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anti-Tlr3 antibody :: Rabbit Toll-like Receptor 3 (TLR3) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS194448
Unit / Price
0.05 mg  /  $470 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Toll-like Receptor 3 (TLR3), Polyclonal Antibody

 Also Known As   

Toll-like Receptor 3 (TLR3) Polyclonal Antibody

 Product Synonym Names    Toll-like Receptor 3 (TLR3)
 Product Gene Name   

anti-Tlr3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 16; NC_005115.2 (50112910..50126371). Location: 16q11
 3D Structure    ModBase 3D Structure for Q7TNI8
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 Clonality    Polyclonal
 Host    Rabbit
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 Specificity    Toll-like Receptor 3 (TLR3) [Rabbit polyclonal antibody recognizes human and mouse TLR3]
This antibody recognizes human and mouse TLR3.
 Form/Format    50 ug purified by antigen affinity chromatography in PBS containing 0.02% sodium azide.
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 Antigen    Synthetic peptide corresponding to 15 amino acids near the N-terminus of human TLR3.
 Preservatives    0.02% sodium azide
 Dilutions Instructions    Dilute in PBS or medium which is identical to that used in the assay system.
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 Preparation and Storage    Store at 4 degree C. Avoid freezing.
 Other Notes    Small volumes of anti-Tlr3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Tlr3 antibody

   TLR3 is a 904 aa protein with 24 N-terminal leucine-rich repeat motifs (LRRs) and a molecular weight of 97 kDa. TLR3 is most closely related to TLR5, TLR7, and TLR8, each with 26% overall sequence identity. In vivo, two different sized transcripts for TLR3 are observed suggesting that the mRNA is alternatively spliced to generate two different forms of the protein. TLR3 mRNA is expressed at highest levels in placenta and pancreas. There are conflicting reports regarding the expression of TLR3 in particular leukocyte populations. Some suggest that TLR3 is only expressed by dendritic cells (DCs), while others find that TLR3 is expressed by T or NK cells. While it is generally assumed that TLRs are expressed on the cell surface, it now appears that some, such as TLR3, may be localized intracellularly, perhaps in the lysosomal compartment.
 Product Categories/Family for anti-Tlr3 antibody    Neuroscience and Signal Transduction Antibodies
 Applications Tested/Suitable for anti-Tlr3 antibody   

Western Blot, Immunohistochemistry

 Application Notes for anti-Tlr3 antibody    Western Blotting: use at 1-2ug/ml. A band of approximately 97 kDa is detected.
Immunohistochemistry: formalin-fixed, paraffin-embedded tissues, use at 5ug/ml.
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 Immunohistochemistry of anti-Tlr3 antibody    anti-Tlr3 antibody Immunohistochemistry (IHC) image
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NCBI/Uniprot data below describe general gene information for Tlr3. It may not necessarily be applicable to this product.
 NCBI GI #    38454316
 NCBI GeneID    364594
 NCBI Accession #    NP_942086.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_198791.1 [Other Products]
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 UniProt Primary Accession #    Q7TNI8 [Other Products]
 UniProt Related Accession #    Q7TNI8; Q80Z88 [Other Products]
 Molecular Weight    103,175 Da [Similar Products]
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 NCBI Official Full Name    toll-like receptor 3
 NCBI Official Synonym Full Names    toll-like receptor 3
 NCBI Official Symbol    Tlr3 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    toll-like receptor 3
 UniProt Protein Name    Toll-like receptor 3
 Protein Family    Toll-like receptor
 UniProt Gene Name    Tlr3 [Similar Products]
 UniProt Entry Name    Q7TNI8_RAT
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 NCBI Summary for Tlr3    human homolog induces activation of NF-kappaB; mouse homolog plays a role in the production of inflammatory cytokines [RGD]
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 UniProt Comments for Tlr3    TLR3: a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. Most abundantly expressed in placenta and pancreas. Restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection. Acts via MyD88 and TRAF6, leading to the activation of NF-kappaB and the production of type I interferon.

Protein type: Membrane protein, integral; Receptor, cytokine

Cellular Component: cell surface; lysosomal membrane; cytoplasm; integral to membrane; intracellular

Molecular Function: identical protein binding; transmembrane receptor activity; double-stranded RNA binding; receptor activity

Biological Process: positive regulation of interleukin-12 production; positive regulation of apoptosis; microglial cell activation; positive regulation of JNK cascade; defense response; positive regulation of interferon-alpha biosynthetic process; positive regulation of NF-kappaB import into nucleus; toll-like receptor 3 signaling pathway; activation of NF-kappaB transcription factor; positive regulation of interleukin-8 production; response to exogenous dsRNA; positive regulation of interferon-beta production; positive regulation of interferon type I production; defense response to virus; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; response to virus; male gonad development; response to dsRNA; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of toll-like receptor signaling pathway; positive regulation of chemokine production; positive regulation of chemokine biosynthetic process; positive regulation of interferon-beta biosynthetic process; toll-like receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; I-kappaB phosphorylation; positive regulation of inflammatory response; positive regulation of interferon-gamma biosynthetic process; microglial cell activation during immune response
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 Research Articles on Tlr3    1. Cellular RNA released from necrotic cells can act as an endogenous TLR3 ligand to induce clusterin expression in vitro in vascular smooth muscle cells and in vivo.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Tlr3 antibodyDiseases associated with anti-Tlr3 antibody
 Products by Pathway  Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Innate Immunity Signaling Pathway antibodies  Innate Immunity Signaling Pathway Diagram
 TRAF6 Mediated Induction Of Proinflammatory Cytokines Pathway antibodies  TRAF6 Mediated Induction Of Proinflammatory Cytokines Pathway Diagram
 Toll Like Receptor 3 (TLR3) Cascade Pathway antibodies  Toll Like Receptor 3 (TLR3) Cascade Pathway Diagram
 Toll Receptor Cascades Pathway antibodies  Toll Receptor Cascades Pathway Diagram
 Toll-like Receptor Signaling Pathway antibodies  Toll-like Receptor Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >306 publications with Tlr3 and Inflammation
 Necrosis Antibodies  >217 publications with Tlr3 and Necrosis
 Neoplasms Antibodies  >101 publications with Tlr3 and Neoplasms
 Hepatitis Antibodies  >69 publications with Tlr3 and Hepatitis
 Nervous System Diseases Antibodies  >68 publications with Tlr3 and Nervous System Diseases
 Lung Diseases Antibodies  >49 publications with Tlr3 and Lung Diseases
 Asthma Antibodies  >44 publications with Tlr3 and Asthma
 Skin Diseases Antibodies  >42 publications with Tlr3 and Skin Diseases
 Carcinoma Antibodies  >40 publications with Tlr3 and Carcinoma
 Kidney Diseases Antibodies  >37 publications with Tlr3 and Kidney Diseases
Organs/Tissues associated with anti-Tlr3 antibody
 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >3 publications with Tlr3 and Ovary
 Dorsal Root Ganglion Antibodies  >2 publications with Tlr3 and Dorsal Root Ganglion
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