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anti-TUBB antibody :: Rabbit Tubulin-beta Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS301665
Immunohistochemistry (IHC)
Unit / Price
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 Product Name   

Tubulin-beta (TUBB), Polyclonal Antibody

 Also Known As   

Rabbit Anti-Human Tubulin Beta Polyclonal Antibody

 Product Gene Name   

anti-TUBB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    191130
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
Predicted Reactivity: Bovine, Chicken, Frog, Hamster, Mouse, Pig, Rat
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 Form/Format    0.1 ml immunogen affinity purified rabbit polyclonal antibody in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
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 Immunogen    Synthetic peptide derived from C-terminus of human tubulin beta.
 Control Tissue    Lung, Skin
 Cellular Localization    Cytoplasm
 Entrez Gene Code    203068
 Pathway    Cytoskeletal Proteins
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 Preparation and Storage    Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
 Other Notes    Small volumes of anti-TUBB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TUBB antibody

   Microtubules, the major cytoskeletal elements found in all eukaryotic cells, consist of tubulin, which is a dimer of two 55kDa subunits: alpha and beta. Microtubules play key roles in chromosome segregation in mitosis, intracellular transport, ciliary and flagellar bending, and structural support of the cytoskeleton. This antibody does not cause the 10-nm filaments to collapse into large lateral aggregates collecting in the cell periphery or tight juxtanuclear caps. It does not block microtubule assembly. Ab-3 does not inhibit polymerization or depolymerization of platelet tubulin in vitro. It blocks (by 70-80%) the ability of tubulin dimers (with GppNHp bound) to promote a stable inhibition of adenylyl cyclase.
 Applications Tested/Suitable for anti-TUBB antibody   

Immunohistochemistry (IHC) Paraffin

 Application Notes for anti-TUBB antibody    Immunohistochemistry Procedure
Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:200. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue section in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min. Primary Antibody Incubation: Incubate for 10 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system.
Immunohistochemistry Dilution: 1:200
IHC Positive Control: Lung, Skin
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 Immunohistochemistry (IHC) of anti-TUBB antibody    Human lung stained with anti-tubulin beta antibody
anti-TUBB antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TUBB. It may not necessarily be applicable to this product.
 NCBI GI #    29788785
 NCBI GeneID    203068
 NCBI Accession #    NP_821133.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_178014.3 [Other Products]
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 UniProt Secondary Accession #    P05218; Q8WUC1; Q9CY33 [Other Products]
 UniProt Related Accession #    P07437 [Other Products]
 Molecular Weight    55 kDa [Similar Products]
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 NCBI Official Full Name    tubulin beta chain isoform b
 NCBI Official Synonym Full Names    tubulin, beta class I
 NCBI Official Symbol    TUBB [Similar Products]
 NCBI Official Synonym Symbols   
M40; TUBB1; TUBB5; CDCBM6; OK/SW-cl.56
[Similar Products]
 NCBI Protein Information    tubulin beta chain; beta Ib tubulin; tubulin beta-1 chain; tubulin beta-5 chain; tubulin, beta polypeptide
 UniProt Protein Name    Tubulin beta chain
 UniProt Synonym Protein Names   
Tubulin beta-5 chain
 Protein Family    Tubulin
 UniProt Gene Name    TUBB [Similar Products]
 UniProt Synonym Gene Names    TUBB5 [Similar Products]
 UniProt Entry Name    TBB5_HUMAN
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 NCBI Summary for TUBB    This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [provided by RefSeq, Jun 2014]
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 UniProt Comments for TUBB    TUBB: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. May interact with RNABP10. Interacts with PIFO/C1orf88. Ubiquitously expressed with highest levels in spleen, thymus and immature brain. Belongs to the tubulin family.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 6p21.33

Cellular Component: microtubule; cytoskeleton; nuclear envelope lumen; cytosol; nucleus

Molecular Function: GTPase activity; protein domain specific binding; protein binding; GTP binding; structural constituent of cytoskeleton; MHC class I protein binding; ubiquitin protein ligase binding; protein complex binding; GTPase activating protein binding; structural molecule activity

Biological Process: protein polymerization; cell division; natural killer cell mediated cytotoxicity; metabolic process; organelle organization and biogenesis; cytoskeleton-dependent intracellular transport; spindle assembly; mitotic cell cycle; cell motility; G2/M transition of mitotic cell cycle; cellular process; microtubule-based process

Disease: Cortical Dysplasia, Complex, With Other Brain Malformations 6
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 Research Articles on TUBB    1. Citrullination of TUBB is associated with neoplasms.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TUBB antibodyPathways associated with anti-TUBB antibody
 Reference Product  PubMed Publications
 UBC antibody  >2 publications with TUBB and UBC
 HSET antibody  >1 publications with TUBB and HSET
 Products by Pathway  Pathway Diagram
 Anchoring Of The Basal Body To The Plasma Membrane Pathway antibodies  Anchoring Of The Basal Body To The Plasma Membrane Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Loss Of Nlp From Mitotic Centrosomes Pathway antibodies  Loss Of Nlp From Mitotic Centrosomes Pathway Diagram
 Loss Of Proteins Required For Interphase Microtubule Organizationfrom The Centrosome Pathway antibodies  Loss Of Proteins Required For Interphase Microtubule Organizationfrom The Centrosome Pathway Diagram
Diseases associated with anti-TUBB antibodyOrgans/Tissues associated with anti-TUBB antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >9 publications with TUBB and Nervous System Diseases
 Lung Diseases Antibodies  >9 publications with TUBB and Lung Diseases
 Lung Neoplasms Antibodies  >7 publications with TUBB and Lung Neoplasms
 Brain Diseases Antibodies  >7 publications with TUBB and Brain Diseases
 Hematologic Diseases Antibodies  >6 publications with TUBB and Hematologic Diseases
 Neoplasms, Experimental Antibodies  >4 publications with TUBB and Neoplasms, Experimental
 Inflammation Antibodies  >4 publications with TUBB and Inflammation
 Carcinoma, Squamous Cell Antibodies  >4 publications with TUBB and Carcinoma, Squamous Cell
 Adenocarcinoma Antibodies  >4 publications with TUBB and Adenocarcinoma
 Ovarian Neoplasms Antibodies  >3 publications with TUBB and Ovarian Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >19 publications with TUBB and Blood
 Bone Antibodies  >11 publications with TUBB and Bone
 Brain Antibodies  >11 publications with TUBB and Brain
 Lung Antibodies  >9 publications with TUBB and Lung
 Liver Antibodies  >5 publications with TUBB and Liver
 Bone Marrow Antibodies  >5 publications with TUBB and Bone Marrow
 Vascular Antibodies  >5 publications with TUBB and Vascular
 Eye Antibodies  >4 publications with TUBB and Eye
 Heart Antibodies  >4 publications with TUBB and Heart
 Intestine Antibodies  >4 publications with TUBB and Intestine
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