NP_006746.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
transaldolase
NCBI Official Synonym Full Names
transaldolase 1
NCBI Protein Information
transaldolase
UniProt Protein Name
Transaldolase
UniProt Synonym Gene Names
UniProt Entry Name
TALDO_HUMAN
NCBI Summary for TALDO1
Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008]
UniProt Comments for TALDO1
TALDO1: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Defects in TALDO1 are the cause of transaldolase 1 deficiency (TALDO1 deficiency). It results in telangiectases of the skin, hepatosplenomegaly, and enlarged clitoris. Belongs to the transaldolase family. Type 1 subfamily.
Protein type: Carbohydrate Metabolism - pentose phosphate pathway; EC 2.2.1.2; Transferase
Chromosomal Location of Human Ortholog: 11p15.5-p15.4
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: monosaccharide binding; protein binding; transaldolase activity
Biological Process: carbohydrate metabolic process; energy reserve metabolic process; fructose 6-phosphate metabolic process; pentose-phosphate shunt; pentose-phosphate shunt, non-oxidative branch; xylulose biosynthetic process
Disease: Transaldolase Deficiency
Research Articles on TALDO1
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Products associated with anti-TALDO1 antibody
Pathways associated with anti-TALDO1 antibody
Diseases associated with anti-TALDO1 antibody
Organs/Tissues associated with anti-TALDO1 antibody
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