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anti-TXNRD1 antibody :: Goat Thioredoxin Reductase 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420651
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Thioredoxin Reductase 1 (TXNRD1), Polyclonal Antibody

 Also Known As   

Goat anti-Thioredoxin Reductase 1 Antibody

 Product Synonym Names    TXNRD1; thioredoxin reductase 1; TR1; TXNR; GRIM-12; MGC9145; TR; TRXR1; KM-102-derived reductase-like factor; oxidoreductase; thioredoxin reductase GRIM-12; TXNRD1 antibody; thioredoxin reductase 1 antibody; TR1 antibody; TXNR antibody; GRIM-12 antibody; MGC9145 antibody; TR antibody; TRXR1 antibody; KM-102-derived reductase-like factor antibody; oxidoreductase antibody; thioredoxin reductase GRIM-12 antibody; Thioredoxin Reductase 1; Thioredoxin Reductase 1
 Product Gene Name   

anti-TXNRD1 antibody

[Similar Products]
 Antibody/Peptide Pairs    Thioredoxin Reductase 1 peptide (MBS426105) is used for blocking the activity of Thioredoxin Reductase 1 antibody (MBS420651)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    TKRSGASILQ AGC
 OMIM    601112
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Pig
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence TKRSGASILQAGC, from the C Terminus of the protein sequence according to NP_003321.2; NP_877393.1; NP_877419.1; NP_877420.1; NP_001087240.1.
 Epitope    C Terminus
 Note    This antibody is expected to recognise reported isoform 1 (NP_003321.2), isoform 2 (NP_877393.1; NP_877419.1; NP_877420.1) and isoform 3 (NP_001087240.1)
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-TXNRD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TXNRD1 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-TXNRD1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 60kDa band observed in Human Placenta lysates (predicted MW of 57kDa according to NP_003321). Recommended for use at 0.1-1ug/ml.
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 Western Blot (WB) of anti-TXNRD1 antibody    Staining (0.1ug/ml) of Human Placenta lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
anti-TXNRD1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TXNRD1. It may not necessarily be applicable to this product.
 NCBI GI #    33519432
 NCBI GeneID    7296
 NCBI Accession #    NP_003321.2 [Other Products]
 NCBI Related Accession #    NP_877393.1; NP_877419.1; NP_877420.1; NP_001087240.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003330.2 [Other Products]
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 UniProt Secondary Accession #    Q6FI31; Q6VB40; Q6VB41; Q6VB42; Q6VBP2; Q6VBP3; B7Z1F4; B7Z3Y8; B7Z904; E9PMY9; F5H780 [Other Products]
 UniProt Related Accession #    Q16881 [Other Products]
 Molecular Weight    50,873 Da
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 NCBI Official Full Name    thioredoxin reductase 1
 NCBI Official Synonym Full Names    thioredoxin reductase 1
 NCBI Official Symbol    TXNRD1 [Similar Products]
 NCBI Official Synonym Symbols   
TR; TR1; TXNR; TRXR1; GRIM-12
[Similar Products]
 NCBI Protein Information    thioredoxin reductase 1, cytoplasmic
 UniProt Protein Name    Thioredoxin reductase 1, cytoplasmic
 UniProt Synonym Protein Names   
Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1
 Protein Family    Thioredoxin reductase
 UniProt Gene Name    TXNRD1 [Similar Products]
 UniProt Synonym Gene Names    GRIM12; KDRF; TR; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein [Similar Products]
 UniProt Entry Name    TRXR1_HUMAN
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 NCBI Summary for TXNRD1    This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TXNRD1    TRXR1: a cytoplasmic pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine residue which is required for the catalytic activity.

Protein type: EC 1.8.1.9; Nuclear receptor co-regulator; Oxidoreductase; Nucleotide Metabolism - pyrimidine

Chromosomal Location of Human Ortholog: 12q23-q24.1

Cellular Component: cytosol; mitochondrion; nucleus

Molecular Function: electron carrier activity; FAD binding; protein binding; protein disulfide oxidoreductase activity; thioredoxin-disulfide reductase activity

Biological Process: cell proliferation; cell redox homeostasis; mesoderm formation; nucleobase, nucleoside and nucleotide interconversion; response to reactive oxygen species; selenium metabolic process; signal transduction
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 Research Articles on TXNRD1    1. It seems to be involved in the malignant progression of meningiomas.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TXNRD1 antibodyPathways associated with anti-TXNRD1 antibody
 Reference Product  PubMed Publications
 TXN antibody  >20 publications with TXNRD1 and TXN
 SEPHS2 antibody  >4 publications with TXNRD1 and SEPHS2
 Products by Pathway  Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Detoxification Of Reactive Oxygen Species Pathway antibodies  Detoxification Of Reactive Oxygen Species Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Infectious Disease Pathway antibodies  Infectious Disease Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Metabolism Of Ingested H2SeO4 And H2SeO3 Into H2Se Pathway antibodies  Metabolism Of Ingested H2SeO4 And H2SeO3 Into H2Se Pathway Diagram
Diseases associated with anti-TXNRD1 antibodyOrgans/Tissues associated with anti-TXNRD1 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >20 publications with TXNRD1 and Liver Diseases
 Nervous System Diseases Antibodies  >16 publications with TXNRD1 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >14 publications with TXNRD1 and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >14 publications with TXNRD1 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >14 publications with TXNRD1 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >12 publications with TXNRD1 and Liver Neoplasms
 Inflammation Antibodies  >12 publications with TXNRD1 and Inflammation
 Necrosis Antibodies  >12 publications with TXNRD1 and Necrosis
 Lung Diseases Antibodies  >11 publications with TXNRD1 and Lung Diseases
 Poisoning Antibodies  >9 publications with TXNRD1 and Poisoning
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >53 publications with TXNRD1 and Liver
 Blood Antibodies  >28 publications with TXNRD1 and Blood
 Lung Antibodies  >22 publications with TXNRD1 and Lung
 Brain Antibodies  >17 publications with TXNRD1 and Brain
 Kidney Antibodies  >15 publications with TXNRD1 and Kidney
 Muscle Antibodies  >14 publications with TXNRD1 and Muscle
 Heart Antibodies  >13 publications with TXNRD1 and Heart
 Vascular Antibodies  >12 publications with TXNRD1 and Vascular
 Prostate Antibodies  >11 publications with TXNRD1 and Prostate
 Skin Antibodies  >10 publications with TXNRD1 and Skin
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