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anti-TOP3A antibody :: Rabbit Topoisomerase 3 alpha Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8213918
Western Blot (WB)
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Topoisomerase 3 alpha (TOP3A), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-Topoisomerase 3 alpha Antibody

 Product Synonym Names    TOP3; DNA topoisomerase 3-alpha; DNA topoisomerase III alpha
 Product Gene Name   

anti-TOP3A antibody

[Similar Products]
 Antibody/Peptide Pairs    Topoisomerase 3 alpha peptide (MBS8217663) is used for blocking the activity of Topoisomerase 3 alpha antibody (MBS8213918)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601243
 3D Structure    ModBase 3D Structure for Q13472
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Bovine, Dog, Zebrafish
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 Specificity    Recognizes endogenous levels of Topoisomerase 3 alpha protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Topoisomerase 3 alpha. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-TOP3A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TOP3A antibody

   Rabbit polyclonal antibody to Topoisomerase 3 alpha
 Applications Tested/Suitable for anti-TOP3A antibody   

Western Blot (WB)

 Application Notes for anti-TOP3A antibody    WB (1/500 - 1/1000)
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 Western Blot (WB) of anti-TOP3A antibody    Western blot analysis of Topoisomerase 3 alpha expression in A549 (A), MCF7 (B) whole cell lysates.
anti-TOP3A antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TOP3A. It may not necessarily be applicable to this product.
 NCBI GI #    10835218
 NCBI GeneID    7156
 NCBI Accession #    NP_004609.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004618.3 [Other Products]
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 UniProt Primary Accession #    Q13472 [Other Products]
 UniProt Secondary Accession #    Q13473; A8KA61; B4DK80; D3DXC7 [Other Products]
 UniProt Related Accession #    Q13472 [Other Products]
 Molecular Weight    101,208 Da
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 NCBI Official Full Name    DNA topoisomerase 3-alpha
 NCBI Official Synonym Full Names    topoisomerase (DNA) III alpha
 NCBI Official Symbol    TOP3A [Similar Products]
 NCBI Official Synonym Symbols   
TOP3; ZGRF7
[Similar Products]
 NCBI Protein Information    DNA topoisomerase 3-alpha
 UniProt Protein Name    DNA topoisomerase 3-alpha
 UniProt Synonym Protein Names   
DNA topoisomerase III alpha
 Protein Family    DNA topoisomerase
 UniProt Gene Name    TOP3A [Similar Products]
 UniProt Synonym Gene Names    TOP3 [Similar Products]
 UniProt Entry Name    TOP3A_HUMAN
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 NCBI Summary for TOP3A    This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TOP3A    TOP3A: a DNA topoisomerase. Reduces the number of supercoils in a highly negatively supercoiled DNA. Two alternatively spliced human isoforms have been described.

Protein type: EC 5.99.1.2; Isomerase

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: PML body; chromosome; nucleus

Molecular Function: protein binding; DNA binding; zinc ion binding; DNA topoisomerase type I activity

Biological Process: meiosis; DNA topological change
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 Research Articles on TOP3A    1. The results show that Topo IIIalpha stimulates DNA unwinding by BLM in a manner that is potentiated by RMI1-RMI2, and that the processivity of resection is reliant on the Topo IIIalpha-RMI1-RMI2 complex.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TOP3A antibodyPathways associated with anti-TOP3A antibody
 Reference Product  PubMed Publications
 RMI1 antibody  >3 publications with TOP3A and RMI1
 BLM antibody  >3 publications with TOP3A and BLM
 RMI2 antibody  >2 publications with TOP3A and RMI2
 Products by Pathway  Pathway Diagram
 Bloom's Syndrome Complex Pathway antibodies  Bloom's Syndrome Complex Pathway Diagram
 Bloom's Syndrome Complex Pathway antibodies  Bloom's Syndrome Complex Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Homologous Recombination Pathway antibodies  Homologous Recombination Pathway Diagram
 Homologous Recombination Pathway antibodies  Homologous Recombination Pathway Diagram
 Meiosis Pathway antibodies  Meiosis Pathway Diagram
 Meiotic Recombination Pathway antibodies  Meiotic Recombination Pathway Diagram
Diseases associated with anti-TOP3A antibodyOrgans/Tissues associated with anti-TOP3A antibody
 Disease Name  Pubmed Publications
 Brain Neoplasms Antibodies  >1 publications with TOP3A and Brain Neoplasms
 Breast Neoplasms Antibodies  >1 publications with TOP3A and Breast Neoplasms
 Chromosome Aberrations Antibodies  >1 publications with TOP3A and Chromosome Aberrations
 Nervous System Diseases Antibodies  >1 publications with TOP3A and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with TOP3A and Blood
 Brain Antibodies  >1 publications with TOP3A and Brain
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