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anti-TIMP1 antibody :: Rabbit Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2004700 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Western Blot (WB)
Unit / Price
0.01 mg  /  $100 +1 FREE 8GB USB
0.02 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $145 +1 FREE 8GB USB
0.1 mg  /  $185 +1 FREE 8GB USB
0.2 mg  /  $255 +1 FREE 8GB USB
1 mg  /  $595 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tissue Inhibitors Of Metalloproteinase 1 (TIMP1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Biotin-Linked Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1)

 Product Gene Name   

anti-TIMP1 antibody

[Similar Products]
 Matching Pairs    Unconjugated Antibody: Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) (MBS2004372)
Biotin Conjugated Antibody: Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) (MBS2004700)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS2004700 Technical Datasheet    Technical Datasheet PDF
 Chromosome Location    Chromosome: X; NC_000023.10 (47441690..47446190). Location: Xp11.3-p11.23
 OMIM    305370
 3D Structure    ModBase 3D Structure for P01033
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 Clonality    Polyclonal
 Host    Rabbit
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 Purity/Purification    Antigen-specific Affinity Chromatography
 Form/Format    Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
 Concentration    0.45 mg/ml (lot specific)
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 Organism Species    Mus musculus (Mouse)
 Source    Antibody labeling
 Label    Biotin
 Traits    Liquid
 Immunogen    Recombinant TIMP1 (Ala35~Pro160) expressed in E.coli.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 4C for frequent use.
Aliquot and store at -20C for 12 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37oC for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-TIMP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-TIMP1 antibody    Biotin Antibody
 Applications Tested/Suitable for anti-TIMP1 antibody   

WB; IHC; ICC; IP.

 Application Notes for anti-TIMP1 antibody    Western blotting: 0.5-2)Ug/mL;1:220-900
Immunohistochemistry: 5-20)Ug/mL;1:22-90
Immunocytochemistry: 5-20)Ug/mL;1:22-90

Optimal working dilutions must be determined by end user.
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 Western Blot (WB) of anti-TIMP1 antibody    (Figure. Western Blot; Sample: Recombinant protein.)
anti-TIMP1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TIMP1. It may not necessarily be applicable to this product.
 NCBI GI #    994731
 NCBI GeneID    7076
 NCBI Accession #    AAA75558.1 [Other Products]
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 UniProt Primary Accession #    P01033 [Other Products]
 UniProt Secondary Accession #    Q14252; Q9UCU1 [Other Products]
 UniProt Related Accession #    P01033 [Other Products]
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 NCBI Official Full Name    tissue inhibitor of metalloproteinase 1, partial
 NCBI Official Synonym Full Names    TIMP metallopeptidase inhibitor 1
 NCBI Official Symbol    TIMP1 [Similar Products]
 NCBI Official Synonym Symbols   
EPA; EPO; HCI; CLGI; TIMP
[Similar Products]
 NCBI Protein Information    metalloproteinase inhibitor 1; TIMP-1; collagenase inhibitor; erythroid potentiating activity; erythroid-potentiating activity; fibroblast collagenase inhibitor; tissue inhibitor of metalloproteinases 1
 UniProt Protein Name    Metalloproteinase inhibitor 1
 UniProt Synonym Protein Names   
Erythroid-potentiating activity; EPA; Fibroblast collagenase inhibitor; Collagenase inhibitor; Tissue inhibitor of metalloproteinases 1
 Protein Family    Metalloproteinase inhibitor
 UniProt Gene Name    TIMP1 [Similar Products]
 UniProt Synonym Gene Names    CLGI; TIMP; EPA; Collagenase inhibitor; TIMP-1 [Similar Products]
 UniProt Entry Name    TIMP1_HUMAN
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 NCBI Summary for TIMP1    This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TIMP1    TIMP1: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14. Belongs to the protease inhibitor I35 (TIMP) family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: Xp11.3-p11.23

Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region; basement membrane

Molecular Function: metalloendopeptidase inhibitor activity; protein binding; growth factor activity; protease binding; metal ion binding; cytokine activity

Biological Process: response to peptide hormone stimulus; platelet activation; negative regulation of metalloenzyme activity; extracellular matrix organization and biogenesis; response to hormone stimulus; negative regulation of membrane protein ectodomain proteolysis; extracellular matrix disassembly; platelet degranulation; response to cytokine stimulus; positive regulation of cell proliferation; blood coagulation; aging; negative regulation of apoptosis
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 Research Articles on TIMP1    1. There is no difference in the placental TIMP1 and TIMP2 levels in women delivering preterm and at term.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TIMP1 antibodyPathways associated with anti-TIMP1 antibody
 Reference Product  PubMed Publications
 MMP9 antibody  >240 publications with TIMP1 and MMP9
 MMP2 antibody  >220 publications with TIMP1 and MMP2
 MMP1 antibody  >124 publications with TIMP1 and MMP1
 MMP3 antibody  >66 publications with TIMP1 and MMP3
 TGFB1 antibody  >59 publications with TIMP1 and TGFB1
 MMP14 antibody  >21 publications with TIMP1 and MMP14
 SERPINE1 antibody  >17 publications with TIMP1 and SERPINE1
 FN1 antibody  >10 publications with TIMP1 and FN1
 EGF antibody  >6 publications with TIMP1 and EGF
 Products by Pathway  Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 Matrix Metalloproteinases Pathway antibodies  Matrix Metalloproteinases Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
Diseases associated with anti-TIMP1 antibodyOrgans/Tissues associated with anti-TIMP1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >199 publications with TIMP1 and Neoplasms
 Fibrosis Antibodies  >128 publications with TIMP1 and Fibrosis
 Inflammation Antibodies  >115 publications with TIMP1 and Inflammation
 Cardiovascular Diseases Antibodies  >111 publications with TIMP1 and Cardiovascular Diseases
 Vascular Diseases Antibodies  >79 publications with TIMP1 and Vascular Diseases
 Necrosis Antibodies  >67 publications with TIMP1 and Necrosis
 Liver Diseases Antibodies  >64 publications with TIMP1 and Liver Diseases
 Heart Diseases Antibodies  >58 publications with TIMP1 and Heart Diseases
 Female Urogenital Diseases Antibodies  >45 publications with TIMP1 and Female Urogenital Diseases
 Liver Cirrhosis Antibodies  >40 publications with TIMP1 and Liver Cirrhosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >199 publications with TIMP1 and Blood
 Vascular Antibodies  >99 publications with TIMP1 and Vascular
 Liver Antibodies  >95 publications with TIMP1 and Liver
 Muscle Antibodies  >81 publications with TIMP1 and Muscle
 Lung Antibodies  >77 publications with TIMP1 and Lung
 Bone Antibodies  >68 publications with TIMP1 and Bone
 Heart Antibodies  >64 publications with TIMP1 and Heart
 Connective Tissue Antibodies  >50 publications with TIMP1 and Connective Tissue
 Embryonic Tissue Antibodies  >50 publications with TIMP1 and Embryonic Tissue
 Kidney Antibodies  >50 publications with TIMP1 and Kidney
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