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anti-TXK antibody :: Rabbit anti-Human, Rat TXK Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7052473
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TXK, Polyclonal Antibody

★Popular Item★
 Also Known As   

TXK Antibody

 Product Synonym Names    Tyrosine-protein kinase TXK; Protein-tyrosine kinase 4; Resting lymphocyte kinase; TXK; PTK4; RLK
 Product Gene Name   

anti-TXK antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    L27071 mRNA
 3D Structure    ModBase 3D Structure for P42681
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Rat
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Tyrosine-protein kinase TXK protein (32-83AA)
 Conjugation    Non-conjugated
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, pH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TXK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TXK antibody

   Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.
 Applications Tested/Suitable for anti-TXK antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-TXK antibody    WB: 1:500-1:5000
IHC: 1:20-1:200
IF: 1:50-1:200
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 Western Blot (WB) of anti-TXK antibody    Western Blot
Positive WB detected in: HEK293 whole cell lysate,Jurkat whole cell lysate,Rat liver tissue,Rat stomach tissue
All lanes: TXK antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 62 KDa
Observed band size: 62 KDa

anti-TXK antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TXK antibody    Immunohistochemistry of paraffin-embedded human lymph node tissue using MBS7052473 at dilution of 1:100
anti-TXK antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-TXK antibody    Immunohistochemistry of paraffin-embedded human breast cancer using MBS7052473 at dilution of 1:100
anti-TXK antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-TXK antibody    Immunofluorescent analysis of HepG2 cells using MBS7052473 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-TXK antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for TXK. It may not necessarily be applicable to this product.
 NCBI GI #    148596974
 NCBI GeneID    7294
 NCBI Accession #    NP_003319.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003328.2 [Other Products]
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 UniProt Primary Accession #    P42681 [Other Products]
 UniProt Secondary Accession #    Q14220 [Other Products]
 UniProt Related Accession #    P42681 [Other Products]
 Molecular Weight    61,258 Da
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 NCBI Official Full Name    tyrosine-protein kinase TXK
 NCBI Official Synonym Full Names    TXK tyrosine kinase
 NCBI Official Symbol    TXK [Similar Products]
 NCBI Official Synonym Symbols   
RLK; TKL; BTKL; PTK4; PSCTK5
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase TXK
 UniProt Protein Name    Tyrosine-protein kinase TXK
 UniProt Synonym Protein Names   
Protein-tyrosine kinase 4; Resting lymphocyte kinase
 Protein Family    Tyrosine-protein kinase
 UniProt Gene Name    TXK [Similar Products]
 UniProt Synonym Gene Names    PTK4; RLK [Similar Products]
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 UniProt Comments for TXK    TXK: Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T- cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskekleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell- specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr- 201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor. Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.

Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Tec family

Chromosomal Location of Human Ortholog: 4p12

Cellular Component: cytoplasm; extrinsic to internal side of plasma membrane; nucleus

Molecular Function: protein binding; receptor binding

Biological Process: adaptive immune response; cell differentiation; cytokine production; integrin-mediated signaling pathway; phospholipase C activation; positive regulation of interferon-gamma production; positive regulation of transcription from RNA polymerase II promoter; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; T cell receptor signaling pathway; tissue regeneration; transmembrane receptor protein tyrosine kinase signaling pathway
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 Research Articles on TXK    1. These data indicate that PRN694 is a highly selective and potent covalent inhibitor of ITK and RLK, and its extended target residence time enables durable attenuation of effector cells in vitro and in vivo.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TXK antibodyPathways associated with anti-TXK antibody
 Reference Product  PubMed Publications
 PIK3R1 antibody  >1 publications with TXK and PIK3R1
 Products by Pathway  Pathway Diagram
 FCERI Mediated Ca+2 Mobilization Pathway antibodies  FCERI Mediated Ca+2 Mobilization Pathway Diagram
 Fc Epsilon Receptor (FCERI) Signaling Pathway antibodies  Fc Epsilon Receptor (FCERI) Signaling Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
Diseases associated with anti-TXK antibodyOrgans/Tissues associated with anti-TXK antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >2 publications with TXK and Necrosis
 Respiratory Hypersensitivity Antibodies  >1 publications with TXK and Respiratory Hypersensitivity
 Death Antibodies  >1 publications with TXK and Death
 Kidney Diseases Antibodies  >1 publications with TXK and Kidney Diseases
 Lung Diseases Antibodies  >1 publications with TXK and Lung Diseases
 Inflammation Antibodies  >1 publications with TXK and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >37 publications with TXK and Blood
 Thymus Antibodies  >6 publications with TXK and Thymus
 Bone Marrow Antibodies  >3 publications with TXK and Bone Marrow
 Spleen Antibodies  >2 publications with TXK and Spleen
 Embryonic Tissue Antibodies  >2 publications with TXK and Embryonic Tissue
 Lymph Node Antibodies  >1 publications with TXK and Lymph Node
 Muscle Antibodies  >1 publications with TXK and Muscle
 Lung Antibodies  >1 publications with TXK and Lung
 Liver Antibodies  >1 publications with TXK and Liver
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