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anti-SLC6A6 antibody :: Rabbit anti-Rat Taurine Transporter Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS616155 anti-SLC6A6 antibody
Unit / Price
0.1 mg  /  $745 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Taurine Transporter (SLC6A6), Polyclonal Antibody

 Also Known As   

Taurine Transporter (Tau1, TauT)

 Product Synonym Names    Anti -Taurine Transporter (Tau1, TauT)
 Product Gene Name   

anti-SLC6A6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (14444106..14530857). Location: 3p25-p24
 OMIM    186854
 3D Structure    ModBase 3D Structure for P31641
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Rat
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 Specificity    Recognizes rat Tau1.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.1% BSA.
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 Immunogen    Synthetic peptide consisting of 20aa peptide near the carboxy terminal cytoplasmic region of rat TAU-1. Conjugated to KLH. Species sequence homology: mouse; 100%, human, canine-;90% and bovine; 78%
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-SLC6A6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-SLC6A6 antibody

   Taurine (2-aminoethane sulfonic acid), a beta amino acid with a negatively charged sulfonic group is one of the most abundant amino acids in the brain. It is particularly enriched (millimolar conc.) in excitable tissues, particularly those that generate oxidants. Taurine is produced by cysteine metabolism and obtained from diet as well. It is a chemically inert molecule with a long turnover rate. It is not incorporated into proteins. It is also thought to play a major role in osmoregulation. It is also postulated to play a critical role in neurotransmission, neuromodulation, and membrane stabilization, neuronal differentiation, migration, synaptogenesis, and development. Taurine is transported to various target tissues by Na-dependent high affinity uptake system carried out by two distinct membrane transporter proteins: a high affinity (Km 40uM) taurine transporter (TAU-1 or TAUT-1) and a beta-alanine and taurine transporter protein (Km 4.5uM) known as TAUT-2. Both TAUT-1/2 share significant sequence homology with the GABA and glycine transporters that are characterized by the presence of 12 transmembrane domains. Taurine transporters are found in brain, retina and many other tissues.
 Product Categories/Family for anti-SLC6A6 antibody    Antibodies; Abs to Transport Proteins
 Applications Tested/Suitable for anti-SLC6A6 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-SLC6A6 antibody    Suitable for use in Immunofluorescence, ELISA, Western Blot and Immunohistochemistry.
Dilution: ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well.
Western Blot: 1-10ug/ml (ECL)
Immunohistochemistry: 2-20ug/ml
Immunofluorescence: 2-20ug/ml
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NCBI/Uniprot data below describe general gene information for SLC6A6. It may not necessarily be applicable to this product.
 NCBI GI #    799339
 NCBI GeneID    6533
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 UniProt Primary Accession #    P31641 [Other Products]
 UniProt Secondary Accession #    Q9BXB0 [Other Products]
 UniProt Related Accession #    P31641; Q59GD7; Q9BRI2; AAB25509 [Other Products]
 Molecular Weight    69,830 Da [Similar Products]
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 NCBI Official Full Name    taurine transporter
 NCBI Official Synonym Full Names    solute carrier family 6 (neurotransmitter transporter, taurine), member 6
 NCBI Official Symbol    SLC6A6 [Similar Products]
 NCBI Official Synonym Symbols   
TAUT; MGC10619; MGC131729
[Similar Products]
 NCBI Protein Information    sodium- and chloride-dependent taurine transporter; OTTHUMP00000208177; OTTHUMP00000208180; solute carrier family 6 member 6
 UniProt Protein Name    Sodium- and chloride-dependent taurine transporter
 UniProt Synonym Protein Names   
Solute carrier family 6 member 6
 Protein Family    Sodium- and chloride-dependent taurine transporter
 UniProt Gene Name    SLC6A6 [Similar Products]
 UniProt Entry Name    SC6A6_HUMAN
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 NCBI Summary for SLC6A6    Taurine (2-aminoethanesulfonic acid) is a major intracellular amino acid in mammals. It is involved in a number of important physiologic processes, including bile acid conjugation in hepatocytes, modulation of calcium flux and neural excitability, osmoregulation, detoxification, and membrane stabilization. The cells of most organisms respond to hypertonicity by the intracellular accumulation of high concentrations of small organic solutes (osmolytes) that, in contrast to high concentrations of electrolytes, do not perturb the function of macromolecules. The renal medulla is normally the only tissue in mammals that undergoes wide shifts in tonicity. Its hypertonicity when the kidney is excreting a concentrated urine is fundamental to water conservation. The taurine content of the renal medulla of rats infused with 5% NaCl is higher than that in controls, suggesting that taurine behaves as an osmolyte in the renal medulla. Indeed, taurine functions as an osmolyte in Madin-Darby canine kidney (MDCK) cells. When MDCK cells cultured in isotonic medium are switched to hypertonic medium, their content of taurine doubles through the taking up of taurine from the medium. Taurine transport in these cells is dependent on sodium and chloride ions and is localized primarily in the basolateral plasma membrane (summary by Uchida et al., 1992 [PubMed 1518851]).[supplied by OMIM]
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 UniProt Comments for SLC6A6    TAUT: Required for the uptake of taurine. Transports both taurine and beta-alanine which requires sodium ions. Chloride ions are necessary for optimal uptake. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.

Protein type: Transporter; Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p25.1

Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: taurine binding; neurotransmitter:sodium symporter activity; taurine:sodium symporter activity

Biological Process: amino acid metabolic process; taurine transport; transport; amino acid transport; neurotransmitter transport; ion transport; transmembrane transport
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 Research Articles on SLC6A6    1. Observational study of gene-disease association. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-SLC6A6 antibodyDiseases associated with anti-SLC6A6 antibody
 Products by Pathway  Pathway Diagram
 Amino Acid Transport Across The Plasma Membrane Pathway antibodies  Amino Acid Transport Across The Plasma Membrane Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Na+/Cl- Dependent Neurotransmitter Transporters Pathway antibodies  Na+/Cl- Dependent Neurotransmitter Transporters Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway antibodies  Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway Diagram
 Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies  Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram
 Disease Name  Pubmed Publications
 Neurodegenerative Diseases Antibodies  >1 publications with SLC6A6 and Neurodegenerative Diseases
 Hypertension Antibodies  >1 publications with SLC6A6 and Hypertension
 Fibrosis Antibodies  >1 publications with SLC6A6 and Fibrosis
Organs/Tissues associated with anti-SLC6A6 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with SLC6A6 and Blood
 Brain Antibodies  >2 publications with SLC6A6 and Brain
 Ganglia Antibodies  >1 publications with SLC6A6 and Ganglia
 Intestine Antibodies  >1 publications with SLC6A6 and Intestine
 Eye Antibodies  >1 publications with SLC6A6 and Eye
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