BAA00881.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
tissue plasminogen activator
NCBI Official Synonym Full Names
plasminogen activator, tissue
NCBI Protein Information
tissue-type plasminogen activator; alteplase; reteplase; OTTHUMP00000225783; OTTHUMP00000225784; OTTHUMP00000225785; OTTHUMP00000225786; OTTHUMP00000225787; OTTHUMP00000225788; t-plasminogen activator; plasminogen activator, tissue type; tissue plasminogen activator (t-PA)
UniProt Protein Name
Tissue-type plasminogen activator
UniProt Entry Name
TPA_HUMAN
NCBI Summary for PLAT
This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq]
UniProt Comments for PLAT
PLAT: Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration. Increased activity of TPA results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of TPA results in hypofibrinolysis that can lead to thrombosis or embolism. Belongs to the peptidase S1 family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted; Protease; Cytoskeletal; EC 3.4.21.68; Motility/polarity/chemotaxis; Vesicle
Chromosomal Location of Human Ortholog: 8p12
Cellular Component: extracellular matrix; extracellular space; cell surface; apical part of cell; cytoplasm; extracellular region; synapse; secretory granule
Molecular Function: protein binding; serine-type endopeptidase activity
Biological Process: negative regulation of proteolysis; response to peptide hormone stimulus; synaptic transmission, glutamatergic; response to cAMP; smooth muscle cell migration; protein modification process; regulation of synaptic plasticity; platelet-derived growth factor receptor signaling pathway; proteolysis; fibrinolysis; response to hypoxia; blood coagulation; transmembrane transport; plasminogen activation
Disease: Thrombophilia, Familial, Due To Decreased Release Of Tissue Plasminogen Activator
Research Articles on PLAT
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Products associated with anti-PLAT antibody
Pathways associated with anti-PLAT antibody
Diseases associated with anti-PLAT antibody
Organs/Tissues associated with anti-PLAT antibody
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