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anti-TTR antibody :: Rabbit TTR / Transthyretin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS242127
Unit / Price
0.05 mL  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TTR / Transthyretin, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit Polyclonal (IgG) to Human TTR / Transthyretin

 Product Synonym Names    Anti-TTR / Transthyretin Antibody IHC-plus; TTR; ATTR; CTS1; CTS; HsT2651; PALB; Prealbumin; TBPA; Transthyretin; Carpal tunnel syndrome 1; Prealbumin; amyloidosis type I; Thyroxine-binding prealbumin; Human TTR; Transthyretin
 Product Gene Name   

anti-TTR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 176300
 3D Structure    ModBase 3D Structure for P02766
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Ammonium sulfate precipitation
 Form/Format    HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol
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 Target Species    Human
 Immunogen Description    Recombinant human TTR / Transthyretin purified from E Coli.
 Immunogen Type    Recombinant protein
 Immunogen    TTR / Transthyretin antibody was raised against recombinant human TTR / Transthyretin purified from E Coli.
 Usage    Immunohistochemistry: MBS242127 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for MBS242127 was determined to be 5 ug/ml.
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 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
 Other Notes    Small volumes of anti-TTR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TTR antibody

   TTR / Transthyretin is transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.
 Applications Tested/Suitable for anti-TTR antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-TTR antibody    IHC-P (5 ug/ml), IP, WB (1:2000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-TTR antibody    Anti-TTR / Transthyretin antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-TTR antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-TTR antibody     
anti-TTR antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TTR. It may not necessarily be applicable to this product.
 NCBI GI #    4507725
 NCBI GeneID    7276
 NCBI Accession #    NP_000362.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000371.3 [Other Products]
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 UniProt Primary Accession #    P02766 [Other Products]
 UniProt Secondary Accession #    Q549C7; Q6IB96; Q9UBZ6; Q9UCM9 [Other Products]
 UniProt Related Accession #    P02766 [Other Products]
 Molecular Weight    15,887 Da
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 NCBI Official Full Name    transthyretin
 NCBI Official Synonym Full Names    transthyretin
 NCBI Official Symbol    TTR [Similar Products]
 NCBI Official Synonym Symbols   
CTS; CTS1; PALB; TBPA; HEL111; HsT2651
[Similar Products]
 NCBI Protein Information    transthyretin; ATTR; carpal tunnel syndrome 1; thyroxine-binding prealbumin; epididymis luminal protein 111; prealbumin, amyloidosis type I
 UniProt Protein Name    Transthyretin
 UniProt Synonym Protein Names   
ATTR; Prealbumin; TBPA
 Protein Family    Transthyretin
 UniProt Gene Name    TTR [Similar Products]
 UniProt Synonym Gene Names    PALB [Similar Products]
 UniProt Entry Name    TTHY_HUMAN
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 NCBI Summary for TTR    This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009]
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 UniProt Comments for TTR    TTR: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR). A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor. Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE). It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities. Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1). It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis. Belongs to the transthyretin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 18q12.1

Cellular Component: extracellular space; protein complex; cytoplasm; extracellular region

Molecular Function: identical protein binding; protein binding; protein heterodimerization activity; hormone activity

Biological Process: phototransduction, visible light; extracellular matrix organization and biogenesis; transport; retinol metabolic process; retinoid metabolic process

Disease: Hyperthyroxinemia, Dystransthyretinemic; Carpal Tunnel Syndrome; Amyloidosis, Hereditary, Transthyretin-related
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 Research Articles on TTR    1. Data suggest that TTR and TTR mutants (seen in subjects with senile systemic amyloidosis) have similar amyloidogenic potential and similar thermodynamic/kinetic stabilities; this study emphasizes protein stability under physiological conditions.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TTR antibodyPathways associated with anti-TTR antibody
 Reference Product  PubMed Publications
 RBP4 antibody  >34 publications with TTR and RBP4
 SERPINA7 antibody  >30 publications with TTR and SERPINA7
 APP antibody  >11 publications with TTR and APP
 APOA1 antibody  >7 publications with TTR and APOA1
 APCS antibody  >2 publications with TTR and APCS
 FOXA3 antibody  >2 publications with TTR and FOXA3
 CST3 antibody  >1 publications with TTR and CST3
 Products by Pathway  Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Non-integrin Membrane-ECM Interactions Pathway antibodies  Non-integrin Membrane-ECM Interactions Pathway Diagram
 Retinoid Cycle Disease Events Pathway antibodies  Retinoid Cycle Disease Events Pathway Diagram
 Retinoid Metabolism And Transport Pathway antibodies  Retinoid Metabolism And Transport Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway antibodies  The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway Diagram
Diseases associated with anti-TTR antibodyOrgans/Tissues associated with anti-TTR antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >650 publications with TTR and Nervous System Diseases
 Amyloidosis, Familial Antibodies  >590 publications with TTR and Amyloidosis, Familial
 Amyloid Neuropathies, Familial Antibodies  >412 publications with TTR and Amyloid Neuropathies, Familial
 Cardiovascular Diseases Antibodies  >230 publications with TTR and Cardiovascular Diseases
 Heart Diseases Antibodies  >196 publications with TTR and Heart Diseases
 Brain Diseases Antibodies  >144 publications with TTR and Brain Diseases
 Liver Diseases Antibodies  >133 publications with TTR and Liver Diseases
 Liver Neoplasms Antibodies  >72 publications with TTR and Liver Neoplasms
 Inflammation Antibodies  >71 publications with TTR and Inflammation
 Carcinoma, Hepatocellular Antibodies  >70 publications with TTR and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >489 publications with TTR and Liver
 Heart Antibodies  >244 publications with TTR and Heart
 Brain Antibodies  >244 publications with TTR and Brain
 Muscle Antibodies  >124 publications with TTR and Muscle
 Kidney Antibodies  >118 publications with TTR and Kidney
 Eye Antibodies  >96 publications with TTR and Eye
 Lung Antibodies  >59 publications with TTR and Lung
 Skin Antibodies  >50 publications with TTR and Skin
 Embryonic Tissue Antibodies  >33 publications with TTR and Embryonic Tissue
 Pancreas Antibodies  >31 publications with TTR and Pancreas
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