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anti-Tsc2 antibody :: Rabbit anti-Human Tsc2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS857700
Testing Data
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
0.05 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tsc2, Polyclonal Antibody

 Also Known As   

Tsc2 (Phospho-Ser1254) Antibody

 Product Gene Name   

anti-Tsc2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    613254
 3D Structure    ModBase 3D Structure for P49815
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Tsc2 (phospho-Ser1254) antibody detects endogenous levels of Tsc2 only when phosphorylated at serine 1254.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    50ug/50ul (lot specific)
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human Tsc2 around the phosphorylation site of serine 1254 (S-L-SP-V-P).
 Pathway    Tumor suppressor
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-Tsc2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-Tsc2 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-Tsc2 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-Tsc2 antibody    WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:4000
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 Testing Data of anti-Tsc2 antibody    P-Peptide - +
Immunohistochemical analysis of paraffin-embedded human prostate carcinoma tissue using Tsc2 (phospho-Ser1254) antibody (E012048).
anti-Tsc2 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for Tsc2. It may not necessarily be applicable to this product.
 NCBI GI #    116256352
 NCBI GeneID    7249
 NCBI Accession #    NP_000539.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000548.3 [Other Products]
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 UniProt Primary Accession #    P49815 [Other Products]
 UniProt Secondary Accession #    O75275; Q4LE71; Q8TAZ1; A7E2E2; B4DIL8; B4DIQ7; B4DRN2; B7Z2B8; C9J378 [Other Products]
 UniProt Related Accession #    P49815 [Other Products]
 Molecular Weight    25,773 Da
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 NCBI Official Full Name    tuberin isoform 1
 NCBI Official Synonym Full Names    tuberous sclerosis 2
 NCBI Official Symbol    TSC2 [Similar Products]
 NCBI Official Synonym Symbols   
LAM; TSC4; PPP1R160
[Similar Products]
 NCBI Protein Information    tuberin; tuberous sclerosis 2 protein; protein phosphatase 1, regulatory subunit 160
 UniProt Protein Name    Tuberin
 UniProt Synonym Protein Names   
Tuberous sclerosis 2 protein
 Protein Family    Tuberin
 UniProt Gene Name    TSC2 [Similar Products]
 UniProt Synonym Gene Names    TSC4 [Similar Products]
 UniProt Entry Name    TSC2_HUMAN
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 NCBI Summary for Tsc2    Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for Tsc2    TSC2: a product of the tumor suppressor gene TSC2. Tuberin and Hamartin (TSC1) form a tumor suppressor heterodimer that inhibits the mTOR nutrient signaling input. TSC1/TSC2 targets the small G protein Rheb, a novel mediator of the nutrient signaling input to mTOR. Functions as a Rheb GTPase activating protein (GAP). Four alternatively spliced isoforms have been described.

Protein type: Cell cycle regulation; Nuclear receptor co-regulator; GAPs, misc.; Tumor suppressor; GAPs

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: TSC1-TSC2 complex; Golgi apparatus; growth cone; cytoskeleton; membrane; cell soma; perinuclear region of cytoplasm; cytoplasm; dendrite; caveola; nucleus; cytosol

Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; GTPase activator activity; phosphatase binding

Biological Process: negative regulation of MAP kinase activity; phosphoinositide 3-kinase cascade; negative regulation of Wnt receptor signaling pathway; regulation of insulin receptor signaling pathway; nerve growth factor receptor signaling pathway; regulation of cell cycle; protein heterooligomerization; heart development; negative regulation of insulin receptor signaling pathway; negative regulation of cell size; negative regulation of cell proliferation; protein localization; cell projection organization and biogenesis; positive chemotaxis; protein import into nucleus; regulation of endocytosis; acute-phase response; protein kinase B signaling cascade; cell cycle arrest; protein homooligomerization; negative regulation of epithelial cell proliferation; epidermal growth factor receptor signaling pathway; negative regulation of TOR signaling pathway; fibroblast growth factor receptor signaling pathway; negative regulation of protein kinase B signaling cascade; phosphoinositide-mediated signaling; endocytosis; vesicle-mediated transport; insulin-like growth factor receptor signaling pathway; glucose import; neural tube closure; response to hypoxia; insulin receptor signaling pathway; negative regulation of protein kinase activity; innate immune response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of phosphoinositide 3-kinase cascade

Disease: Lymphangioleiomyomatosis; Tuberous Sclerosis 2
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Product References and Citations for anti-Tsc2 antibody

   Cai SL, et al. (2006) J Cell Biol 173, 279-89.
Roux PP, et al. (2004) Proc Natl Acad Sci USA 101, 13489-94.
Li Y, Inoki K, Vacratsis P, Guan KL (2003) J Biol Chem 278, 13663-71.
Manning BD, et al. (2002) Mol Cell 10, 151-62.
Goncharova, E. et al. (2002) J. Biol. Chem. 277, 30958-30967.
Aicher, L. D. et al. (2001) J. Biol. Chem. 276, 21017-21021.
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 Research Articles on Tsc2    1. Alpha B-crystallin has an essential role in TSC1/2 complex deficiency-mediated tumorigenesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Tsc2 antibodyPathways associated with anti-Tsc2 antibody
 Reference Product  PubMed Publications
 TSC1 antibody  >872 publications with Tsc2 and TSC1
 MTOR antibody  >625 publications with Tsc2 and MTOR
 RHEB antibody  >162 publications with Tsc2 and RHEB
 AKT1 antibody  >39 publications with Tsc2 and AKT1
 MAPK1 antibody  >10 publications with Tsc2 and MAPK1
 YWHAB antibody  >1 publications with Tsc2 and YWHAB
 Products by Pathway  Pathway Diagram
 AKT Phosphorylates Targets In The Cytosol Pathway antibodies  AKT Phosphorylates Targets In The Cytosol Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
Diseases associated with anti-Tsc2 antibodyOrgans/Tissues associated with anti-Tsc2 antibody
 Disease Name  Pubmed Publications
 Tuberous Sclerosis Antibodies  >1294 publications with Tsc2 and Tuberous Sclerosis
 Kidney Diseases Antibodies  >208 publications with Tsc2 and Kidney Diseases
 Kidney Neoplasms Antibodies  >163 publications with Tsc2 and Kidney Neoplasms
 Epilepsy Antibodies  >157 publications with Tsc2 and Epilepsy
 Brain Diseases Antibodies  >147 publications with Tsc2 and Brain Diseases
 Lymphangioleiomyomatosis Antibodies  >139 publications with Tsc2 and Lymphangioleiomyomatosis
 Seizures Antibodies  >108 publications with Tsc2 and Seizures
 Tuberous Sclerosis 2 Antibodies  >79 publications with Tsc2 and Tuberous Sclerosis 2
 Lung Neoplasms Antibodies  >77 publications with Tsc2 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >72 publications with Tsc2 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >352 publications with Tsc2 and Brain
 Kidney Antibodies  >295 publications with Tsc2 and Kidney
 Muscle Antibodies  >164 publications with Tsc2 and Muscle
 Lung Antibodies  >151 publications with Tsc2 and Lung
 Heart Antibodies  >120 publications with Tsc2 and Heart
 Skin Antibodies  >116 publications with Tsc2 and Skin
 Blood Antibodies  >105 publications with Tsc2 and Blood
 Liver Antibodies  >77 publications with Tsc2 and Liver
 Nerve Antibodies  >36 publications with Tsc2 and Nerve
 Embryonic Tissue Antibodies  >31 publications with Tsc2 and Embryonic Tissue
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