NP_001129071.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,573 Da
NCBI Official Full Name
transforming growth factor beta-2 isoform 1
NCBI Official Synonym Full Names
transforming growth factor beta 2
NCBI Protein Information
transforming growth factor beta-2
UniProt Protein Name
Transforming growth factor beta-2
UniProt Synonym Protein Names
BSC-1 cell growth inhibitor; Cetermin; Glioblastoma-derived T-cell suppressor factor; G-TSF
UniProt Synonym Gene Names
NCBI Summary for TGFb2
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]
UniProt Comments for TGFb2
TGFB2: TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth. Homodimer; disulfide-linked. Heterodimers with TGFB1 and with TGFB3 have been found in bone. Interacts with the serine proteases, HTRA1 and HTRA3. Interacts with ASPN. Belongs to the TGF-beta family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell development/differentiation; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q41
Cellular Component: axon; cell soma; extracellular matrix; extracellular region; extracellular space
Molecular Function: amyloid-beta binding; cytokine activity; growth factor activity; protein binding; protein heterodimerization activity; protein homodimerization activity; receptor binding; transforming growth factor beta receptor binding; type II transforming growth factor beta receptor binding
Biological Process: activation of protein kinase activity; angiogenesis; BMP signaling pathway; cardiac muscle cell proliferation; cardioblast differentiation; catagen; cell cycle arrest; cell death; cell development; cell growth; cell migration; cell morphogenesis; cell proliferation; cell-cell junction organization; cell-cell signaling; collagen fibril organization; dopamine biosynthetic process; embryonic development; embryonic gut development; embryonic limb morphogenesis; epithelial to mesenchymal transition; eye development; generation of neurons; glial cell migration; hair follicle development; hair follicle morphogenesis; heart development; heart morphogenesis; hemopoiesis; inner ear development; kidney development; male gonad development; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of immune response; negative regulation of Ras protein signal transduction; neural tube closure; neuron development; neutrophil chemotaxis; odontogenesis; palate development; platelet degranulation; positive regulation of cardioblast differentiation; positive regulation of catagen; positive regulation of cell adhesion mediated by integrin; positive regulation of cell cycle; positive regulation of cell division; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of heart contraction; positive regulation of immune response; positive regulation of integrin biosynthetic process; positive regulation of neuron apoptotic process; positive regulation of ossification; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein secretion; positive regulation of stress-activated MAPK cascade; protein amino acid phosphorylation; regulation of transforming growth factor-beta2 production; response to drug; response to hypoxia; response to progesterone; response to wounding; salivary gland morphogenesis; skeletal system development; SMAD protein import into nucleus; somatic stem cell division; transforming growth factor beta receptor signaling pathway; uterine wall breakdown; uterus development; wound healing
Disease: Loeys-dietz Syndrome 4
Research Articles on TGFb2
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Products associated with anti-TGFb2 antibody
Pathways associated with anti-TGFb2 antibody
Diseases associated with anti-TGFb2 antibody
Organs/Tissues associated with anti-TGFb2 antibody
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