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anti-TNNI3 antibody :: Troponin I-Cardiac (27-39 Region) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS315579 anti-TNNI3 antibody
Unit / Price
1 mg  /  $825 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Troponin I-Cardiac (27-39 Region) (TNNI3), Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat A' Troponin I-Cardiac

 Product Synonym Names    Goat Antibody to Troponin I-Cardiac
 Product Gene Name   

anti-TNNI3 antibody

[Similar Products]
 Matching Pairs    Capture Antibody: Troponin I-Cardiac Clone #P420 (MBS311274)
Detection Antibody: Troponin I-Cardiac (27-39 Region) (MBS315579)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (55663135..55669100, complement). Location: 19q13.4
 OMIM    115210
 3D Structure    ModBase 3D Structure for P19429
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 Clonality    Polyclonal
 Host    Goat of United States origin
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 Specificity    Troponin I-Cardiac (27-39 Region)
Specific for Human Cardiac Troponin I. Recognizes epitopes located in the 27-39 region of Troponin I. Cross reactivity with human skeletal Troponin I is 0.02% by ELISA.
 Purity/Purification    Affinity purified against the 27-39 region of Troponin I-Cardiac
 Form/Format    Affinity Purified, Liquid
 Concentration    5.65mg/ml (OD280nm, E^1% = 13) (lot specific)
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 Immunogen    Highly purified human cardiac Troponin I
 Buffer    10mM Sodium phosphate, 0.85% Sodium chloride, pH 7.2
 Preservative    0.05% Sodium azide
 Important Note    Centrifuge before opening to ensure complete recovery of vial contents.
 Warnings    This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
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 Preparation and Storage    Short-term store at 2 to 8 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TNNI3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-TNNI3 antibody    Polyclonal Antibodies to Cardiac Markers
 Applications Tested/Suitable for anti-TNNI3 antibody   

EIA/ELISA, Immunoassay Antibody Pairs

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NCBI/Uniprot data below describe general gene information for TNNI3. It may not necessarily be applicable to this product.
 NCBI GI #    151101270
 NCBI GeneID    7137
 NCBI Accession #    NP_000354.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_000363.4 [Other Products]
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 UniProt Primary Accession #    P19429 [Other Products]
 UniProt Related Accession #    P19429; Q6FGU5; Q6FGX2 [Other Products]
 Molecular Weight    24,008 Da [Similar Products]
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 NCBI Official Full Name    troponin I, cardiac muscle
 NCBI Official Synonym Full Names    troponin I type 3 (cardiac)
 NCBI Official Symbol    TNNI3 [Similar Products]
 NCBI Official Synonym Symbols   
CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF; MGC116817
[Similar Products]
 NCBI Protein Information    troponin I, cardiac muscle
 UniProt Protein Name    Troponin I, cardiac muscle
 UniProt Synonym Protein Names   
Cardiac troponin I
 Protein Family    Troponin
 UniProt Gene Name    TNNI3 [Similar Products]
 UniProt Synonym Gene Names    TNNC1 [Similar Products]
 UniProt Entry Name    TNNI3_HUMAN
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 NCBI Summary for TNNI3    Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq]
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 UniProt Comments for TNNI3    Function: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Subunit structure: Binds to actin and tropomyosin. Interacts with TRIM63. Ref.7

Involvement in disease: Defects in TNNI3 are the cause of cardiomyopathy familial hypertrophic type 7 (CMH7) [

MIM:613690]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Ref.10 Ref.11 Ref.13 Ref.15 Ref.17Defects in TNNI3 are the cause of cardiomyopathy familial restrictive type 1 (RCM1) [

MIM:115210]. RCM1 is an heart muscle disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.Defects in TNNI3 are the cause of cardiomyopathy dilated type 2A (CMD2A) [

MIM:611880]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Ref.16Defects in TNNI3 are the cause of cardiomyopathy dilated type 1FF (CMD1FF) [

MIM:613286]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.

Sequence similarities: Belongs to the troponin I family.
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 Research Articles on TNNI3    1. Immunoblotting of blood samples from patients with acute ischemic stroke reveals similar degradation patterns of cTnI as has been described in patients with acute myocardial infarction.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TNNI3 antibodyPathways associated with anti-TNNI3 antibody
 Reference Product  PubMed Publications
 TNNT2 antibody  >30 publications with TNNI3 and TNNT2
 TNNC1 antibody  >9 publications with TNNI3 and TNNC1
 TNNI3K antibody  >3 publications with TNNI3 and TNNI3K
 RCAN3 antibody  >2 publications with TNNI3 and RCAN3
 Products by Pathway  Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram
Diseases associated with anti-TNNI3 antibodyOrgans/Tissues associated with anti-TNNI3 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >44 publications with TNNI3 and Cardiovascular Diseases
 Heart Diseases Antibodies  >43 publications with TNNI3 and Heart Diseases
 Cardiomyopathies Antibodies  >39 publications with TNNI3 and Cardiomyopathies
 TROPONIN I, CARDIAC Antibodies  >38 publications with TNNI3 and TROPONIN I, CARDIAC
 Cardiomyopathy, Dilated Antibodies  >14 publications with TNNI3 and Cardiomyopathy, Dilated
 Cardiomegaly Antibodies  >12 publications with TNNI3 and Cardiomegaly
 Heart Failure Antibodies  >9 publications with TNNI3 and Heart Failure
 Hypertension Antibodies  >3 publications with TNNI3 and Hypertension
 Stroke Antibodies  >2 publications with TNNI3 and Stroke
 Fibrosis Antibodies  >2 publications with TNNI3 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >35 publications with TNNI3 and Heart
 Lung Antibodies  >2 publications with TNNI3 and Lung
 Uterus Antibodies  >1 publications with TNNI3 and Uterus
 Embryonic Tissue Antibodies  >1 publications with TNNI3 and Embryonic Tissue
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