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anti-TS antibody :: Rabbit Thymidylate Synthase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS301979
Immunohistochemistry (IHC)
Unit / Price
0.1 mL (Concentrate)  /  $180 +1 FREE 8GB USB
7 mL (RTU)  /  $300 +1 FREE 8GB USB
0.5 mL (Concentrate)  /  $335 +1 FREE 8GB USB
1 mL (Concentrate)  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Thymidylate Synthase (TS), Polyclonal Antibody

 Also Known As   

Rabbit Anti-Human Thymidylate Synthase (TS) Polyclonal Antibody

 Product Gene Name   

anti-TS antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    188350
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
Predicted Reactivity: Bovine, Frog, Mouse, Rabbit, Rat
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 Form/Format    0.1 ml immunogen affinity purified rabbit polyclonal antibody in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
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 Immunogen    Synthetic peptide derived from C-terminus of human TS protein.
 Control Tissue    Colon Carcinoma
 Cellular Localization    Cytoplasm, Nucleus
 Entrez Gene Code    7298
 Pathway    DNA Replication and Repair
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 Preparation and Storage    Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
 Other Notes    Small volumes of anti-TS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TS antibody

   Thymidylate Synthase (TS) (EC 2.1.1.45) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Over expression of TS has been demonstrated in many types of tumors including breast, colon, gastric and melanoma.
 Applications Tested/Suitable for anti-TS antibody   

Immunohistochemistry (IHC) Paraffin

 Application Notes for anti-TS antibody    Immunohistochemistry Procedure
Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:100. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue section in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min. Primary Antibody Incubation: Incubate for 30 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system.
Immunohistochemistry Dilution: 1:100
IHC Positive Control: Colon Carcinoma
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 Immunohistochemistry (IHC) of anti-TS antibody    Human colon carcinoma stained with anti-TS antibody
anti-TS antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TS. It may not necessarily be applicable to this product.
 NCBI GI #    4507751
 NCBI GeneID    7298
 NCBI Accession #    NP_001062.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001071.2 [Other Products]
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 UniProt Secondary Accession #    Q8WYK3; Q8WYK4 [Other Products]
 UniProt Related Accession #    P04818 [Other Products]
 Molecular Weight    36 kDa
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 NCBI Official Full Name    thymidylate synthase
 NCBI Official Synonym Full Names    thymidylate synthetase
 NCBI Official Symbol    TYMS [Similar Products]
 NCBI Official Synonym Symbols   
TS; TMS; HST422
[Similar Products]
 NCBI Protein Information    thymidylate synthase; TSase
 UniProt Protein Name    Thymidylate synthase
 Protein Family    Thymidylate synthase
 UniProt Gene Name    TYMS [Similar Products]
 UniProt Synonym Gene Names    TS; TS; TSase [Similar Products]
 UniProt Entry Name    TYSY_HUMAN
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 NCBI Summary for TS    Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TS    TYMS: an enzyme in the thymidylate synthase family. Polymorphisms serve as prognostic markers for determining modality of treatment in certain cancers. Genotyping helps predict toxicity to 5-FU-based chemotherapy in patients with colorectal cancer and the response to platinum-based chemotherapy in advanced NSCLC. A common polymorphism is a determinant of red blood cell folate and homocysteine concentrations. Homodimer.

Protein type: DNA repair, damage; Cofactor and Vitamin Metabolism - one carbon pool by folate; Nucleotide Metabolism - pyrimidine; Methyltransferase; Mitochondrial; EC 2.1.1.45

Chromosomal Location of Human Ortholog: 18p11.32

Cellular Component: nucleoplasm; mitochondrion; mitochondrial matrix; mitochondrial inner membrane; cytoplasm; nucleolus; cytosol; nucleus

Molecular Function: mRNA binding; protein homodimerization activity; nucleotide binding; drug binding; cofactor binding; thymidylate synthase activity; folic acid binding

Biological Process: uracil metabolic process; circadian rhythm; tetrahydrofolate metabolic process; immortalization of host cell by virus; methylation; developmental growth; response to organophosphorus; response to toxin; response to glucocorticoid stimulus; dTTP biosynthetic process; response to vitamin A; pyrimidine base metabolic process; response to folic acid; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; aging; response to drug; organ regeneration; nucleobase, nucleoside and nucleotide metabolic process; dTMP biosynthetic process; deoxyribonucleoside monophosphate biosynthetic process; G1/S-specific transcription in mitotic cell cycle; response to ethanol; response to cytokine stimulus; cartilage development; pyrimidine nucleoside biosynthetic process; dUMP metabolic process; mitotic cell cycle; response to progesterone stimulus; G1/S transition of mitotic cell cycle
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 Research Articles on TS    1. The toxicity polymorphism in the TYMS region may actually act through ENOSF1
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TS antibodyPathways associated with anti-TS antibody
 Reference Product  PubMed Publications
 DHFR antibody  >35 publications with TS and DHFR
 SHMT1 antibody  >30 publications with TS and SHMT1
 TK1 antibody  >5 publications with TS and TK1
 PCNA antibody  >3 publications with TS and PCNA
 DTYMK antibody  >2 publications with TS and DTYMK
 RRM2 antibody  >2 publications with TS and RRM2
 CDC6 antibody  >1 publications with TS and CDC6
 CDK1 antibody  >1 publications with TS and CDK1
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 E2F Mediated Regulation Of DNA Replication Pathway antibodies  E2F Mediated Regulation Of DNA Replication Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 Fluoropyrimidine Activity Pathway antibodies  Fluoropyrimidine Activity Pathway Diagram
 G1/S Transition Pathway antibodies  G1/S Transition Pathway Diagram
 G1/S-Specific Transcription Pathway antibodies  G1/S-Specific Transcription Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
Diseases associated with anti-TS antibodyOrgans/Tissues associated with anti-TS antibody
 Disease Name  Pubmed Publications
 Digestive System Neoplasms Antibodies  >87 publications with TS and Digestive System Neoplasms
 Carcinoma Antibodies  >70 publications with TS and Carcinoma
 Colorectal Neoplasms Antibodies  >64 publications with TS and Colorectal Neoplasms
 Adenocarcinoma Antibodies  >35 publications with TS and Adenocarcinoma
 Breast Neoplasms Antibodies  >28 publications with TS and Breast Neoplasms
 Lung Neoplasms Antibodies  >22 publications with TS and Lung Neoplasms
 Carcinoma, Squamous Cell Antibodies  >21 publications with TS and Carcinoma, Squamous Cell
 Neoplasms, Experimental Antibodies  >19 publications with TS and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >15 publications with TS and Nervous System Diseases
 Diarrhea Antibodies  >14 publications with TS and Diarrhea
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >73 publications with TS and Blood
 Lung Antibodies  >33 publications with TS and Lung
 Liver Antibodies  >10 publications with TS and Liver
 Stomach Antibodies  >9 publications with TS and Stomach
 Heart Antibodies  >6 publications with TS and Heart
 Bladder Antibodies  >6 publications with TS and Bladder
 Lymph Antibodies  >5 publications with TS and Lymph
 Vascular Antibodies  >5 publications with TS and Vascular
 Lymph Node Antibodies  >5 publications with TS and Lymph Node
 Bone Antibodies  >4 publications with TS and Bone
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