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anti-Tau antibody :: Rabbit Tau Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9407579
Unit / Price
0.05 mL  /  $200 +1 FREE 8GB USB
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tau, Polyclonal Antibody

★Popular Item★
 Also Known As   

Tau (Phospho-Thr181) Antibody

 Product Synonym Names    MAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau
 Product Gene Name   

anti-Tau antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    157140
 3D Structure    ModBase 3D Structure for P10636
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    The antibody detects endogenous level of Tau only when phosphorylated at threonine 181.
 Purity/Purification    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
 Form/Format    Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1.0 mg/ml (lot specific)
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 Immunogen Type    Peptide-KLH
 Immunogen Description    Peptide sequence around phosphorylation site of threonine 181 (P-K-T(p)-P-P) derived from Human Tau.
 Modification    Phospho-Thr181
 Target Name    Tau
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 Preparation and Storage    Store at -20 degree C for long term preservation (recommended). Store at 4 degree C for short term use.
 Other Notes    Small volumes of anti-Tau antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Tau antibody

   Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
 Product Categories/Family for anti-Tau antibody    Phospho-specific Ab
 Applications Tested/Suitable for anti-Tau antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-Tau antibody    Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
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 Western Blot (WB) of anti-Tau antibody    Western blot analysis of extracts from mouse brain tissue using Tau(Phospho-Thr181) Antibody and the same antibody preincubated with blocking peptide.
anti-Tau antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-Tau antibody    Immunohistochemical analysis of paraffin-embedded rat hippocampal region tissue from a model with Alzheimer
anti-Tau antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for Tau. It may not necessarily be applicable to this product.
 NCBI GI #    294862258
 NCBI GeneID    4137
 NCBI Accession #    NP_001116538.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001123066.3 [Other Products]
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 UniProt Primary Accession #    P10636 [Other Products]
 UniProt Secondary Accession #    P18518; Q14799; Q15549; Q15550; Q15551; Q1RMF6; Q53YB1; Q5CZI7; Q5XWF0; Q6QT54; Q9UDJ3 [Other Products]
 UniProt Related Accession #    P10636 [Other Products]
 Molecular Weight    80,941 Da
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 NCBI Official Full Name    microtubule-associated protein tau isoform 6
 NCBI Official Synonym Full Names    microtubule-associated protein tau
 NCBI Official Symbol    MAPT [Similar Products]
 NCBI Official Synonym Symbols   
TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103
[Similar Products]
 NCBI Protein Information    microtubule-associated protein tau
 UniProt Protein Name    Microtubule-associated protein tau
 UniProt Synonym Protein Names   
Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau
 Protein Family    Tautomerase
 UniProt Gene Name    MAPT [Similar Products]
 UniProt Synonym Gene Names    MAPTL; MTBT1; TAU; PHF-tau [Similar Products]
 UniProt Entry Name    TAU_HUMAN
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 NCBI Summary for Tau    This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
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 UniProt Comments for Tau    Tau: a microtubule-associated protein that regulates microtubule assembly and stability. Apparently involved in the establishment and maintenance of neuronal polarity. Mutations can result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. Nine differentially spliced isoforms have been described. The short isoforms allow plasticity of the cytoskeleton, whereas the longer isoforms may preferentially play a role in its stabilization.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21.1

Cellular Component: microtubule; microtubule associated complex; growth cone; axon; tubulin complex; plasma membrane; axoneme; cytosol

Molecular Function: protein binding; enzyme binding; structural constituent of cytoskeleton; microtubule binding; apolipoprotein binding; protein kinase binding; SH3 domain binding

Biological Process: apoptosis; axon extension; positive regulation of axon extension; positive regulation of microtubule polymerization; neuron migration; axon cargo transport; microtubule cytoskeleton organization and biogenesis; adult walking behavior; regulation of microtubule polymerization; mitochondrion transport along microtubule; negative regulation of intracellular transport; generation of neurons; regulation of autophagy; cell structure disassembly during apoptosis

Disease: Supranuclear Palsy, Progressive, 1; Pick Disease Of Brain; Frontotemporal Dementia; Parkinson-dementia Syndrome; Parkinson Disease, Late-onset; Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-related
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 Research Articles on Tau    1. findings suggest that truncation/activation of Dyrk1A by Ca(2+)/calpain I might contribute to Tau pathology via promotion of exon 10 exclusion and hyperphosphorylation of Tau in AD brain
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Tau antibodyPathways associated with anti-Tau antibody
 Reference Product  PubMed Publications
 SNCA antibody  >90 publications with Tau and SNCA
 CDK5 antibody  >36 publications with Tau and CDK5
 GSK3B antibody  >14 publications with Tau and GSK3B
 FYN antibody  >8 publications with Tau and FYN
 UBC antibody  >4 publications with Tau and UBC
 YWHAZ antibody  >2 publications with Tau and YWHAZ
 MARK2 antibody  >2 publications with Tau and MARK2
 MAPK8 antibody  >2 publications with Tau and MAPK8
 STUB1 antibody  >2 publications with Tau and STUB1
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway antibodies  Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway Diagram
 IL-2 Signaling Pathway antibodies  IL-2 Signaling Pathway Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
Diseases associated with anti-Tau antibodyOrgans/Tissues associated with anti-Tau antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1224 publications with Tau and Nervous System Diseases
 Neurodegenerative Diseases Antibodies  >1115 publications with Tau and Neurodegenerative Diseases
 Brain Diseases Antibodies  >1104 publications with Tau and Brain Diseases
 Dementia Antibodies  >1016 publications with Tau and Dementia
 Tauopathies Antibodies  >838 publications with Tau and Tauopathies
 Alzheimer Disease Antibodies  >667 publications with Tau and Alzheimer Disease
 Frontotemporal Dementia Antibodies  >410 publications with Tau and Frontotemporal Dementia
 Movement Disorders Antibodies  >290 publications with Tau and Movement Disorders
 Parkinsonian Disorders Antibodies  >216 publications with Tau and Parkinsonian Disorders
 Disease Models, Animal Antibodies  >182 publications with Tau and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >874 publications with Tau and Brain
 Nerve Antibodies  >261 publications with Tau and Nerve
 Vascular Antibodies  >33 publications with Tau and Vascular
 Ganglia Antibodies  >32 publications with Tau and Ganglia
 Muscle Antibodies  >26 publications with Tau and Muscle
 Eye Antibodies  >22 publications with Tau and Eye
 Embryonic Tissue Antibodies  >10 publications with Tau and Embryonic Tissue
 Kidney Antibodies  >7 publications with Tau and Kidney
 Bone Antibodies  >5 publications with Tau and Bone
 Pancreas Antibodies  >3 publications with Tau and Pancreas
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