NP_003319.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
61,258 Da
NCBI Official Full Name
tyrosine-protein kinase TXK
NCBI Official Synonym Full Names
TXK tyrosine kinase
NCBI Protein Information
tyrosine-protein kinase TXK
UniProt Protein Name
Tyrosine-protein kinase TXK
UniProt Synonym Protein Names
Protein-tyrosine kinase 4; Resting lymphocyte kinase
UniProt Synonym Gene Names
UniProt Entry Name
TXK_HUMAN
UniProt Comments for TXK
TXK: Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T- cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskekleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell- specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr- 201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor. Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
Protein type: Protein kinase, tyrosine (non-receptor); Protein kinase, TK; EC 2.7.10.2; Kinase, protein; TK group; Tec family
Chromosomal Location of Human Ortholog: 4p12
Cellular Component: cytoplasm; extrinsic to internal side of plasma membrane; nucleus
Molecular Function: ATP binding; non-membrane spanning protein tyrosine kinase activity; protein binding; receptor binding
Biological Process: adaptive immune response; cell differentiation; cytokine production; integrin-mediated signaling pathway; phospholipase C activation; positive regulation of interferon-gamma production; positive regulation of transcription from RNA polymerase II promoter; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; T cell receptor signaling pathway; tissue regeneration; transcription from RNA polymerase II promoter; transmembrane receptor protein tyrosine kinase signaling pathway
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Pathways associated with anti-TXK antibody
Diseases associated with anti-TXK antibody
Organs/Tissues associated with anti-TXK antibody
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