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anti-TPMT antibody :: Rabbit anti-Human Thiopurine S-methyltransferase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS715275
Western Blot
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Thiopurine S-methyltransferase (TPMT), Polyclonal Antibody

 Also Known As   

Rabbit anti-human Thiopurine S-methyltransferase polyclonal Antibody, Biotin conjugated

 Product Synonym Names    Thiopurine methyltransferase
 Product Gene Name   

anti-TPMT antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    187680
 3D Structure    ModBase 3D Structure for P51580
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Biotin
 Immunogen    Recombinant human Thiopurine S-methyltransferase protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-47507 / sc-47506 / sc-47507 / sc-135249
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TPMT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TPMT antibody

   TPMT is an enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.
 Applications Tested/Suitable for anti-TPMT antibody   

ELISA (EIA)

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 Western Blot of anti-TPMT antibody    anti-TPMT antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for TPMT. It may not necessarily be applicable to this product.
 NCBI GI #    4507653
 NCBI GeneID    7172
 NCBI Accession #    NP_000358.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000367.3 [Other Products]
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 UniProt Primary Accession #    P51580 [Other Products]
 UniProt Secondary Accession #    O14806; O15423; O15424; O15425; O15426; O15515; O15548; O43213; Q5VUK6; Q9UBE6; Q9UBT8 [Other Products]
 UniProt Related Accession #    P51580 [Other Products]
 Molecular Weight    28,180 Da [Similar Products]
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 NCBI Official Full Name    thiopurine S-methyltransferase
 NCBI Official Synonym Full Names    thiopurine S-methyltransferase
 NCBI Official Symbol    TPMT [Similar Products]
 NCBI Protein Information    thiopurine S-methyltransferase
 UniProt Protein Name    Thiopurine S-methyltransferase
 UniProt Synonym Protein Names   
Thiopurine methyltransferase
 Protein Family    Thiopurine S-methyltransferase
 UniProt Gene Name    TPMT [Similar Products]
 UniProt Entry Name    TPMT_HUMAN
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 NCBI Summary for TPMT    This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]
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 UniProt Comments for TPMT    TPMT: Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. Defects in TPMT are the cause of thiopurine S- methyltransferase deficiency (TPMT deficiency). TPMT is an enzyme involved in the normal metabolic inactivation of thiopurine drugs. These drugs are generally used as immunosupressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease and organ transplantation. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs and it is shown that inter-individual differences in response to these drugs are largely determined by genetic variation at the TPMT locus. Belongs to the methyltransferase superfamily. TPMT family.

Protein type: Xenobiotic Metabolism - drug metabolism - other enzymes; EC 2.1.1.67; Methyltransferase

Chromosomal Location of Human Ortholog: 6p22.3

Cellular Component: cytosol

Molecular Function: thiopurine S-methyltransferase activity

Biological Process: methylation; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; xenobiotic metabolic process

Disease: Thiopurine S-methyltransferase Deficiency
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 Research Articles on TPMT    1. Identification of TPMT variants and subsequent dose reduction reduces hematologic events during thiopurine treatment of inflammatory bowel disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TPMT antibodyPathways associated with anti-TPMT antibody
 Reference Product  PubMed Publications
 ITPA antibody  >42 publications with TPMT and ITPA
 HPRT1 antibody  >12 publications with TPMT and HPRT1
 SLC19A1 antibody  >4 publications with TPMT and SLC19A1
 CYP1A2 antibody  >4 publications with TPMT and CYP1A2
 GGH antibody  >2 publications with TPMT and GGH
 XDH antibody  >2 publications with TPMT and XDH
 IMPDH2 antibody  >1 publications with TPMT and IMPDH2
 IMPDH1 antibody  >1 publications with TPMT and IMPDH1
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Methylation Pathway antibodies  Methylation Pathway Diagram
 Phase II Conjugation Pathway antibodies  Phase II Conjugation Pathway Diagram
 Metapathway Biotransformation antibodies  Metapathway Biotransformation Diagram
Diseases associated with anti-TPMT antibodyOrgans/Tissues associated with anti-TPMT antibody
 Disease Name  Pubmed Publications
 Gastrointestinal Diseases Antibodies  >192 publications with TPMT and Gastrointestinal Diseases
 Neutropenia Antibodies  >96 publications with TPMT and Neutropenia
 Leukopenia Antibodies  >77 publications with TPMT and Leukopenia
 Liver Diseases Antibodies  >46 publications with TPMT and Liver Diseases
 Drug-Related Side Effects and Adverse Reactions Antibodies  >41 publications with TPMT and Drug-Related Side Effects and Adverse Reactions
 Thrombocytopenia Antibodies  >15 publications with TPMT and Thrombocytopenia
 Drug-Induced Liver Injury Antibodies  >13 publications with TPMT and Drug-Induced Liver Injury
 Drug Hypersensitivity Antibodies  >13 publications with TPMT and Drug Hypersensitivity
 Necrosis Antibodies  >11 publications with TPMT and Necrosis
 Kidney Diseases Antibodies  >10 publications with TPMT and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >339 publications with TPMT and Blood
 Bone Antibodies  >79 publications with TPMT and Bone
 Bone Marrow Antibodies  >77 publications with TPMT and Bone Marrow
 Liver Antibodies  >71 publications with TPMT and Liver
 Kidney Antibodies  >44 publications with TPMT and Kidney
 Skin Antibodies  >11 publications with TPMT and Skin
 Heart Antibodies  >9 publications with TPMT and Heart
 Lung Antibodies  >5 publications with TPMT and Lung
 Intestine Antibodies  >4 publications with TPMT and Intestine
 Embryonic Tissue Antibodies  >3 publications with TPMT and Embryonic Tissue
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