NP_001032726.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,699 Da
NCBI Official Full Name
transcription factor BTF3 isoform A
NCBI Official Synonym Full Names
basic transcription factor 3
NCBI Protein Information
transcription factor BTF3
UniProt Protein Name
Transcription factor BTF3
UniProt Synonym Protein Names
Nascent polypeptide-associated complex subunit beta; NAC-beta; RNA polymerase B transcription factor 3
UniProt Synonym Gene Names
UniProt Entry Name
BTF3_HUMAN
NCBI Summary for BTF3
This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
UniProt Comments for BTF3
BTF3: a general transcription factor. BTF3 can form a stable complex with RNA polymerase II. An interaction partner of protein kinase CK2. Required for the initiation of transcription. Expressed at high levels in glioblastoma multiforme. Overexpressed in the microsatellite instability (MIN) phenotypes in colorectal cancer. Up-regulated strongly in the mammary gland during pregnancy, suggesting an involvement in alveolar growth. Two alternatively spliced isoforms have been described.
Protein type: Transcription initiation complex; Transcription factor
Chromosomal Location of Human Ortholog: 5q13.2
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding
Biological Process: in utero embryonic development; protein transport; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter
Research Articles on BTF3
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Diseases associated with anti-BTF3 antibody
Organs/Tissues associated with anti-BTF3 antibody
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