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| Product Name
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Treponema pallidum, Polyclonal Antibody ★Popular Item★
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| Also Known As
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Treponema pallidum
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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| Clonality
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Polyclonal
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| Isotype
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IgG
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| Host
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Rabbit
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| Species Reactivity
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Human
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| Form/Format
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Treponema pallidumid a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
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| Immunogen
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Purified treponema pallidum
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| Localization
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Cell Wall
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| Control
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Infected tissue
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| Reactivity Note
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Paraffin, Frozen
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| Precautions
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1. For professional users only. Ensure results are interpreted by a medical professional. .
2.This product contains sodium azide (NaN3), a toxic chemical which may react with plumbing to form highly explosive build-ups of metal azides. Upon disposal, flush with large volumes of water to prevent sodium azide build-up.
3.Ensure proper handling procedures are used with reagent. Always wear proper laboratory equipment such as laboratory coat and gloves when handling reagents.
4.Unused solution should be disposed of according to local and federal regulations. .
5.Do not ingest reagent. If reagent ingested, contact a poison control center immediately.
6. For complete recommendations for handling biological specimens please refer to the CDC document, “Guidelines for Safe Work Practices in Human and Animal Medical Diagnostic Laboratories”: U.S. Department of Health and Human Services: Centers for Disease Control and Prevention. Guidelines for Safe Work Practices in Human and Animal Medical Diagnostic Laboratories. Supplement / Vol. 61, January 6, 2012.
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| Product Limitations
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Due to inherent variability present in immunohistochemical procedures (including fixation time of tissues, dilution factor of antibody, retrieval method utilized and incubation time), optimal performance should be established through the use of positive and negative controls.
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| Preparation and Storage
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Store at 2-8 °C. Do not use after expiration date listed on package label. Temperature fluctuations should be avoided. Store appropriately when not in use, and avoid prolonged exposure to room temperature conditions.
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| Other Notes
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Small volumes of anti-Treponema pallidum antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Treponema pallidum is a spirochaete bacterium. The treponemes have a cytoplasmic and an outer membrane. The shape of T. pallidum is flat and wavy, unlike the other spirochetes, which are helical. Using light microscopy, treponemes are only visible using dark field illumination. They are Gram negative, but some regard them too thin to be Gram stained. T. pallidum is a motile spirochaete that is generally acquired by close sexual contact, entering the host via breaches in squamous or columnar epithelium. The organism can also be transmitted to a fetus by transplacental passage during the later stages of pregnancy, giving rise to congenital syphilis. The helical structure of T. pallidum allows it to move in a corkscrew motion through a viscous medium such as mucus. It gains access to the host's blood and lymph systems through tissue and mucous membranes.
Detection of Treponema pallidum can be difficult, and the correct diagnosis of secondary syphilis is critical. Diagnosis of syphilis is usually based on clinical presentation, dark-field microscope analysis, and serological tests. T. pallidum can be also evidenced by Immunohistochemistry in up to 90% of the samples with the bacteria located in the epidermis and the upper dermis of formalin-fixed paraffin-embedded tissues.
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| Applications Tested/Suitable for anti-Treponema pallidum antibody
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Immunohistochemistry (IHC) Formalin/Paraffin
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| Application Notes for anti-Treponema pallidum antibody
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This antibody is intended for use in Immunohistochemical applications on formalinfixed paraffin-embedded tissues (FFPE), frozen tissue sections and cell preparations.
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| Dilution Information of anti-Treponema pallidum antibody
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| Immunohistochemistry (IHC) of anti-Treponema pallidum antibody
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IHC of Treponema pallidum on an FFPE Infected Skin Tissue
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Antibody 
