NP_001257328.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,297 Da
NCBI Official Full Name
tubulin alpha-1A chain isoform 1
NCBI Official Synonym Full Names
tubulin, alpha 1a
NCBI Protein Information
tubulin alpha-1A chain
UniProt Protein Name
Tubulin alpha-1A chain
UniProt Synonym Protein Names
Alpha-tubulin 3; Tubulin B-alpha-1; Tubulin alpha-3 chain
UniProt Synonym Gene Names
UniProt Entry Name
TBA1A_HUMAN
NCBI Summary for TUBA1/3/4
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, mental retardation, and early-onset epilepsy and caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
UniProt Comments for TUBA1/3/4
TUBA1A: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. Expressed at a high level in fetal brain. Belongs to the tubulin family.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal
Chromosomal Location of Human Ortholog: 12q13.12
Cellular Component: microtubule; recycling endosome; cytoplasmic microtubule; cytosol; nucleus
Molecular Function: GTPase activity; protein domain specific binding; protein binding; GTP binding; structural constituent of cytoskeleton; structural molecule activity
Biological Process: protein polymerization; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; cell division; organelle organization and biogenesis; mitotic cell cycle; cytoskeleton-dependent intracellular transport; G2/M transition of mitotic cell cycle; microtubule-based process
Disease: Lissencephaly 3
Research Articles on TUBA1/3/4
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Products associated with anti-TUBA1/3/4 antibody
Pathways associated with anti-TUBA1/3/4 antibody
Diseases associated with anti-TUBA1/3/4 antibody
Organs/Tissues associated with anti-TUBA1/3/4 antibody
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