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anti-TF antibody :: Cavia anti-Rabbit Tissue Factor (TF) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2013793 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) anti-TF antibody
Unit / Price
0.1 mg  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tissue Factor (TF), Polyclonal Antibody

★Popular Item★
 Also Known As   

FITC-linked Antibody to Tissue Factor (TF)

 Product Gene Name   

anti-TF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (94994732..95007413, complement). Location: 1p22-p21
 OMIM    134390
 3D Structure    ModBase 3D Structure for P13726
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Cavia
 Species Reactivity    Rabbit
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 Specificity    The antibody is a cavia polyclonal antibody raised against tissue factor. It has been selected for its ability to recognize tissue factor in immunohistochemical staining and western blotting.
 Purity/Purification    Affinity Chromatography
 Concentration    200ug/ml (lot specific)
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 Immunogen    Tissue factor, Rabbit. Recombinant tissue factor (Ala33~Ala292) with two N-terminal Tags, His-tag and S-tag expressed in E Coli
 Conjugation    FITC
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-TF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-TF antibody    FITC Antibody
 Applications Tested/Suitable for anti-TF antibody   

Immunohistochemistry (IHC) Formalin/Paraffin, Immunocytochemistry (ICC), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-TF antibody    Western Blot: 1:50-400
ICC in formalin fixed cells: 1:50-500
IHC in formalin fixed frozen section||1:50-500
IHC in paraffin section: 1:10-100
ELISA: 1:100-200
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NCBI/Uniprot data below describe general gene information for TF. It may not necessarily be applicable to this product.
 NCBI GI #    339508
 NCBI GeneID    2152
 NCBI Accession #    AAA36734.1 [Other Products]
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 UniProt Primary Accession #    P13726 [Other Products]
 UniProt Secondary Accession #    Q6FHG2; Q86WH4; D3DT47 [Other Products]
 UniProt Related Accession #    P13726 [Other Products]
 Molecular Weight    33,068 Da
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 NCBI Official Full Name    tissue factor
 NCBI Official Synonym Full Names    coagulation factor III (thromboplastin, tissue factor)
 NCBI Official Symbol    F3 [Similar Products]
 NCBI Official Synonym Symbols   
TF; TFA; CD142
[Similar Products]
 NCBI Protein Information    tissue factor
 UniProt Protein Name    Tissue factor
 UniProt Synonym Protein Names   
Coagulation factor III; Thromboplastin
 Protein Family    Tissue factor
 UniProt Gene Name    F3 [Similar Products]
 UniProt Synonym Gene Names    TF [Similar Products]
 UniProt Entry Name    TF_HUMAN
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 NCBI Summary for TF    This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
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 UniProt Comments for TF    F3: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF-alpha, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a component of cellular immune response. Lung, placenta and pancreas. Belongs to the tissue factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p22-p21

Cellular Component: extracellular matrix; extracellular space; cell surface; integral to membrane; plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; protease binding; phospholipid binding

Biological Process: caspase activation; activation of blood coagulation via clotting cascade; positive regulation of protein kinase B signaling cascade; activation of plasma proteins during acute inflammatory response; positive regulation of angiogenesis; blood coagulation, extrinsic pathway; positive regulation of positive chemotaxis; cytokine and chemokine mediated signaling pathway; positive regulation of endothelial cell proliferation; blood coagulation; positive regulation of cell migration
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 Research Articles on TF    1. an interaction between p27(Kip1) and TF in important pathological alterations such as atherosclerosis and vascular remodeling
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TF antibodyPathways associated with anti-TF antibody
 Reference Product  PubMed Publications
 F10 antibody  >16 publications with TF and F10
 IL6 antibody  >2 publications with TF and IL6
 CRP antibody  >2 publications with TF and CRP
 SIRPA antibody  >1 publications with TF and SIRPA
 TFPI antibody  >1 publications with TF and TFPI
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Extrinsic Pathway antibodies  Extrinsic Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with anti-TF antibodyOrgans/Tissues associated with anti-TF antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >617 publications with TF and Neoplasms
 Liver Diseases Antibodies  >601 publications with TF and Liver Diseases
 Fibrosis Antibodies  >577 publications with TF and Fibrosis
 Liver Cirrhosis Antibodies  >472 publications with TF and Liver Cirrhosis
 Inflammation Antibodies  >109 publications with TF and Inflammation
 Fatty Liver Antibodies  >85 publications with TF and Fatty Liver
 Carcinoma, Hepatocellular Antibodies  >82 publications with TF and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >76 publications with TF and Neoplasms, Experimental
 Adenocarcinoma Antibodies  >72 publications with TF and Adenocarcinoma
 Necrosis Antibodies  >65 publications with TF and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >633 publications with TF and Brain
 Muscle Antibodies  >187 publications with TF and Muscle
 Ovary Antibodies  >166 publications with TF and Ovary
 Nerve Antibodies  >148 publications with TF and Nerve
 Kidney Antibodies  >133 publications with TF and Kidney
 Vascular Antibodies  >127 publications with TF and Vascular
 Heart Antibodies  >109 publications with TF and Heart
 Connective Tissue Antibodies  >108 publications with TF and Connective Tissue
 Eye Antibodies  >99 publications with TF and Eye
 Lung Antibodies  >91 publications with TF and Lung
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