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anti-TERT antibody :: Rabbit Telomerase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS821835 anti-TERT antibody
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Telomerase (TERT), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-Telomerase Antibody

 Product Synonym Names    EST2; TCS1; TRT; Telomerase reverse transcriptase; HEST2; Telomerase catalytic subunit; Telomerase-associated protein 2; TP2
 Product Gene Name   

anti-TERT antibody

[Similar Products]
 Antibody/Peptide Pairs    Telomerase peptide (MBS824361) is used for blocking the activity of Telomerase antibody (MBS821835)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 615134
 3D Structure    ModBase 3D Structure for O14746
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat, Monkey
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 Specificity    Recognizes endogenous levels of Telomerase protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Telomerase. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-TERT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TERT antibody

   Rabbit polyclonal antibody to Telomerase
 Applications Tested/Suitable for anti-TERT antibody   

Western Blot (WB)

 Application Notes for anti-TERT antibody    WB (1/500 - 1/1000)
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 Western Blot (WB) of anti-TERT antibody    anti-TERT antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TERT. It may not necessarily be applicable to this product.
 NCBI GI #    301129200
 NCBI GeneID    7015
 NCBI Accession #    NP_001180305.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001193376.1 [Other Products]
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 UniProt Primary Accession #    O14746 [Other Products]
 UniProt Secondary Accession #    O14783; Q2XS35; Q8N6C3; Q8NG38; Q8NG46 [Other Products]
 UniProt Related Accession #    O14746 [Other Products]
 Molecular Weight    88,965 Da
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 NCBI Official Full Name    telomerase reverse transcriptase isoform 2
 NCBI Official Synonym Full Names    telomerase reverse transcriptase
 NCBI Official Symbol    TERT [Similar Products]
 NCBI Official Synonym Symbols   
TP2; TRT; CMM9; EST2; TCS1; hTRT; DKCA2; DKCB4; hEST2; PFBMFT1
[Similar Products]
 NCBI Protein Information    telomerase reverse transcriptase; telomerase catalytic subunit; telomerase-associated protein 2
 UniProt Protein Name    Telomerase reverse transcriptase
 UniProt Synonym Protein Names   
HEST2; Telomerase catalytic subunit; Telomerase-associated protein 2; TP2
 Protein Family    Telomerase component
 UniProt Gene Name    TERT [Similar Products]
 UniProt Synonym Gene Names    EST2; TCS1; TRT; TP2 [Similar Products]
 UniProt Entry Name    TERT_HUMAN
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 NCBI Summary for TERT    Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TERT    TERT: telomerase reverse transcriptase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The holoenzyme consists of TERT and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced isoforms have been identified, although the full-length sequence of some variants has not been determined.

Protein type: Nucleolus; DNA-binding; EC 2.7.7.49; Transferase

Chromosomal Location of Human Ortholog: 5p15.33

Cellular Component: nucleoplasm; chromosome, telomeric region; PML body; nuclear telomere cap complex; telomerase holoenzyme complex; nucleolus

Molecular Function: telomerase activity; protein binding; RNA-directed RNA polymerase activity; protein homodimerization activity; DNA binding; metal ion binding; telomeric DNA binding; RNA-directed DNA polymerase activity; telomeric template RNA reverse transcriptase activity; nucleotidyltransferase activity; tRNA binding

Biological Process: mitochondrion organization and biogenesis; DNA strand elongation; RNA-dependent DNA replication; positive regulation of nitric-oxide synthase activity; telomere maintenance via telomerase; age-dependent telomere shortening; positive regulation of Wnt receptor signaling pathway; telomere maintenance; RNA interference, production of siRNA

Disease: Pulmonary Fibrosis, Idiopathic; Aplastic Anemia; Dyskeratosis Congenita, Autosomal Dominant, 1
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 Research Articles on TERT    1. the absence of both EGFR amplification and TERT promoter mutations is associated with longer survival in patients with glioblastomas
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TERT antibodyPathways associated with anti-TERT antibody
 Reference Product  PubMed Publications
 DKC1 antibody  >53 publications with TERT and DKC1
 SP1 antibody  >40 publications with TERT and SP1
 TEP1 antibody  >27 publications with TERT and TEP1
 AKT1 antibody  >14 publications with TERT and AKT1
 SMARCA4 antibody  >9 publications with TERT and SMARCA4
 SMG6 antibody  >2 publications with TERT and SMG6
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Extension Of Telomeres Pathway antibodies  Extension Of Telomeres Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 IL2 Signaling Events Mediated By PI3K Pathway antibodies  IL2 Signaling Events Mediated By PI3K Pathway Diagram
 Id Signaling Pathway antibodies  Id Signaling Pathway Diagram
 RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway antibodies  RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway Diagram
Diseases associated with anti-TERT antibodyOrgans/Tissues associated with anti-TERT antibody
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >398 publications with TERT and Lung Diseases
 Neoplasms, Experimental Antibodies  >331 publications with TERT and Neoplasms, Experimental
 Necrosis Antibodies  >318 publications with TERT and Necrosis
 Inflammation Antibodies  >316 publications with TERT and Inflammation
 Liver Neoplasms Antibodies  >268 publications with TERT and Liver Neoplasms
 Heart Diseases Antibodies  >231 publications with TERT and Heart Diseases
 Lung Neoplasms Antibodies  >213 publications with TERT and Lung Neoplasms
 Reperfusion Injury Antibodies  >208 publications with TERT and Reperfusion Injury
 Cell Transformation, Neoplastic Antibodies  >187 publications with TERT and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >184 publications with TERT and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2632 publications with TERT and Blood
 Lung Antibodies  >721 publications with TERT and Lung
 Embryonic Tissue Antibodies  >180 publications with TERT and Embryonic Tissue
 Uterus Antibodies  >107 publications with TERT and Uterus
 Thymus Antibodies  >91 publications with TERT and Thymus
 Connective Tissue Antibodies  >80 publications with TERT and Connective Tissue
 Lymph Antibodies  >59 publications with TERT and Lymph
 Lymph Node Antibodies  >58 publications with TERT and Lymph Node
 Ascites Antibodies  >16 publications with TERT and Ascites
 Uncharacterized Tissue Antibodies  >4 publications with TERT and Uncharacterized Tissue
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