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anti-TR antibody :: Rabbit anti-Human Tomoregulin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2026100 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $115 +1 FREE 8GB USB
0.02 mg  /  $135 +1 FREE 8GB USB
0.05 mg  /  $190 +1 FREE 8GB USB
0.1 mg  /  $245 +1 FREE 8GB USB
0.2 mg  /  $370 +1 FREE 8GB USB
1 mg  /  $875 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tomoregulin (TR), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Tomoregulin (TR)

 Product Gene Name   

anti-TR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AB017269 mRNA
 3D Structure    ModBase 3D Structure for Q9UIK5
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is aRabbit polyclonalantibody raised againstTR. It has been selected for its ability to recognizeTR in immunohistochemical staining and western blotting.
 Purity/Purification    Antigen-specific Affinity Chromatography
 Form/Format    Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol
 Concentration    200ug/ml (lot specific)
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 Source    Polyclonal antibody preparation
 Traits    Liquid
 Immunogen    Recombinant tomoregulin (Thr52~Arg290) expressed in E.coli
    
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2083845
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of anti-TR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TR antibody   

WB; IHC; ICC; IP.

 Application Notes for anti-TR antibody    Western blotting: 0.5-2g/mL
Immunocytochemistry in formalin fixed cells: 5-20g/mL
Immunohistochemistry in formalin fixed frozen section: 5-20g/mL
Immunohistochemistry in paraffin section: 5-20g/mL

Optimal working dilutions must be determined by end user
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 Western Blot (WB) of anti-TR antibody    (Figure. Western Blot; Sample: Recombinant Tomoregulin, Human.)
anti-TR antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TR antibody    (Used in DAB staining on formalin fixed paraffin- embedded Kidney tissue)
anti-TR antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TR. It may not necessarily be applicable to this product.
 NCBI GI #    762205498
 NCBI GeneID    23671
 NCBI Accession #    NP_001292063.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001305134.1 [Other Products]
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 UniProt Primary Accession #    Q9UIK5 [Other Products]
 UniProt Secondary Accession #    Q2FA44; Q4ZFW4; Q53H90; Q53RE1; Q8N2R5; Q9NR15; Q9NSS5; Q9P2Y9; Q9UK65 [Other Products]
 UniProt Related Accession #    Q9UIK5 [Other Products]
 Molecular Weight    19,472 Da
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 NCBI Official Full Name    tomoregulin-2 isoform 2
 NCBI Official Synonym Full Names    transmembrane protein with EGF like and two follistatin like domains 2
 NCBI Official Symbol    TMEFF2 [Similar Products]
 NCBI Official Synonym Symbols   
TR; HPP1; TPEF; TR-2; TENB2; CT120.2
[Similar Products]
 NCBI Protein Information    tomoregulin-2
 UniProt Protein Name    Tomoregulin-2
 UniProt Synonym Protein Names   
Hyperplastic polyposis protein 1; Transmembrane protein with EGF-like and two follistatin-like domains
 Protein Family    Tomoregulin
 UniProt Gene Name    TMEFF2 [Similar Products]
 UniProt Synonym Gene Names    HPP1; TENB2; TPEF; TR-2 [Similar Products]
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 NCBI Summary for TR    This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
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 UniProt Comments for TR    TMEFF2: may be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. A member of the Cancer-Testis Antigen (CTA) superfamily. CTAs may play roles in embryonal development and tumor transformation or aspects of tumor progression. CTAs were once thought to be silenced in most normal adult tissues, with limited expression in fetal, placental, testis, and ovarian cells. These proteins are now known to be aberrantly expressed in various cancers and many are capable of eliciting humoral and cellular immune responses. Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques. Down-regulated in tumor cell lines in response to a high level of methylation in the 5' region. The CpG island methylation correlates with TMEFF2 silencing in tumor cell lines. Belongs to the tomoregulin family. Three isoforms of the human protein are produced by alternative splicing. Isoform three is expressed weakly in testis and at high levels in normal and cancerous prostate. Note: This description may include information from RefSeq and UniProtKB

Protein type: Cancer Testis Antigen (CTA); Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q32.3

Cellular Component: extracellular region; integral component of membrane

Biological Process: negative regulation of cell migration; negative regulation of integrin biosynthetic process; negative regulation of stress fiber formation
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 Research Articles on TR    1. Results suggest that TMEFF2 is a brain-enriched endogenous modulator of Abeta neurotoxicity and an enhancer of alpha-secretase processing of AbetaPP
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TR antibodyPathways associated with anti-TR antibody
 Reference Product  PubMed Publications
 RUNX3 antibody  >10 publications with TR and RUNX3
 SARDH antibody  >2 publications with TR and SARDH
 MYC antibody  >2 publications with TR and MYC
 Products by Pathway  Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Repression Pathway antibodies  Validated Targets Of C-MYC Transcriptional Repression Pathway Diagram
Diseases associated with anti-TR antibodyOrgans/Tissues associated with anti-TR antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >16 publications with TR and Adenocarcinoma
 Prostatic Neoplasms Antibodies  >15 publications with TR and Prostatic Neoplasms
 Lung Neoplasms Antibodies  >8 publications with TR and Lung Neoplasms
 Hyperplasia Antibodies  >7 publications with TR and Hyperplasia
 Neoplasm Metastasis Antibodies  >7 publications with TR and Neoplasm Metastasis
 Lung Diseases Antibodies  >6 publications with TR and Lung Diseases
 Respiratory Tract Diseases Antibodies  >6 publications with TR and Respiratory Tract Diseases
 Neoplasms, Experimental Antibodies  >5 publications with TR and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >5 publications with TR and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >5 publications with TR and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >25 publications with TR and Prostate
 Brain Antibodies  >18 publications with TR and Brain
 Lung Antibodies  >9 publications with TR and Lung
 Nerve Antibodies  >7 publications with TR and Nerve
 Intestine Antibodies  >3 publications with TR and Intestine
 Bone Antibodies  >3 publications with TR and Bone
 Embryonic Tissue Antibodies  >3 publications with TR and Embryonic Tissue
 Connective Tissue Antibodies  >1 publications with TR and Connective Tissue
 Eye Antibodies  >1 publications with TR and Eye
 Kidney Antibodies  >1 publications with TR and Kidney
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