 and Brain
 Bone Antibodies  >131 publications with TSP1 and Bone
 Skin Antibodies  >118 publications with TSP1 and Skin
 Heart Antibodies  >118 publications with TSP1 and Heart
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