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anti-Tnfsf11 antibody :: Rabbit anti-Mouse Tnfsf11 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7002526
Immunofluorescence (IF)
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tnfsf11, Polyclonal Antibody

★Popular Item★
 Also Known As   

Tnfsf11 Antibody

 Product Synonym Names    Tumor necrosis factor ligand superfamily member 11; Osteoclast differentiation factor; ODF; Osteoprotegerin ligand; OPGL; Receptor activator of nuclear factor kappa-B ligand; RANKL; TNF-related activation-induced cytokine; TRANCE; CD254; Tnfsf11; Opgl; Rankl; Trance
 Product Gene Name   

anti-Tnfsf11 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for O35235
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse
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 Purity/Purification    >95%,Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant mouse Tumor necrosis factor ligand superfamily member 11 protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-Tnfsf11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Tnfsf11 antibody

   Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
 Applications Tested/Suitable for anti-Tnfsf11 antibody   

ELISA (EIA), Immunofluorescence (IF)

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 Immunofluorescence (IF) of anti-Tnfsf11 antibody    Immunofluorescent analysis of HepG2 cells using MBS7002526 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-Tnfsf11 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for Tnfsf11. It may not necessarily be applicable to this product.
 NCBI GI #    114842415
 NCBI GeneID    21943
 NCBI Accession #    NP_035743.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_011613.3 [Other Products]
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 UniProt Primary Accession #    O35235 [Other Products]
 UniProt Secondary Accession #    O35306; Q3TWY5; Q9JJK8; Q9JJK9; Q9R1Y0 [Other Products]
 UniProt Related Accession #    O35235 [Other Products]
 Molecular Weight    22,150 Da
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 NCBI Official Full Name    tumor necrosis factor ligand superfamily member 11
 NCBI Official Synonym Full Names    tumor necrosis factor (ligand) superfamily, member 11
 NCBI Official Symbol    Tnfsf11 [Similar Products]
 NCBI Official Synonym Symbols   
ODF; OPG; OPGL; RANKL; Ly109l; Trance
[Similar Products]
 NCBI Protein Information    tumor necrosis factor ligand superfamily member 11
 UniProt Protein Name    Tumor necrosis factor ligand superfamily member 11
 UniProt Synonym Protein Names   
Osteoclast differentiation factor; ODF
 Protein Family    Tumor necrosis factor ligand superfamily
 UniProt Gene Name    Tnfsf11 [Similar Products]
 UniProt Synonym Gene Names    Opgl; Rankl; Trance; ODF; OPGL; RANKL; TRANCE [Similar Products]
 UniProt Entry Name    TNF11_MOUSE
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 UniProt Comments for Tnfsf11    TNFSF11: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Homotrimer. Up-regulated by T-cell receptor stimulation. Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid. Belongs to the tumor necrosis factor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: cytoplasm; extracellular region; extracellular space; integral to membrane; membrane; plasma membrane

Molecular Function: cytokine activity; protein binding; tumor necrosis factor receptor binding; tumor necrosis factor receptor superfamily binding

Biological Process: activation of JNK activity; activation of NF-kappaB transcription factor; bone resorption; calcium ion homeostasis; cell differentiation; cytokine and chemokine mediated signaling pathway; immune response; lymph node development; mammary gland epithelial cell proliferation; monocyte chemotaxis; multicellular organismal development; organ morphogenesis; ossification; osteoclast differentiation; positive regulation of bone resorption; positive regulation of corticotropin-releasing hormone secretion; positive regulation of homotypic cell-cell adhesion; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; positive regulation of MAP kinase activity; positive regulation of osteoclast differentiation; positive regulation of phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of T cell activation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein homooligomerization; regulation of osteoclast differentiation; tumor necrosis factor-mediated signaling pathway
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 Research Articles on Tnfsf11    1. These findings suggest that RACK1 specifies the RANKL-stimulated activation of p38 MAPK by facilitating the association of MKK6 with TAK1
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Tnfsf11 antibodyPathways associated with anti-Tnfsf11 antibody
 Reference Product  PubMed Publications
 Tnfrsf11a antibody  >1482 publications with Tnfsf11 and Tnfrsf11a
 Tnfrsf11b antibody  >879 publications with Tnfsf11 and Tnfrsf11b
 Fos antibody  >116 publications with Tnfsf11 and Fos
 Traf6 antibody  >87 publications with Tnfsf11 and Traf6
 Runx2 antibody  >66 publications with Tnfsf11 and Runx2
 Stat1 antibody  >8 publications with Tnfsf11 and Stat1
 Pthlh antibody  >7 publications with Tnfsf11 and Pthlh
 Fosl1 antibody  >2 publications with Tnfsf11 and Fosl1
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Osteoblast Pathway antibodies  Osteoblast Pathway Diagram
 Osteoclast Pathway antibodies  Osteoclast Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
Diseases associated with anti-Tnfsf11 antibodyOrgans/Tissues associated with anti-Tnfsf11 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1027 publications with Tnfsf11 and Necrosis
 Osteoporosis Antibodies  >453 publications with Tnfsf11 and Osteoporosis
 Inflammation Antibodies  >248 publications with Tnfsf11 and Inflammation
 Osteolysis Antibodies  >190 publications with Tnfsf11 and Osteolysis
 Cardiovascular Diseases Antibodies  >165 publications with Tnfsf11 and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >92 publications with Tnfsf11 and Breast Neoplasms
 Osteopetrosis Antibodies  >87 publications with Tnfsf11 and Osteopetrosis
 Alveolar Bone Loss Antibodies  >55 publications with Tnfsf11 and Alveolar Bone Loss
 Neoplasm Metastasis Antibodies  >50 publications with Tnfsf11 and Neoplasm Metastasis
 Pain Antibodies  >43 publications with Tnfsf11 and Pain
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >2267 publications with Tnfsf11 and Bone
 Spleen Antibodies  >100 publications with Tnfsf11 and Spleen
 Thymus Antibodies  >19 publications with Tnfsf11 and Thymus
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