NP_006278.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,653 Da
NCBI Official Full Name
tissue factor pathway inhibitor isoform a
NCBI Official Synonym Full Names
tissue factor pathway inhibitor
NCBI Protein Information
tissue factor pathway inhibitor
UniProt Protein Name
Tissue factor pathway inhibitor
UniProt Synonym Protein Names
Extrinsic pathway inhibitor; EPI; Lipoprotein-associated coagulation inhibitor; LACI
UniProt Synonym Gene Names
UniProt Entry Name
TFPI1_HUMAN
NCBI Summary for TFPI
This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq, Jul 2008]
UniProt Comments for TFPI
TFPI: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, GPI anchor; Secreted, signal peptide; Inhibitor; Secreted
Chromosomal Location of Human Ortholog: 2q32
Cellular Component: cell surface; endoplasmic reticulum; extracellular region; extracellular space; plasma membrane
Molecular Function: endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity
Biological Process: blood coagulation; blood coagulation, extrinsic pathway
Research Articles on TFPI
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Products associated with anti-TFPI antibody
Pathways associated with anti-TFPI antibody
Diseases associated with anti-TFPI antibody
Organs/Tissues associated with anti-TFPI antibody
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