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anti-TPSb2 antibody :: Rabbit anti-Human Tryptase Beta 2 (TPSb2) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2005823 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Western Blot (WB)
Unit / Price
0.01 mg  /  $115 +1 FREE 8GB USB
0.02 mg  /  $135 +1 FREE 8GB USB
0.05 mg  /  $190 +1 FREE 8GB USB
0.1 mg  /  $245 +1 FREE 8GB USB
0.2 mg  /  $370 +1 FREE 8GB USB
1 mg  /  $880 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tryptase Beta 2 (TPSb2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Biotin-Linked Antibody to Tryptase Beta 2 (TPSb2)

 Product Gene Name   

anti-TPSb2 antibody

[Similar Products]
 Matching Pairs    Unconjugated Antibody: Tryptase Beta 2 (TPSb2) (MBS2004625)
Biotin Conjugated Antibody: Tryptase Beta 2 (TPSb2) (MBS2005823)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 16; NC_000016.9 (1278336..1280185, complement). Location: 16p13.3
 OMIM    191081
 3D Structure    ModBase 3D Structure for P20231
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against TPSb2. It has been selected for its ability to recognize TPSb2 in immunohistochemical staining and western blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Immunogen    TPSb2, Human
 Immunogen Information    Recombinant TPSb2 (Gln35~Pro275) with N-terminal His-Tag expressed in E.coli.
 Accession No.    RPD781Hu01
 Unconjugated Antibody    The unconjugated antibody version of this item is also available as catalog #MBS2004625
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-TPSb2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-TPSb2 antibody    Biotin Antibody
 Applications Tested/Suitable for anti-TPSb2 antibody   

Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)

 Application Notes for anti-TPSb2 antibody    Western blotting: 1:50-400
Immunocytochemistry in formalin fixed cells: 1:50-500
Immunohistochemistry in formalin fixed frozen section: 1:50-500
Immunohistochemistry in paraffin section: 1:10-100
Enzyme-linked Immunosorbent Assay: 1:100-200
Optimal working dilutions must be determined by end user.
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 Western Blot (WB) of anti-TPSb2 antibody    (Figure. Western Blot; Sample: Recombinant protein.)
anti-TPSb2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TPSb2. It may not necessarily be applicable to this product.
 NCBI GI #    68508970
 NCBI GeneID    64499
 NCBI Accession #    NP_077078.5 [Other Products]
 NCBI GenBank Nucleotide #    NM_024164.5 [Other Products]
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 UniProt Primary Accession #    P20231 [Other Products]
 UniProt Secondary Accession #    O95827; Q15664; Q9UQI6; Q9UQI7; D2E6S0; D2E6S2 [Other Products]
 UniProt Related Accession #    P20231 [Other Products]
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 NCBI Official Full Name    tryptase beta-2
 NCBI Official Synonym Full Names    tryptase beta 2 (gene/pseudogene)
 NCBI Official Symbol    TPSB2 [Similar Products]
 NCBI Official Synonym Symbols   
TPS2; tryptaseB; tryptaseC
[Similar Products]
 NCBI Protein Information    tryptase beta-2; mast cell tryptase beta II; mast cell tryptase beta III
 UniProt Protein Name    Tryptase beta-2
 UniProt Synonym Protein Names   
Tryptase II
 Protein Family    Tryptase
 UniProt Gene Name    TPSB2 [Similar Products]
 UniProt Synonym Gene Names    TPS2; Tryptase-2 [Similar Products]
 UniProt Entry Name    TRYB2_HUMAN
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 NCBI Summary for TPSb2    Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TPSb2    TPSB2: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection. Belongs to the peptidase S1 family. Tryptase subfamily.

Protein type: Protease; EC 3.4.21.59; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: extracellular region

Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity

Biological Process: proteolysis
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 Research Articles on TPSb2    1. Strong linkage of TPSAB1 and TPSB2 and pairing of deficiency alleles with functional alleles in observed haplotypes protect human subjects from "knockout" genomes and indeed from inheritance of fewer than 2 active alleles.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TPSb2 antibodyDiseases associated with anti-TPSb2 antibody
 Reference Product  PubMed Publications
 TPSAB1 antibody  >4 publications with TPSb2 and TPSAB1
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >4 publications with TPSb2 and Inflammation
 Edema Antibodies  >1 publications with TPSb2 and Edema
Organs/Tissues associated with anti-TPSb2 antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1 publications with TPSb2 and Bone
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