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anti-TPS antibody :: Rabbit anti-Human Tryptase (TPS) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2002414 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $105 +1 FREE 8GB USB
0.02 mg  /  $125 +1 FREE 8GB USB
0.05 mg  /  $170 +1 FREE 8GB USB
0.1 mg  /  $220 +1 FREE 8GB USB
0.2 mg  /  $320 +1 FREE 8GB USB
1 mg  /  $760 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tryptase (TPS), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Tryptase (TPS)

 Product Gene Name   

anti-TPS antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below.
MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF - GDVDNDERLP PPFPLKQVKV PIMENHICDA KYHLGAYTGD DVRIVRDDML CAGNTRRDSC QGDSGGPLVC KVNGTWLQAG VVSWGEGCAQ PNRPGIYTRV TY
 OMIM    M30038 mRNA
 3D Structure    ModBase 3D Structure for Q15661
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against TPS. It has been selected for its ability to recognize TPS in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Immunogen    Recombinant TPS (Gly161~Tyr262) expressed in E.coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2051181
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-TPS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TPS antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-TPS antibody    Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
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 Western Blot (WB) of anti-TPS antibody    (Figure. Western Blot; Sample: Mouse Intestine Tissue.)
anti-TPS antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-TPS antibody    (Figure. Western Blot; Sample: Recombinant TPS, Human.)
anti-TPS antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TPS antibody    (Figure. DAB staining on IHC-P; Samples: Human Kidney Cancer Tissue.)
anti-TPS antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-TPS antibody    (Figure. DAB staining on IHC-P; Samples: Human Liver Tissue.)
anti-TPS antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-TPS antibody    (Figure. DAB staining on IHC-P; Samples: Human Liver Cancer Tissue.)
anti-TPS antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-TPS antibody    (Figure. DAB staining on IHC-P; Samples; Human Kidney Tissue.)
anti-TPS antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TPS. It may not necessarily be applicable to this product.
 NCBI GI #    13775595
 NCBI GeneID    7177
 NCBI Accession #    NP_003285.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003294.3 [Other Products]
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 UniProt Primary Accession #    Q15661 [Other Products]
 UniProt Secondary Accession #    P15157; Q15663; Q6B052; Q9H2Y4; Q9H2Y5; Q9UQI1; D2E6R9; D2E6S1 [Other Products]
 UniProt Related Accession #    Q15661 [Other Products]
 Molecular Weight    29,533 Da
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 NCBI Official Full Name    tryptase alpha/beta-1
 NCBI Official Synonym Full Names    tryptase alpha/beta 1
 NCBI Official Symbol    TPSAB1 [Similar Products]
 NCBI Official Synonym Symbols   
TPS1; TPS2; TPSB1
[Similar Products]
 NCBI Protein Information    tryptase alpha/beta-1
 UniProt Protein Name    Tryptase alpha/beta-1
 UniProt Synonym Protein Names   
Tryptase I; Tryptase alpha-1
 Protein Family    Development-specific protein
 UniProt Gene Name    TPSAB1 [Similar Products]
 UniProt Synonym Gene Names    TPS1; TPS2; TPSB1; Tryptase-1 [Similar Products]
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 NCBI Summary for TPS    Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TPS    TPSAB1: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Belongs to the peptidase S1 family. Tryptase subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.21.59; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: extracellular matrix; extracellular region; extracellular space

Molecular Function: protein binding; serine-type endopeptidase activity; serine-type peptidase activity

Biological Process: defense response; extracellular matrix disassembly; proteolysis
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 Research Articles on TPS    1. Increased TPSAB1 copy number is associated with multisystem disorder.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-TPS antibodyDiseases associated with anti-TPS antibody
 Products by Pathway  Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >26 publications with TPS and Inflammation
 Immune System Diseases Antibodies  >19 publications with TPS and Immune System Diseases
 Neoplasms Antibodies  >13 publications with TPS and Neoplasms
 Necrosis Antibodies  >4 publications with TPS and Necrosis
 Hyperplasia Antibodies  >4 publications with TPS and Hyperplasia
 Skin Abnormalities Antibodies  >3 publications with TPS and Skin Abnormalities
 Edema Antibodies  >3 publications with TPS and Edema
 Carcinoma Antibodies  >3 publications with TPS and Carcinoma
 Muscular Diseases Antibodies  >1 publications with TPS and Muscular Diseases
 Weight Loss Antibodies  >1 publications with TPS and Weight Loss
Organs/Tissues associated with anti-TPS antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >20 publications with TPS and Bone
 Lung Antibodies  >19 publications with TPS and Lung
 Connective Tissue Antibodies  >15 publications with TPS and Connective Tissue
 Intestine Antibodies  >8 publications with TPS and Intestine
 Nerve Antibodies  >5 publications with TPS and Nerve
 Liver Antibodies  >5 publications with TPS and Liver
 Kidney Antibodies  >3 publications with TPS and Kidney
 Stomach Antibodies  >3 publications with TPS and Stomach
 Uterus Antibodies  >2 publications with TPS and Uterus
 Lymph Node Antibodies  >2 publications with TPS and Lymph Node
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