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anti-TCEB2 antibody :: Rabbit anti-Human Transcription elongation factor B polypeptide 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1497891
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Transcription elongation factor B polypeptide 2 (TCEB2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Transcription elongation factor B polypeptide 2 polyclonal Antibody(TCEB2)

 Product Synonym Names    Elongin 18 kDa subunit; Elongin-B; EloB; RNA polymerase II transcription factor SIII subunit B; SIII p18; TCEB2
 Product Gene Name   

anti-TCEB2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600787
 3D Structure    ModBase 3D Structure for Q15370
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Transcription elongation factor B polypeptide 2 protein(1-118aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-23407 / sc-23406 / sc-11447
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TCEB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TCEB2 antibody

   SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
 Applications Tested/Suitable for anti-TCEB2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-TCEB2 antibody    Recommended dilution: WB:1:500-5000
IHC:1:20-1:200
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 Western Blot (WB) of anti-TCEB2 antibody    All lanes: Transcription elongation factor B polypeptide 2 antibody at 3ug/ml
Lane 1:k562 whole cell lysate
Lane 2:293T whole cell lysate
Lane 3:HL-60 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 14,18 kDa
Observed band size: 13 kDa

anti-TCEB2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TCEB2 antibody    Immunohistochemistry of paraffin-embedded human colon cancer using MBS1497891 at dilution 1:100
anti-TCEB2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-TCEB2 antibody    Immunohistochemistry of paraffin-embedded human kidney using MBS1497891 at dilution 1:100
anti-TCEB2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TCEB2. It may not necessarily be applicable to this product.
 NCBI GI #    6005890
 NCBI GeneID    6923
 NCBI Accession #    NP_009039.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007108.3 [Other Products]
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 UniProt Primary Accession #    Q15370 [Other Products]
 UniProt Secondary Accession #    B7WPD3 [Other Products]
 UniProt Related Accession #    Q15370 [Other Products]
 Molecular Weight    17,911 Da
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 NCBI Official Full Name    transcription elongation factor B polypeptide 2 isoform a
 NCBI Official Synonym Full Names    transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
 NCBI Official Symbol    TCEB2 [Similar Products]
 NCBI Official Synonym Symbols   
ELOB; SIII
[Similar Products]
 NCBI Protein Information    transcription elongation factor B polypeptide 2
 UniProt Protein Name    Transcription elongation factor B polypeptide 2
 UniProt Synonym Protein Names   
Elongin 18 kDa subunit; Elongin-B; EloB; RNA polymerase II transcription factor SIII subunit B; SIII p18
 Protein Family    Transcription elongation factor B polypeptide
 UniProt Gene Name    TCEB2 [Similar Products]
 UniProt Synonym Gene Names    EloB [Similar Products]
 UniProt Entry Name    ELOB_HUMAN
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 NCBI Summary for TCEB2    This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008]
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 UniProt Comments for TCEB2    TCEB2: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

Chromosomal Location of Human Ortholog: 16p12.3

Cellular Component: Cul2-RING ubiquitin ligase complex; Cul5-RING ubiquitin ligase complex; cytosol; nucleoplasm; VCB complex

Molecular Function: protein binding; ubiquitin protein ligase binding

Biological Process: gene expression; positive regulation of viral transcription; protein complex assembly; protein ubiquitination; RNA elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter; viral reproduction
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 Research Articles on TCEB2    1. The crystal structure of VHL bound to a Cul2 N-terminal domain, Elongin B, and Elongin C.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TCEB2 antibodyPathways associated with anti-TCEB2 antibody
 Reference Product  PubMed Publications
 RBX1 antibody  >3 publications with TCEB2 and RBX1
 CUL2 antibody  >3 publications with TCEB2 and CUL2
 VHL antibody  >3 publications with TCEB2 and VHL
 TCEB1 antibody  >3 publications with TCEB2 and TCEB1
 HIF1A antibody  >2 publications with TCEB2 and HIF1A
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Cellular Response To Hypoxia Pathway antibodies  Cellular Response To Hypoxia Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 ECS Complex Pathway antibodies  ECS Complex Pathway Diagram
 ECS Complex Pathway antibodies  ECS Complex Pathway Diagram
 ECV Complex Pathway antibodies  ECV Complex Pathway Diagram
 ECV Complex Pathway antibodies  ECV Complex Pathway Diagram
Diseases associated with anti-TCEB2 antibodyOrgans/Tissues associated with anti-TCEB2 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >4 publications with TCEB2 and Carcinoma
 Adenocarcinoma Antibodies  >2 publications with TCEB2 and Adenocarcinoma
 Breast Neoplasms Antibodies  >2 publications with TCEB2 and Breast Neoplasms
 Kidney Diseases Antibodies  >2 publications with TCEB2 and Kidney Diseases
 Fatty Liver Antibodies  >1 publications with TCEB2 and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >3 publications with TCEB2 and Kidney
 Blood Antibodies  >1 publications with TCEB2 and Blood
 Adrenal Gland Antibodies  >1 publications with TCEB2 and Adrenal Gland
 Embryonic Tissue Antibodies  >1 publications with TCEB2 and Embryonic Tissue
 Liver Antibodies  >1 publications with TCEB2 and Liver
 Muscle Antibodies  >1 publications with TCEB2 and Muscle
 Brain Antibodies  >1 publications with TCEB2 and Brain
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