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anti-TAFI antibody :: Rabbit anti-Mouse Thrombin Activatable Fibrinolysis Inhibitor (TAFI) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2003123 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $105 +1 FREE 8GB USB
0.02 mg  /  $125 +1 FREE 8GB USB
0.05 mg  /  $170 +1 FREE 8GB USB
0.1 mg  /  $210 +1 FREE 8GB USB
0.2 mg  /  $315 +1 FREE 8GB USB
1 mg  /  $745 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Thrombin Activatable Fibrinolysis Inhibitor (TAFI), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Thrombin Activatable Fibrinolysis Inhibitor (TAFI)

 Product Gene Name   

anti-TAFI antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q9JHH6
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse
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 Specificity    The antibody is aRabbit polyclonalantibody raised againstTAFI. It has been selected for its ability to recognizeTAFI in immunohistochemical staining and western blotting.
 Purity/Purification    Antigen-specific Affinity Chromatography
 Form/Format    Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol
 Concentration    200g/mL (lot specific)
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 Source    Polyclonal antibody preparation
 Traits    Liquid
 Immunogen    Recombinant TAFI (Pro187~Lys327) expressed in E.coli
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2045055
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 4C for frequent use.
Aliquot and store at -20C for 12 months.
Stability Test:The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of anti-TAFI antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TAFI antibody   

WB; IHC; ICC; IP

 Application Notes for anti-TAFI antibody    Western blotting: 0.5-2g/mL
Immunohistochemistry: 5-20g/mL
Immunocytochemistry: 5-20g/mL

Optimal working dilutions must be determined by end user
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 Western Blot (WB) of anti-TAFI antibody    (Figure. Western Blot; Sample: Recombinant TAFI, Mouse.)
anti-TAFI antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TAFI antibody    (Figure. DAB staining on IHC-P; Samples: Mouse Intestine Tissue.)
anti-TAFI antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-TAFI antibody    (Figure. DAB staining on IHC-P; Samples: Mouse Kidney Tissue.)
anti-TAFI antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-TAFI antibody    (Figure. DAB staining on IHC-P; Samples: Mouse Testis Tissue.)
anti-TAFI antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-TAFI antibody    (Figure. DAB staining on IHC-P; Samples: Mouse Brain Tissue.)
anti-TAFI antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TAFI. It may not necessarily be applicable to this product.
 NCBI GI #    31982712
 NCBI GeneID    56373
 NCBI Accession #    NP_062749.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_019775.3 [Other Products]
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 UniProt Primary Accession #    Q9JHH6 [Other Products]
 UniProt Secondary Accession #    Q5EBI3; Q9QZF0 [Other Products]
 UniProt Related Accession #    Q9JHH6 [Other Products]
 Molecular Weight    48,871 Da
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 NCBI Official Full Name    carboxypeptidase B2 preproprotein
 NCBI Official Synonym Full Names    carboxypeptidase B2 (plasma)
 NCBI Official Symbol    Cpb2 [Similar Products]
 NCBI Official Synonym Symbols   
CPR; Cpu; TAFI; AI255929; 1110032P04Rik; 4930405E17Rik
[Similar Products]
 NCBI Protein Information    carboxypeptidase B2
 UniProt Protein Name    Carboxypeptidase B2
 UniProt Synonym Protein Names   
Carboxypeptidase R; CPR; Carboxypeptidase U; CPU; Thrombin-activable fibrinolysis inhibitor; TAFI
 UniProt Gene Name    Cpb2 [Similar Products]
 UniProt Synonym Gene Names    Tafi; CPR; CPU; TAFI [Similar Products]
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 NCBI Summary for TAFI    This gene encodes carboxypeptidase B, a zinc-dependent metalloprotease that cleaves peptide bonds at the C-terminus of protein substrates. The encoded preproprotein undergoes proteolytic activation to generate a mature, functional enzyme, and secreted into plasma. [provided by RefSeq, Jan 2016]
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 UniProt Comments for TAFI    CPB2: Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. Belongs to the peptidase M14 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.17.20; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14|14 D3

Cellular Component: extracellular region; extracellular space

Molecular Function: carboxypeptidase activity; hydrolase activity; metal ion binding; metallocarboxypeptidase activity; metallopeptidase activity; peptidase activity; zinc ion binding

Biological Process: blood coagulation; fibrinolysis; hemostasis; negative regulation of fibrinolysis; proteolysis; response to heat
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 Research Articles on TAFI    1. Results indicate that TAFIa could be a novel biomarker and realistic therapeutic target of chronic thromboembolic pulmonary hypertension.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-TAFI antibodyDiseases associated with anti-TAFI antibody
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >17 publications with TAFI and Inflammation
 Cardiovascular Diseases Antibodies  >13 publications with TAFI and Cardiovascular Diseases
 Necrosis Antibodies  >13 publications with TAFI and Necrosis
 Vascular Diseases Antibodies  >10 publications with TAFI and Vascular Diseases
 Liver Diseases Antibodies  >5 publications with TAFI and Liver Diseases
 Carcinoma Antibodies  >4 publications with TAFI and Carcinoma
 Edema Antibodies  >3 publications with TAFI and Edema
 Hepatitis Antibodies  >3 publications with TAFI and Hepatitis
 Carcinoma, Hepatocellular Antibodies  >2 publications with TAFI and Carcinoma, Hepatocellular
 Atherosclerosis Antibodies  >2 publications with TAFI and Atherosclerosis
Organs/Tissues associated with anti-TAFI antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >15 publications with TAFI and Liver
 Muscle Antibodies  >4 publications with TAFI and Muscle
 Lung Antibodies  >2 publications with TAFI and Lung
 Testis Antibodies  >1 publications with TAFI and Testis
 Embryonic Tissue Antibodies  >1 publications with TAFI and Embryonic Tissue
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