AAH13919.1
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,140 Da
NCBI Official Full Name
Thymidylate synthetase
NCBI Official Synonym Full Names
thymidylate synthetase
NCBI Protein Information
thymidylate synthase
UniProt Protein Name
Thymidylate synthase
UniProt Synonym Gene Names
NCBI Summary for TYMS
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
UniProt Comments for TYMS
TYMS: an enzyme in the thymidylate synthase family. Polymorphisms serve as prognostic markers for determining modality of treatment in certain cancers. Genotyping helps predict toxicity to 5-FU-based chemotherapy in patients with colorectal cancer and the response to platinum-based chemotherapy in advanced NSCLC. A common polymorphism is a determinant of red blood cell folate and homocysteine concentrations. Homodimer.
Protein type: Cofactor and Vitamin Metabolism - one carbon pool by folate; DNA repair, damage; EC 2.1.1.45; Methyltransferase; Mitochondrial; Nucleotide Metabolism - pyrimidine
Chromosomal Location of Human Ortholog: 18p11.32
Cellular Component: cytoplasm; cytosol; mitochondrial inner membrane; mitochondrial matrix; mitochondrion; nucleolus; nucleus
Molecular Function: cofactor binding; drug binding; folic acid binding; nucleotide binding; protein homodimerization activity; thymidylate synthase activity; translation repressor activity, nucleic acid binding
Biological Process: aging; cartilage development; cell growth; cell proliferation; circadian rhythm; developmental growth; dTMP biosynthetic process; dTTP biosynthetic process; dUMP metabolic process; G1/S-specific transcription in mitotic cell cycle; immortalization of host cell by virus; methylation; negative regulation of translation; nucleobase, nucleoside and nucleotide interconversion; response to cytokine; response to drug; response to ethanol; response to folic acid; response to glucocorticoid stimulus; response to organophosphorus; response to progesterone; response to toxin; response to vitamin A; uracil metabolic process
Research Articles on TYMS
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Products associated with anti-TYMS antibody
Pathways associated with anti-TYMS antibody
Diseases associated with anti-TYMS antibody
Organs/Tissues associated with anti-TYMS antibody
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