Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow Trk A rightarrow Polyclonal Trk A  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • CHAT Antibody
 • R-spondin family, member 4 (RSPO4) ELISA Kit
 • IL1B Antibody
 • TREM-2 (TREM-2 ) Antibody
 • Hepatocyte Nuclear Factor 1  Alpha (HNF1a) ELISA Kit
 • Fibrillin-1 (FBN1) Recombinant Protein
 • HRAS Recombinant Protein
 • SNAI2 - SLUG Antibody
 • Ub Antibody
 • HIV-1 gp120 Recombinant Protein
 • Proline-Rich AKT1 Substrate 1 (AKT1S1) ELISA Kit
 • CD43 (SPN) Antibody
 • Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) ELISA Kit
 • Uncharacterized electron transport protein ykgF (ykgF) Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-Trk A antibody :: Rabbit Trk A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9401403
Western Blot (WB)
Unit / Price
0.05 mL  /  $200 +1 FREE 8GB USB
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Trk A, Polyclonal Antibody

★Popular Item★
 Also Known As   

Trk A (Phospho-Tyr680/681) Antibody

 Product Synonym Names    High affinity nerve growth factor receptor precursor; NTRK1; Slow nerve growth; TRK; Trk-A
 Product Gene Name   

anti-Trk A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    164970
 3D Structure    ModBase 3D Structure for P04629
Section Bar
 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Specificity    The antibody detects endogenous level of Trk A only when phosphorylated at tyrosine 680/tyrosine 681.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1.0 mg/ml (lot specific)
Section Bar
 Immunogen Type    Peptide-KLH
 Immunogen Description    Peptide sequence around phosphorylation site of tyrosine 680/tyrosine 681 (T-D-Y(p)-Y(p)-R-V) derived from Human Trk A.
 Modification    Phospho-Tyr680/681
 Target Name    Trk A
 Purification    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Section Bar
 Preparation and Storage    Store at -20 degree C/1 year
 Other Notes    Small volumes of anti-Trk A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-Trk A antibody

   Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.Liu HY, et al. (2005) J Biol Chem 280, 19461-71 Wahab NA, Weston BS, Mason RM (2005) J Am Soc Nephrol 16, 340-51 Marsh HN, et al. (2003) J Cell Biol 163, 999-1010
 Product Categories/Family for anti-Trk A antibody    Phospho-specific Ab
 Applications Tested/Suitable for anti-Trk A antibody   

Western Blot (WB)

 Application Notes for anti-Trk A antibody    Western blotting: 1:500~1:1000
Section Bar
 Western Blot (WB) of anti-Trk A antibody    Western blot analysis of extracts from Jurkat cells treated with starved using Phospho-Trk A (Tyr680/Tyr681) antibody.The lane on the right is treated with the antigen-specific peptide.
anti-Trk A antibody Western Blot (WB) (WB) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for Trk A. It may not necessarily be applicable to this product.
 NCBI GI #    56118210
 NCBI GeneID    4914
 NCBI Accession #    NP_001007793.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001007792.1 [Other Products]
Section Bar
 UniProt Primary Accession #    P04629 [Other Products]
 UniProt Secondary Accession #    P08119; Q15655; Q15656; Q5D056; Q5VZS2; Q7Z5C3; Q9UIU7; B2R6T5; B7ZM34 [Other Products]
 UniProt Related Accession #    P04629 [Other Products]
 Molecular Weight    87kd
Table BarTOPTable Bar
 NCBI Official Full Name    high affinity nerve growth factor receptor isoform 3
 NCBI Official Synonym Full Names    neurotrophic tyrosine kinase, receptor, type 1
 NCBI Official Symbol    NTRK1 [Similar Products]
 NCBI Official Synonym Symbols   
MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA
[Similar Products]
 NCBI Protein Information    high affinity nerve growth factor receptor
 UniProt Protein Name    High affinity nerve growth factor receptor
 UniProt Synonym Protein Names   
Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A; Trk-A; gp140trk; p140-TrkA
 UniProt Gene Name    NTRK1 [Similar Products]
 UniProt Synonym Gene Names    MTC; TRK; TRKA; Trk-A [Similar Products]
 UniProt Entry Name    NTRK1_HUMAN
Section Bar
 NCBI Summary for Trk A    This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for Trk A    TrkA: a receptor tyrosine kinase of the Trk family. High affinity receptor for nerve growth factor, neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor. Known substrates include Shc, PI-3K, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system. Two splice variant isoforms have been described.

Protein type: Oncoprotein; EC 2.7.10.1; Membrane protein, integral; Protein kinase, TK; Kinase, protein; Protein kinase, tyrosine (receptor); TK group; Trk family

Chromosomal Location of Human Ortholog: 1q21-q22

Cellular Component: protein complex; cell surface; late endosome membrane; integral to plasma membrane; early endosome; dendrite; cell soma; axon; early endosome membrane; late endosome; plasma membrane; cytoplasmic vesicle; receptor complex; endosome

Molecular Function: neurotrophin p75 receptor binding; neurotrophin binding; protein binding; nerve growth factor receptor activity; protein homodimerization activity; ephrin receptor binding; nerve growth factor binding; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: circadian rhythm; axon guidance; mechanoreceptor differentiation; peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; activation of MAPKK activity; protein amino acid autophosphorylation; protein amino acid phosphorylation; olfactory nerve development; positive regulation of synaptic transmission, glutamatergic; activation of NF-kappaB transcription factor; negative regulation of cell proliferation; sympathetic nervous system development; response to radiation; learning and/or memory; small GTPase mediated signal transduction; response to axon injury; negative regulation of neuron apoptosis; detection of temperature stimulus involved in sensory perception of pain; response to electrical stimulus; response to hydrostatic pressure; aging; response to drug; response to nutrient levels; phosphoinositide-mediated signaling; adenylate cyclase activation; Sertoli cell development; detection of mechanical stimulus involved in sensory perception of pain; positive regulation of programmed cell death; positive regulation of angiogenesis; response to ethanol; phospholipase C activation; B cell differentiation; Ras protein signal transduction; positive regulation of Ras protein signal transduction; response to activity; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Thyroid Carcinoma, Familial Medullary; Insensitivity To Pain, Congenital, With Anhidrosis
Table BarTOPTable Bar
 Research Articles on Trk A    1. Translocations in the NTRK1 gene are recurring events in colorectal cancer, although occurring at a low frequency (around 0.5%).
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-Trk A antibodyPathways associated with anti-Trk A antibody
 Reference Product  PubMed Publications
 NGF antibody  >47 publications with Trk A and NGF
 BDNF antibody  >15 publications with Trk A and BDNF
 NGFR antibody  >11 publications with Trk A and NGFR
 NTF3 antibody  >3 publications with Trk A and NTF3
 FRS2 antibody  >2 publications with Trk A and FRS2
 GRB2 antibody  >1 publications with Trk A and GRB2
 SHC1 antibody  >1 publications with Trk A and SHC1
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activation Of TRKA Receptors Pathway antibodies  Activation Of TRKA Receptors Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Frs2-mediated Activation Pathway antibodies  Frs2-mediated Activation Pathway Diagram
Diseases associated with anti-Trk A antibodyOrgans/Tissues associated with anti-Trk A antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >60 publications with Trk A and Nervous System Diseases
 Peripheral Nervous System Diseases Antibodies  >48 publications with Trk A and Peripheral Nervous System Diseases
 Hereditary Sensory and Autonomic Neuropathies Antibodies  >36 publications with Trk A and Hereditary Sensory and Autonomic Neuropathies
 Neuroblastoma Antibodies  >21 publications with Trk A and Neuroblastoma
 Neoplasms, Experimental Antibodies  >20 publications with Trk A and Neoplasms, Experimental
 Chromosome Aberrations Antibodies  >17 publications with Trk A and Chromosome Aberrations
 Inflammation Antibodies  >9 publications with Trk A and Inflammation
 Lung Diseases Antibodies  >9 publications with Trk A and Lung Diseases
 Lung Neoplasms Antibodies  >9 publications with Trk A and Lung Neoplasms
 Breast Neoplasms Antibodies  >7 publications with Trk A and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >96 publications with Trk A and Nerve
 Brain Antibodies  >31 publications with Trk A and Brain
 Blood Antibodies  >11 publications with Trk A and Blood
 Bone Antibodies  >11 publications with Trk A and Bone
 Prostate Antibodies  >4 publications with Trk A and Prostate
 Bone Marrow Antibodies  >3 publications with Trk A and Bone Marrow
 Liver Antibodies  >3 publications with Trk A and Liver
 Embryonic Tissue Antibodies  >2 publications with Trk A and Embryonic Tissue
 Uncharacterized Tissue Antibodies  >2 publications with Trk A and Uncharacterized Tissue
 Adrenal Gland Antibodies  >2 publications with Trk A and Adrenal Gland
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions