NP_004464.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,076 Da
NCBI Official Full Name
forkhead box protein E1
NCBI Official Synonym Full Names
forkhead box E1
NCBI Official Synonym Symbols
TTF2; FOXE2; HFKH4; HFKL5; TITF2; TTF-2; FKHL15 [Similar Products]
NCBI Protein Information
forkhead box protein E1
UniProt Protein Name
Forkhead box protein E1
UniProt Synonym Protein Names
Forkhead box protein E2; Forkhead-related protein FKHL15; HFKH4; HNF-3/fork head-like protein 5; HFKL5; Thyroid transcription factor 2; TTF-2
UniProt Synonym Gene Names
UniProt Entry Name
FOXE1_HUMAN
NCBI Summary for TTF2
This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I. [provided by RefSeq, Jul 2008]
UniProt Comments for TTF2
FOXE1: Probable transcription factor. Could be involved in thyroid gland organogenesis. Defects in FOXE1 are the cause of Bamforth-Lazarus syndrome (BLS). BLS is associated with thyroid agenesis, cleft palate and choanal atresia.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 9q22
Cellular Component: nucleus
Molecular Function: DNA binding; sequence-specific DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; anatomical structure morphogenesis; cell migration; hair follicle morphogenesis; thymus development; positive regulation of transcription, DNA-dependent; thyroid hormone generation; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; embryonic organ morphogenesis; thyroid gland development; hard palate development; soft palate development; negative regulation of transcription, DNA-dependent
Disease: Hypothyroidism, Athyroidal, With Spiky Hair And Cleft Palate; Thyroid Cancer, Nonmedullary, 4
Research Articles on TTF2
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Products associated with anti-TTF2 antibody
Diseases associated with anti-TTF2 antibody
Organs/Tissues associated with anti-TTF2 antibody
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