NP_035743.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,150 Da
NCBI Official Full Name
tumor necrosis factor ligand superfamily member 11
NCBI Official Synonym Full Names
tumor necrosis factor (ligand) superfamily, member 11
NCBI Official Synonym Symbols
ODF; OPG; OPGL; RANKL; Ly109l; Trance [Similar Products]
NCBI Protein Information
tumor necrosis factor ligand superfamily member 11
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 11
UniProt Synonym Protein Names
Osteoclast differentiation factor; ODF
UniProt Synonym Gene Names
UniProt Entry Name
TNF11_MOUSE
UniProt Comments for Tnfsf11
TNFSF11: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Homotrimer. Up-regulated by T-cell receptor stimulation. Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid. Belongs to the tumor necrosis factor family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Cellular Component: cytoplasm; extracellular region; extracellular space; integral to membrane; membrane; plasma membrane
Molecular Function: cytokine activity; protein binding; tumor necrosis factor receptor binding; tumor necrosis factor receptor superfamily binding
Biological Process: activation of JNK activity; activation of NF-kappaB transcription factor; bone resorption; calcium ion homeostasis; cell differentiation; cytokine and chemokine mediated signaling pathway; immune response; lymph node development; mammary gland epithelial cell proliferation; monocyte chemotaxis; multicellular organismal development; organ morphogenesis; ossification; osteoclast differentiation; positive regulation of bone resorption; positive regulation of corticotropin-releasing hormone secretion; positive regulation of homotypic cell-cell adhesion; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; positive regulation of MAP kinase activity; positive regulation of osteoclast differentiation; positive regulation of phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of T cell activation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein homooligomerization; regulation of osteoclast differentiation; tumor necrosis factor-mediated signaling pathway
Research Articles on Tnfsf11
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Products associated with anti-Tnfsf11 antibody
Pathways associated with anti-Tnfsf11 antibody
Diseases associated with anti-Tnfsf11 antibody
Organs/Tissues associated with anti-Tnfsf11 antibody
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