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anti-TEAD3 antibody :: Rabbit anti-Human Transcriptional enhancer factor TEF-5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7001909
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Transcriptional enhancer factor TEF-5 (TEAD3), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Transcriptional enhancer factor TEF-5 polyclonal Antibody

 Product Synonym Names    DTEF-1; TEA domain family member 3; TEAD-3; TEAD3; TEAD5; TEF5
 Product Gene Name   

anti-TEAD3 antibody

[Similar Products]
 Product Synonym Gene Name    TEAD3 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603170
 3D Structure    ModBase 3D Structure for Q99594
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Transcriptional enhancer factor TEF-5 protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-132465 / sc-102130
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TEAD3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TEAD3 antibody

   Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon.
 Product Categories/Family for anti-TEAD3 antibody    Transcription
 Applications Tested/Suitable for anti-TEAD3 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-TEAD3 antibody    Recommended dilution: WB:1:500-2000
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 Immunohistochemistry (IHC) of anti-TEAD3 antibody    IHC image of MBS7001909 diluted at 1:1000 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 degree C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
anti-TEAD3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-TEAD3 antibody    IHC image of MBS7001909 diluted at 1:1000 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 degree C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
anti-TEAD3 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TEAD3. It may not necessarily be applicable to this product.
 NCBI GI #    42490753
 NCBI GeneID    7005
 NCBI Accession #    NP_003205.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003214.3 [Other Products]
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 UniProt Primary Accession #    Q99594 [Other Products]
 UniProt Secondary Accession #    O95910; Q5BJG7; Q8N6Y4 [Other Products]
 UniProt Related Accession #    Q99594 [Other Products]
 Molecular Weight    48,676 Da [Similar Products]
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 NCBI Official Full Name    transcriptional enhancer factor TEF-5
 NCBI Official Synonym Full Names    TEA domain transcription factor 3
 NCBI Official Symbol    TEAD3 [Similar Products]
 NCBI Official Synonym Symbols   
TEF5; TEAD5; TEF-5; DTEF-1; ETFR-1; TEAD-3
[Similar Products]
 NCBI Protein Information    transcriptional enhancer factor TEF-5
 UniProt Protein Name    Transcriptional enhancer factor TEF-5
 UniProt Synonym Protein Names   
DTEF-1; TEA domain family member 3; TEAD-3
 Protein Family    Transcriptional enhancer factor
 UniProt Gene Name    TEAD3 [Similar Products]
 UniProt Synonym Gene Names    TEAD5; TEF5; TEAD-3 [Similar Products]
 UniProt Entry Name    TEAD3_HUMAN
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 NCBI Summary for TEAD3    This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TEAD3    TEAD3: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 6p21.2

Cellular Component: nucleoplasm; transcription factor complex

Molecular Function: DNA binding; protein binding; transcription factor activity

Biological Process: asymmetric neuroblast division; female pregnancy; gene expression; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter
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 Research Articles on TEAD3    1. Sequences at the 9p21.3 risk locus disrupt TEAD factor binding and TEAD3-dependent TGF-beta induction of p16 in HAoSMCs. TEAD3 overexpression induced p16 in HAoSMCs homozygous for the nonrisk coronary disease allele, but not for the risk allele.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TEAD3 antibodyDiseases associated with anti-TEAD3 antibody
 Reference Product  PubMed Publications
 TEAD2 antibody  >6 publications with TEAD3 and TEAD2
 YAP1 antibody  >3 publications with TEAD3 and YAP1
 MYH7 antibody  >1 publications with TEAD3 and MYH7
 MCAT antibody  >1 publications with TEAD3 and MCAT
 WWTR1 antibody  >1 publications with TEAD3 and WWTR1
 Disease Name  Pubmed Publications
 Embryo Loss Antibodies  >1 publications with TEAD3 and Embryo Loss
 Breast Neoplasms Antibodies  >1 publications with TEAD3 and Breast Neoplasms
 Death Antibodies  >1 publications with TEAD3 and Death
 Cardiovascular Diseases Antibodies  >1 publications with TEAD3 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >1 publications with TEAD3 and Kidney Diseases
Organs/Tissues associated with anti-TEAD3 antibody
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >16 publications with TEAD3 and Muscle
 Embryonic Tissue Antibodies  >8 publications with TEAD3 and Embryonic Tissue
 Heart Antibodies  >7 publications with TEAD3 and Heart
 Placenta Antibodies  >6 publications with TEAD3 and Placenta
 Brain Antibodies  >4 publications with TEAD3 and Brain
 Lung Antibodies  >3 publications with TEAD3 and Lung
 Testis Antibodies  >2 publications with TEAD3 and Testis
 Vascular Antibodies  >2 publications with TEAD3 and Vascular
 Adipose Tissue Antibodies  >2 publications with TEAD3 and Adipose Tissue
 Connective Tissue Antibodies  >2 publications with TEAD3 and Connective Tissue
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