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anti-TUSC3 antibody :: Goat TUSC3/N33 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421607
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TUSC3/N33, Polyclonal Antibody

 Also Known As   

Goat anti-TUSC3/N33 Antibody

 Product Synonym Names    TUSC3; tumor suppressor candidate 3; D8S1992; MGC13453; N33; OST3A; Putative prostate cancer tumor suppressor; TUSC3 antibody; tumor suppressor candidate 3 antibody; D8S1992 antibody; MGC13453 antibody; N33 antibody; OST3A antibody; Putative prostate cancer tumor suppressor antibody; TUSC3 / N33
 Product Gene Name   

anti-TUSC3 antibody

[Similar Products]
 Product Synonym Gene Name    N33 [Similar Products]
 Antibody/Peptide Pairs    TUSC3 / N33 peptide (MBS425516) is used for blocking the activity of TUSC3/N33 antibody (MBS421607)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    PQRQCSVCRQ AN
 OMIM    601385
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence PQRQCSVCRQAN, from the internal region of the protein sequence according to NP_006756.2; NP_839952.1.
 Epitope    Internal region
 Note    This antibody is expected to recognise both reported isoforms (NP_006756.2; NP_839952.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-TUSC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TUSC3 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-TUSC3 antibody    Peptide ELISA: Antibody detection limit dilution 1: 1000.
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 Western Blot (WB) of anti-TUSC3 antibody    (1ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-TUSC3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TUSC3. It may not necessarily be applicable to this product.
 NCBI GI #    30410788
 NCBI GeneID    7991
 NCBI Accession #    NP_006756.2 [Other Products]
 NCBI Related Accession #    NP_839952.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006765.3 [Other Products]
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 UniProt Secondary Accession #    Q14911; Q14912; Q96FW0; A8MSM0; D3DSP2 [Other Products]
 UniProt Related Accession #    Q13454 [Other Products]
 Molecular Weight    39,558 Da
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 NCBI Official Full Name    tumor suppressor candidate 3 isoform a
 NCBI Official Synonym Full Names    tumor suppressor candidate 3
 NCBI Official Symbol    TUSC3 [Similar Products]
 NCBI Official Synonym Symbols   
M33; N33; MRT7; MRT22; OST3A; D8S1992
[Similar Products]
 NCBI Protein Information    tumor suppressor candidate 3
 UniProt Protein Name    Tumor suppressor candidate 3
 UniProt Synonym Protein Names   
Magnesium uptake/transporter TUSC3; Protein N33
 Protein Family    Tumor suppressor candidate
 UniProt Gene Name    TUSC3 [Similar Products]
 UniProt Synonym Gene Names    N33 [Similar Products]
 UniProt Entry Name    TUSC3_HUMAN
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 NCBI Summary for TUSC3    This gene is a candidate tumor suppressor gene. It is located within a homozygously deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TUSC3    TUSC3: Magnesium transporter. May be involved in N- glycosylation through its association with N-oligosaccharyl transferase. Defects in TUSC3 are the cause of mental retardation autosomal recessive type 7 (MRT7); also known as mental retardation non-syndromic autosomal recessive 7. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Belongs to the OST3/OST6 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane; mitochondrion; oligosaccharyl transferase complex; plasma membrane

Molecular Function: dolichyl-diphosphooligosaccharide-protein glycotransferase activity; magnesium ion transmembrane transporter activity

Biological Process: cognition; magnesium ion transport; protein amino acid N-linked glycosylation; protein amino acid N-linked glycosylation via asparagine; transmembrane transport

Disease: Mental Retardation, Autosomal Recessive 7
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 Research Articles on TUSC3    1. The TUSC3 gene is associated with mental retardation in the Qinba mountain area in China; the sixth exon of the TUSC3 gene may contribute to the risk of developing the disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-TUSC3 antibodyDiseases associated with anti-TUSC3 antibody
 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Miscellaneous Transport And Binding Events Pathway antibodies  Miscellaneous Transport And Binding Events Pathway Diagram
 N-Glycan Biosynthesis Pathway antibodies  N-Glycan Biosynthesis Pathway Diagram
 N-Glycan Biosynthesis Pathway antibodies  N-Glycan Biosynthesis Pathway Diagram
 N-glycosylation By Oligosaccharyltransferase Pathway antibodies  N-glycosylation By Oligosaccharyltransferase Pathway Diagram
 N-glycosylation By Oligosaccharyltransferase Pathway antibodies  N-glycosylation By Oligosaccharyltransferase Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >2 publications with TUSC3 and Liver Diseases
 Liver Neoplasms Antibodies  >2 publications with TUSC3 and Liver Neoplasms
 Immune System Diseases Antibodies  >1 publications with TUSC3 and Immune System Diseases
 Cardiovascular Diseases Antibodies  >1 publications with TUSC3 and Cardiovascular Diseases
 Neoplasm Metastasis Antibodies  >1 publications with TUSC3 and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >1 publications with TUSC3 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >1 publications with TUSC3 and Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >1 publications with TUSC3 and Carcinoma, Hepatocellular
 Necrosis Antibodies  >1 publications with TUSC3 and Necrosis
 Prostatic Neoplasms Antibodies  >1 publications with TUSC3 and Prostatic Neoplasms
Organs/Tissues associated with anti-TUSC3 antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with TUSC3 and Lung
 Testis Antibodies  >1 publications with TUSC3 and Testis
 Heart Antibodies  >1 publications with TUSC3 and Heart
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