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anti-TSPAN12 antibody :: Rabbit TSPAN12 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9208479
Unit / Price
0.08 mL  /  $155 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TSPAN12, Polyclonal Antibody

 Also Known As   

TSPAN12 Antibody (C-term)

 Product Synonym Names    Tetraspanin-12; Tspan-12; Tetraspan NET-2; Transmembrane 4 superfamily member 12; TSPAN12; NET2; TM4SF12
 Product Gene Name   

anti-TSPAN12 antibody

[Similar Products]
 Antibody/Peptide Pairs    TSPAN12 peptide (MBS9227795) is used for blocking the activity of TSPAN12 antibody (MBS9208479)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    232-259
 OMIM    613138
 3D Structure    ModBase 3D Structure for O95859
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human (Predicted Reactivity: Bovine, Mouse, Rat)
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 Specificity    This TSPAN12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-259 amino acids from the C-terminal region of human TSPAN12.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    Vial Concentration: 0.5 (lot specific)
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 Antigen Type    Synthetic Peptide
 Antigen Source    HUMAN
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-TSPAN12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TSPAN12 antibody

   TSPAN12 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.
 Product Categories/Family for anti-TSPAN12 antibody    Cell Biology; Neuroscience
 Applications Tested/Suitable for anti-TSPAN12 antibody   

Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

 Application Notes for anti-TSPAN12 antibody    WB~~1:1000
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 Western Blot (WB) of anti-TSPAN12 antibody    Western blot analysis of TSPAN12 Antibody (C-term) in T47D cell line lysates (35ug/lane). TSPAN12 (arrow) was detected using the purified Pab.
anti-TSPAN12 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TSPAN12 antibody    Formalin-fixed and paraffin-embedded human brain tissue reacted with TSPAN12 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
anti-TSPAN12 antibody Immunohistochemistry (IHC) (IHC) image
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 Flow Cytometry (FC/FACS) of anti-TSPAN12 antibody    TSPAN12 Antibody (C-term) flow cytometric analysis of 293 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-TSPAN12 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for TSPAN12. It may not necessarily be applicable to this product.
 NCBI GI #    6912528
 NCBI GeneID    23554
 NCBI Accession #    NP_036470.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012338.3 [Other Products]
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 UniProt Primary Accession #    O95859 [Other Products]
 UniProt Secondary Accession #    Q549U9; Q8N5Y0; A4D0V8; B4DRG6 [Other Products]
 UniProt Related Accession #    O95859 [Other Products]
 Molecular Weight    35383
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 NCBI Official Full Name    tetraspanin-12
 NCBI Official Synonym Full Names    tetraspanin 12
 NCBI Official Symbol    TSPAN12 [Similar Products]
 NCBI Official Synonym Symbols   
EVR5; NET2; NET-2; TM4SF12
[Similar Products]
 NCBI Protein Information    tetraspanin-12
 UniProt Protein Name    Tetraspanin-12
 UniProt Synonym Protein Names   
Tetraspan NET-2; Transmembrane 4 superfamily member 12
 UniProt Gene Name    TSPAN12 [Similar Products]
 UniProt Synonym Gene Names    NET2; TM4SF12; Tspan-12 [Similar Products]
 UniProt Entry Name    TSN12_HUMAN
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 NCBI Summary for TSPAN12    The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TSPAN12    TSPAN12: a multi-pass membrane protein. Member of the transmembrane 4 superfamily, also known as the tetraspanin family. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity. Defects in TSPAN12 are the cause of vitreoretinopathy exudative type 5 (EVR5). It is a disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. Twp isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.

Chromosomal Location of Human Ortholog: 7q31.31

Cellular Component: membrane; integral to plasma membrane; integral to membrane

Molecular Function: Wnt receptor activity

Biological Process: cell surface receptor linked signal transduction; angiogenesis; regulation of angiogenesis

Disease: Exudative Vitreoretinopathy 5
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Product References and Citations for anti-TSPAN12 antibody

   Xu,D., et.al., FASEB J. 23 (11), 3674-3681 (2009)
Berditchevski,F.et.al., J. Cell. Sci. 114 (PT 23), 4143-4151 (2001)
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 Research Articles on TSPAN12    1. Novel mutations have been described in the TSPAN12 gene in Chinese patients with familial exudative vitreoretinopathy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TSPAN12 antibodyDiseases associated with anti-TSPAN12 antibody
 Reference Product  PubMed Publications
 LRP5 antibody  >22 publications with TSPAN12 and LRP5
 FZD4 antibody  >22 publications with TSPAN12 and FZD4
 NDP antibody  >21 publications with TSPAN12 and NDP
 ADAM10 antibody  >2 publications with TSPAN12 and ADAM10
 CADPS2 antibody  >1 publications with TSPAN12 and CADPS2
 Disease Name  Pubmed Publications
 Vascular Diseases Antibodies  >8 publications with TSPAN12 and Vascular Diseases
 Exudative Vitreoretinopathy 5 Antibodies  >7 publications with TSPAN12 and Exudative Vitreoretinopathy 5
 Cardiovascular Diseases Antibodies  >4 publications with TSPAN12 and Cardiovascular Diseases
 Disease Susceptibility Antibodies  >4 publications with TSPAN12 and Disease Susceptibility
 Inflammation Antibodies  >3 publications with TSPAN12 and Inflammation
 Breast Neoplasms Antibodies  >2 publications with TSPAN12 and Breast Neoplasms
 Nervous System Diseases Antibodies  >2 publications with TSPAN12 and Nervous System Diseases
 Liver Diseases Antibodies  >1 publications with TSPAN12 and Liver Diseases
 Fibrosis Antibodies  >1 publications with TSPAN12 and Fibrosis
 Ovarian Neoplasms Antibodies  >1 publications with TSPAN12 and Ovarian Neoplasms
Organs/Tissues associated with anti-TSPAN12 antibody
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >18 publications with TSPAN12 and Eye
 Vascular Antibodies  >11 publications with TSPAN12 and Vascular
 Brain Antibodies  >5 publications with TSPAN12 and Brain
 Bone Antibodies  >3 publications with TSPAN12 and Bone
 Muscle Antibodies  >2 publications with TSPAN12 and Muscle
 Heart Antibodies  >2 publications with TSPAN12 and Heart
 Lung Antibodies  >2 publications with TSPAN12 and Lung
 Ascites Antibodies  >1 publications with TSPAN12 and Ascites
 Liver Antibodies  >1 publications with TSPAN12 and Liver
 Adrenal Gland Antibodies  >1 publications with TSPAN12 and Adrenal Gland
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