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anti-TFRC antibody :: Rabbit anti-Human Transferrin receptor protein 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7000681
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Transferrin receptor protein 1 (TFRC), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Transferrin receptor protein 1 polyclonal Antibody

 Product Synonym Names    T9; p90; CD71; TFRC
 Product Gene Name   

anti-TFRC antibody

[Similar Products]
 Product Synonym Gene Name    TFRC [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    190010
 3D Structure    ModBase 3D Structure for P02786
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Transferrin receptor protein 1 protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-7087 / sc-9099
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TFRC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TFRC antibody

   Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system By similarity. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
 Product Categories/Family for anti-TFRC antibody    Immunology
 Applications Tested/Suitable for anti-TFRC antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-TFRC antibody    Recommended dilution: WB:1:500-2000, IHC:1:20-1:200
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 Western Blot (WB) of anti-TFRC antibody    Western blot
All lanes: Transferrin receptor protein 1 antibody at 2ug/ml
Lane 1:U251 whole cell lysate
Lane 2:293T whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 85kDa
Observed band size: 85kDa

anti-TFRC antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TFRC antibody    Immunohistochemistry of paraffin-embedded human placenta using MBS7000681 at dilution 1:100
anti-TFRC antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-TFRC antibody    Western Blot
Positive WB detected in: Jurkat whole cell lysate
All lanes: TFRC antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 85 KDa
Observed band size: 85 KDa

anti-TFRC antibody Western Blot (WB) (WB) image
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 Immunocytochemistry (IHC) of anti-TFRC antibody    Immunocytochemistry analysis of human colon cancer using MBS7000681 at dilution of 1:100
anti-TFRC antibody Immunocytochemistry (IHC) (ICC) image
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 Immunofluorescence (IF) of anti-TFRC antibody    Immunofluorescent analysis of HepG2 cells using MBS7000681 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-TFRC antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for TFRC. It may not necessarily be applicable to this product.
 NCBI GI #    189458819
 NCBI GeneID    7037
 NCBI Accession #    NP_001121620.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001128148.2 [Other Products]
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 UniProt Primary Accession #    P02786 [Other Products]
 UniProt Secondary Accession #    Q1HE24; Q59G55; Q9UCN0; Q9UCU5; Q9UDF9; Q9UK21; D3DXB0 [Other Products]
 UniProt Related Accession #    P02786 [Other Products]
 Molecular Weight    84,871 Da [Similar Products]
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 NCBI Official Full Name    transferrin receptor protein 1 isoform 1
 NCBI Official Synonym Full Names    transferrin receptor
 NCBI Official Symbol    TFRC [Similar Products]
 NCBI Official Synonym Symbols   
T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46
[Similar Products]
 NCBI Protein Information    transferrin receptor protein 1
 UniProt Protein Name    Transferrin receptor protein 1
 UniProt Synonym Protein Names   
T9; p90; CD_antigen: CD71
 Protein Family    Transferrin receptor protein
 UniProt Gene Name    TFRC [Similar Products]
 UniProt Synonym Gene Names    TR; TfR; TfR1; Trfr; sTfR [Similar Products]
 UniProt Entry Name    TFR1_HUMAN
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 NCBI Summary for TFRC    This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]
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 UniProt Comments for TFRC    TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.

Protein type: Membrane protein, integral; Cell surface; Receptor, misc.

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: basolateral plasma membrane; cell surface; coated pit; cytoplasmic membrane-bound vesicle; endosome; external side of plasma membrane; extracellular region; extracellular space; integral to plasma membrane; intracellular membrane-bound organelle; melanosome; membrane; mitochondrion; perinuclear region of cytoplasm; plasma membrane; recycling endosome; recycling endosome membrane

Molecular Function: chaperone binding; double-stranded RNA binding; glycoprotein binding; Hsp70 protein binding; identical protein binding; protein binding; protein homodimerization activity; transferrin receptor activity; transferrin transmembrane transporter activity; viral receptor activity

Biological Process: acute-phase response; aging; cellular iron ion homeostasis; entry of virus into host cell; osteoclast differentiation; positive regulation of bone resorption; receptor-mediated endocytosis; regulation of cell growth; regulation of cell proliferation; response to copper ion; response to hypoxia; response to iron ion; response to manganese ion; response to nutrient; response to retinoic acid; transferrin transport; transmembrane transport
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 Research Articles on TFRC    1. This study provides insights into the effector functions of human IgG3 in the context of an antibody targeting TfR1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TFRC antibodyPathways associated with anti-TFRC antibody
 Reference Product  PubMed Publications
 HFE antibody  >21 publications with TFRC and HFE
 B2M antibody  >16 publications with TFRC and B2M
 MYC antibody  >14 publications with TFRC and MYC
 SLC40A1 antibody  >10 publications with TFRC and SLC40A1
 FTH1 antibody  >3 publications with TFRC and FTH1
 UBC antibody  >3 publications with TFRC and UBC
 HIF1A antibody  >3 publications with TFRC and HIF1A
 STEAP3 antibody  >2 publications with TFRC and STEAP3
 OPTN antibody  >1 publications with TFRC and OPTN
 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Iron Metabolism In Placenta Pathway antibodies  Iron Metabolism In Placenta Pathway Diagram
Diseases associated with anti-TFRC antibodyOrgans/Tissues associated with anti-TFRC antibody
 Disease Name  Pubmed Publications
 Iron Metabolism Disorders Antibodies  >34 publications with TFRC and Iron Metabolism Disorders
 Disease Models, Animal Antibodies  >17 publications with TFRC and Disease Models, Animal
 Anemia, Iron-Deficiency Antibodies  >12 publications with TFRC and Anemia, Iron-Deficiency
 Inflammation Antibodies  >12 publications with TFRC and Inflammation
 Lung Neoplasms Antibodies  >10 publications with TFRC and Lung Neoplasms
 Liver Diseases Antibodies  >9 publications with TFRC and Liver Diseases
 Breast Neoplasms Antibodies  >8 publications with TFRC and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >7 publications with TFRC and Cardiovascular Diseases
 Colorectal Neoplasms Antibodies  >6 publications with TFRC and Colorectal Neoplasms
 Obesity Antibodies  >6 publications with TFRC and Obesity
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >54 publications with TFRC and Blood
 Liver Antibodies  >30 publications with TFRC and Liver
 Brain Antibodies  >29 publications with TFRC and Brain
 Lung Antibodies  >15 publications with TFRC and Lung
 Intestine Antibodies  >14 publications with TFRC and Intestine
 Bone Antibodies  >14 publications with TFRC and Bone
 Kidney Antibodies  >10 publications with TFRC and Kidney
 Skin Antibodies  >9 publications with TFRC and Skin
 Embryonic Tissue Antibodies  >8 publications with TFRC and Embryonic Tissue
 Vascular Antibodies  >7 publications with TFRC and Vascular
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