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anti-TMPRSS2 antibody :: Rabbit Transmembrane Protease, Serine 2 (TMPRSS2) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2094884 anti-TMPRSS2 antibody
Unit / Price
0.01 mg  /  $115 +1 FREE 8GB USB
0.02 mg  /  $135 +1 FREE 8GB USB
0.05 mg  /  $190 +1 FREE 8GB USB
0.1 mg  /  $245 +1 FREE 8GB USB
0.2 mg  /  $370 +1 FREE 8GB USB
1 mg  /  $880 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Transmembrane Protease, Serine 2 (TMPRSS2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Biotin-Linked Polyclonal Antibody to Transmembrane Protease, Serine 2 (TMPRSS2)

 Product Synonym Names    PRSS10; Serine protease 10
 Product Gene Name   

anti-TMPRSS2 antibody

[Similar Products]
 Matching Pairs    Unconjugated Antibody: Transmembrane Protease, Serine 2 (TMPRSS2) (MBS2005545)
Biotin Conjugated Antibody: Transmembrane Protease, Serine 2 (TMPRSS2) (MBS2094884)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS2094884 Technical Datasheet    Technical Datasheet PDF
 OMIM    U75329 mRNA
 3D Structure    ModBase 3D Structure for O15393
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 Clonality    Polyclonal
 Host    Rabbit
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 Purity/Purification    Antigen-specific Affinity Chromatography.
 Form/Format    Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
 Concentration    0.47 mg/ml (lot specific)
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 Organism Species    Homo sapiens (Human)
 Source    Antibody labeling
 Label    Biotin
 Traits    Liquid
 Immunogen    Recombinant TMPRSS2 (Ser284~Gly492) expressed in E.coli
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 4C for frequent use.
Aliquot and store at -20C for 12 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-TMPRSS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TMPRSS2 antibody   

WB; IHC; ICC; IP.

 Application Notes for anti-TMPRSS2 antibody    Western blotting: 0.5-2 ug/mL;1:230-940
Immunohistochemistry: 5-20 ug/mL;1:23-94
Immunocytochemistry: 5-20 ug/mL;1:23-94

Optimal working dilutions must be determined by end user.
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NCBI/Uniprot data below describe general gene information for TMPRSS2. It may not necessarily be applicable to this product.
 NCBI GI #    205360943
 NCBI GeneID    7113
 NCBI Accession #    NP_005647.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_005656.3 [Other Products]
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 UniProt Primary Accession #    O15393 [Other Products]
 UniProt Secondary Accession #    Q6GTK7; Q9BXX1; A8K6Z8; B2R8E5; B7Z459; D3DSJ2; F8WES1 [Other Products]
 UniProt Related Accession #    O15393 [Other Products]
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 NCBI Official Full Name    transmembrane protease serine 2 isoform 2
 NCBI Official Synonym Full Names    transmembrane protease, serine 2
 NCBI Official Symbol    TMPRSS2 [Similar Products]
 NCBI Official Synonym Symbols   
PP9284; PRSS10
[Similar Products]
 NCBI Protein Information    transmembrane protease serine 2
 UniProt Protein Name    Transmembrane protease serine 2
 UniProt Synonym Protein Names   
Serine protease 10
 Protein Family    Transmembrane protease serine
 UniProt Gene Name    TMPRSS2 [Similar Products]
 UniProt Synonym Gene Names    PRSS10 [Similar Products]
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 NCBI Summary for TMPRSS2    This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
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 UniProt Comments for TMPRSS2    TMPRSS2: a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Protein type: EC 3.4.21.-; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: integral component of plasma membrane; plasma membrane

Molecular Function: protein binding; scavenger receptor activity; serine-type endopeptidase activity; serine-type peptidase activity

Biological Process: positive regulation of virion penetration into host cell; protein autoprocessing; proteolysis; receptor-mediated endocytosis
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 Research Articles on TMPRSS2    1. We propose that epigenetic events are a significant and alternative driver of aggressive disease in TMPRSS2-ERG fusion-negative prostate cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TMPRSS2 antibodyPathways associated with anti-TMPRSS2 antibody
 Reference Product  PubMed Publications
 ERG antibody  >400 publications with TMPRSS2 and ERG
 ETV1 antibody  >48 publications with TMPRSS2 and ETV1
 ETV4 antibody  >28 publications with TMPRSS2 and ETV4
 SLC45A3 antibody  >14 publications with TMPRSS2 and SLC45A3
 CREBBP antibody  >3 publications with TMPRSS2 and CREBBP
 Products by Pathway  Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Regulation Of Androgen Receptor Activity Pathway antibodies  Regulation Of Androgen Receptor Activity Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
Diseases associated with anti-TMPRSS2 antibodyOrgans/Tissues associated with anti-TMPRSS2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >406 publications with TMPRSS2 and Neoplasms
 Prostatic Neoplasms Antibodies  >393 publications with TMPRSS2 and Prostatic Neoplasms
 Prostatic Diseases Antibodies  >392 publications with TMPRSS2 and Prostatic Diseases
 Adenocarcinoma Antibodies  >64 publications with TMPRSS2 and Adenocarcinoma
 Chromosome Aberrations Antibodies  >46 publications with TMPRSS2 and Chromosome Aberrations
 Hyperplasia Antibodies  >23 publications with TMPRSS2 and Hyperplasia
 Cell Transformation, Neoplastic Antibodies  >18 publications with TMPRSS2 and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >8 publications with TMPRSS2 and Breast Neoplasms
 Inflammation Antibodies  >7 publications with TMPRSS2 and Inflammation
 Precancerous Conditions Antibodies  >7 publications with TMPRSS2 and Precancerous Conditions
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >477 publications with TMPRSS2 and Prostate
 Lung Antibodies  >27 publications with TMPRSS2 and Lung
 Bone Antibodies  >12 publications with TMPRSS2 and Bone
 Kidney Antibodies  >11 publications with TMPRSS2 and Kidney
 Bladder Antibodies  >5 publications with TMPRSS2 and Bladder
 Liver Antibodies  >5 publications with TMPRSS2 and Liver
 Pancreas Antibodies  >4 publications with TMPRSS2 and Pancreas
 Stomach Antibodies  >3 publications with TMPRSS2 and Stomach
 Placenta Antibodies  >2 publications with TMPRSS2 and Placenta
 Trachea Antibodies  >2 publications with TMPRSS2 and Trachea
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