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Sheep Thrombin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS512152 anti-Thrombin antibody
Unit / Price
0.1 mg  /  $375 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Thrombin, Polyclonal Antibody

 Also Known As   

Sheep anti-human Thrombin (FIIa), FITC-Conjugated Affinity-Purified IgG

 Product Synonym Names    Thrombin, human
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Polyclonal
 Host    Sheep
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 Specificity    Prior to conjugation, this antibody was specific for thrombin (including prothrombin) as demonstrated by immunoelectrophoresis and ELISA.
 Purity/Purification    Affinity purified, FITC conjugated IgG.
Vial containing mL of affinity-purified IgG conjugated to fluorescein isothiocyanate (FITC). Total protein is 0.1 mg.
 Form/Format    APIgG-FITC conjugate as a clear yellow liquid.
 Concentration    APIgG-FITC concentration is mg/mL, determined by absorbance using an extinction coefficient (E1%280) of 14. (lot specific)
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 Immunogen    Thrombin prepared from purified human prothrombin, active site blocked with PPACK.
 Buffer    Phosphate-buffered saline containing 1 mg/mL bovine albumin and 0.1% sodium azide (w/v), pH 7.4.
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 Preparation and Storage    Store at 2 degree C to 8 degree C and protect from light.
 Other Notes    Small volumes of anti-Thrombin antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-Thrombin antibody

   Thrombin (EC3.4.21.5, alpha-thrombin) is the product of proteolytic activation of the zymogen prothrombin. Human thrombin is a two-chain serine protease with a mass of 37 kDa. The active site is located within the heavy chain. Thrombin has a high specificity for certain arginine bonds in protein substrates. The primary substrate is fibrinogen which thrombin converts to fibrin through the cleavage of four arginyl-glycyl peptide bonds. Thrombin is also an important activator of platelets, factor XIII, Protein C and TAFI (Plasma procarboxypeptidase B). In a positive feedback mechanism, thrombin increases the rate of its own production by activation of factors VIII and V. The rate of thrombin production is subsequently limited indirectly through the activation of Protein C by thrombin, which then inactivates the activated cofactors VIII and V. The binding of thrombin to thrombomodulin on the cell surface dramatically alters thrombin's specificity, increasing it's activity toward Protein C and TAFI, and decreasing it's activity toward fibrinogen and activating cofactors VIII and V. In plasma, thrombin activity is inhibited primarily by antithrombin and to a lesser extent heparin cofactor II. The rate of inhibition by both of these inhibitors is profoundly increased in the presence of optimal concentrations of heparin. Other physiological inhibitors of thrombin in the absence of heparin include alpha2-macroglobulin and alpha1-antitrypsin1-4.
 Application Notes for anti-Thrombin antibody    Suitable as a source of fluorescein labelled antibodies to human thrombin (and prothrombin).
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NCBI/Uniprot data below describe general gene information for Thrombin. It may not necessarily be applicable to this product.
 NCBI GI #    213487
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 NCBI Official Full Name    thrombin
 Protein Family    Thrombin
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Product References and Citations for anti-Thrombin antibody

   1. Mann KG; Prothrombin and Thrombin; in Hemostasis and Thrombosis, 3rd Edition, eds. RW Colman, J Hirsh, VJ Marder and EW Salzman, pp. 184-199, J.B. Lippincott Co., Philadelphia PA, USA, 1994.
2. Stubbs MT, Bode W; A Player of Many Parts: The Spotlight Falls on Thrombin's Structure; Thrombosis Research 69, pp 1-58, 1993.
3. Downing MW, Bloom JW, Mann KG; Comparison of the Inhibition of Thrombin by Three Plasma Protease Inhibitors; Biochemistry 17, pp 2649- 2653, 1978.
4. Weitz JI, Hudoba M, Massel D, Maranganore J, Hirsh J; Clot-bound Thrombin is Protected from Inhibition by Heparin-ATIII but is Susceptible to - ATIII independent Inhibitors; J. Clin. Invest 86, pp 385-391, 1990.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Thrombin antibodyPathways associated with anti-Thrombin antibody
 Reference Product  PubMed Publications
 FLNA antibody  >12 publications with Thrombin and FLNA
 Products by Pathway  Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
Organs/Tissues associated with anti-Thrombin antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >13 publications with Thrombin and Bone
 Connective Tissue Antibodies  >4 publications with Thrombin and Connective Tissue
 Heart Antibodies  >3 publications with Thrombin and Heart
 Muscle Antibodies  >3 publications with Thrombin and Muscle
 Brain Antibodies  >3 publications with Thrombin and Brain
 Vascular Antibodies  >2 publications with Thrombin and Vascular
 Embryonic Tissue Antibodies  >2 publications with Thrombin and Embryonic Tissue
 Ear Antibodies  >1 publications with Thrombin and Ear
 Kidney Antibodies  >1 publications with Thrombin and Kidney
 Umbilical Cord Antibodies  >1 publications with Thrombin and Umbilical Cord
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